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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

H-2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid

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Silva, Denise Brentan [1, 2, 3] ; Guaratini, Thais [1] ; Vessecchi, Ricardo [1] ; Lopes, Norberto Peporine [1] ; Cramer, Benedikt [3] ; Humpf, Hans-Ulrich [3] ; Caltegari Lopes, Joao Luis [1]
Total Authors: 7
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, BR-14030090 Ribeirao Preto, SP - Brazil
[3] Univ Munster, Inst Lebensmittelchem, D-48149 Munster - Germany
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF MASS SPECTROMETRY; v. 19, n. 5, p. 345-350, 2013.
Web of Science Citations: 4

Erythrina alkaloids, which contain a spirocyclic structure, are well known due to their important biological activity at the central nervous system. In this study, systematic electrospray ionization tandem mass spectrometry (ESI-MS/MS) and ESI-multistage mass spectrometry (MSn) analysis of erythraline have shown an unexpected H-2 neutral elimination reaction. We have investigated the formation of these ions by accurate-mass ESI-MS/MS with different analyzers and the data suggest a possible unimolecular reaction of H-2 loss. (AU)

FAPESP's process: 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 11/13281-2 - Evaluation of alkaloids metabolism of Erythrina verna
Grantee:Thais Guaratini
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/18031-7 - Application of MALDI-MS/MS in the vicenin-2 and derivatives analyses: Understanding the ionization processes to production of the images
Grantee:Denise Brentan da Silva
Support type: Scholarships in Brazil - Post-Doctorate