H-2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid

Author(s)

Silva, Denise Brentan ^{[1, 2, 3]} ; Guaratini, Thais ^[1] ; Vessecchi, Ricardo ^[1] ; Lopes, Norberto Peporine ^[1] ; Cramer, Benedikt ^[3] ; Humpf, Hans-Ulrich ^[3] ; Caltegari Lopes, Joao Luis ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, BR-14030090 Ribeirao Preto, SP - Brazil

^[3] Univ Munster, Inst Lebensmittelchem, D-48149 Munster - Germany

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF MASS SPECTROMETRY; v. 19, n. 5, p. 345-350, 2013.
• Web of Science Citations: 4

Abstract

Erythrina alkaloids, which contain a spirocyclic structure, are well known due to their important biological activity at the central nervous system. In this study, systematic electrospray ionization tandem mass spectrometry (ESI-MS/MS) and ESI-multistage mass spectrometry (MSn) analysis of erythraline have shown an unexpected H-2 neutral elimination reaction. We have investigated the formation of these ions by accurate-mass ESI-MS/MS with different analyzers and the data suggest a possible unimolecular reaction of H-2 loss. (AU)

• FAPESP's process: 12/18031-7 - Application of MALDI-MS/MS in the vicenin-2 and derivatives analyses: understanding the ionization processes to production of the images
• Grantee: Denise Brentan da Silva
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system
• Grantee: Norberto Peporine Lopes
• Support type: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 11/13281-2 - Evaluation of alkaloids metabolism of Erythrina verna
• Grantee: Thais Guaratini
• Support type: Scholarships in Brazil - Post-Doctorate