| Full text | |
| Author(s): |
Ardila, Jorge Armando
[1]
;
Oliveira, Geiser Gabriel
[1]
;
Medeiros, Roberta Antigo
[1]
;
Fatibello-Filho, Orlando
[1, 2]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
[2] INCT Bioanalit, Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 690, p. 32-37, FEB 1 2013. |
| Web of Science Citations: | 20 |
| Abstract | |
Glassy carbon electrode modified with functionalized multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film was used to develop a sensitive and simple square-wave adsorptive stripping voltammetric (SWAdSV) method for the determination of gemfibrozil. The cyclic voltammograms obtained showed one irreversible anodic peak for gemfibrozil at a potential of 1.3 V using a 0.1 mol L-1 phosphate buffer solution (pH 2.0). The cyclic voltammetric responses were studied with regard to scan rate, and the number of electrons transferred during the oxidation process was calculated. A calibration curve for gemfibrozil in the concentration range from 75 to 1000 nmol L-1 with a detection limit of 53 nmol L-1 were obtained. The proposed SWAdSV method was successfully applied to determine gemfibrozil in pharmaceutical and urine samples with good accuracy and precision. (C) 2012 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 11/00601-9 - Application of boron-doped diamond and amorphous carbon nitride electrodes for the simultaneous determination of drugs of different therapeutic groups in pharmaceutical formulations and urine samples |
| Grantee: | Roberta Antigo Medeiros |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |