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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region

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Eliane Soler Parra ; Vanessa Helena de Souza Zago ; Natália Baratella Panzoldo ; Fernanda Alexandre ; Felipe Vendrame ; Vitor Wilson de Moura Virginio ; Isabela Calanca Vieira ; Marcelo Scarpari Dutra Rodrigues ; Angela de Souza Cassol ; Fabio D'Alexandri ; Vera Sylvia Castanho ; Rui Nakamura ; Jamal Baracat ; Mirian Regina Gardin Danelon ; Ronise Carla Sass Pozeti ; Ana Cândida Coutinho Facin ; Hilda Maria da Silva Honorio ; Simone de Cássia Dias Mesquita ; Marcio Jorge da Silva ; Marielza Crosgnac Feres Lot ; Valéria Sutti Nunes ; Camila Canteiro Leança ; Edna Regina Nakandakare ; Eder Carlos Rocha Quintão ; Eliana Cotta de Faria
Total Authors: 25
Document type: Journal article
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial; v. 49, n. 1, p. 26-33, Fev. 2013.

INTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) &#8805; 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias. (AU)

FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
Grantee:Eder Carlos Rocha Quintão
Support type: Research Projects - Thematic Grants