Determination of gemfibrozil in pharmaceutical and urine samples by square-wave adsorptive stripping voltammetry using a glassy carbon electrode modified with multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film

Author(s)

Ardila, Jorge Armando ^[1] ; Oliveira, Geiser Gabriel ^[1] ; Medeiros, Roberta Antigo ^[1] ; Fatibello-Filho, Orlando ^{[1, 2]}

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

^[2] INCT Bioanalit, Campinas, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 690, p. 32-37, FEB 1 2013.
• Web of Science Citations: 20

Abstract

Glassy carbon electrode modified with functionalized multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film was used to develop a sensitive and simple square-wave adsorptive stripping voltammetric (SWAdSV) method for the determination of gemfibrozil. The cyclic voltammograms obtained showed one irreversible anodic peak for gemfibrozil at a potential of 1.3 V using a 0.1 mol L-1 phosphate buffer solution (pH 2.0). The cyclic voltammetric responses were studied with regard to scan rate, and the number of electrons transferred during the oxidation process was calculated. A calibration curve for gemfibrozil in the concentration range from 75 to 1000 nmol L-1 with a detection limit of 53 nmol L-1 were obtained. The proposed SWAdSV method was successfully applied to determine gemfibrozil in pharmaceutical and urine samples with good accuracy and precision. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 11/00601-9 - Application of boron-doped diamond and amorphous carbon nitride electrodes for the simultaneous determination of drugs of different therapeutic groups in pharmaceutical formulations and urine samples
• Grantee: Roberta Antigo Medeiros
• Support Opportunities: Scholarships in Brazil - Post-Doctoral