Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents

Full text
Author(s):
Netto, Barbara Dal Molin [1, 2] ; Landi Masquio, Deborah Cristina [1, 2] ; da Silveira Campos, Raquel Munhoz [1, 2] ; Sanches, Priscila de Lima [1, 2] ; Corgosinho, Flavia Campos [1, 2] ; Tock, Lian ; Oyama, Lila Missae [2] ; de Mello, Marco Tulio [1, 2, 3] ; Tufik, Sergio [1, 3] ; Damaso, Ana Raimunda [1, 2, 4, 5]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, UNIFESP EPM, Sao Paulo - Brazil
[2] UNIFESP EPM, Post Grad Program Nutr, Sao Paulo - Brazil
[3] UNIFESP EPM, Dept Psychobiol, Sao Paulo - Brazil
[4] UNIFESP EPM, Dept Biosci, Sao Paulo - Brazil
[5] UNIFESP EPM, Post Grad Program Interdisciplinary Hlth Sci, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: NUTRICION HOSPITALARIA; v. 29, n. 2, p. 305-314, FEB 2014.
Web of Science Citations: 0
Abstract

The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents. Background \& Aims: The role of diet glycemic index (GI) in the control of orexigenic and anorexigenic factors of the energy balance is still not clear. The present study aimed to assess whether the habitual diet, according to different GI foods, exerts influence on regulation of energy balance markers and the effects of interdisciplinary intervention in obese adolescents. Methods: A total of 55 obese adolescents, aged from 14 to 19 years, were submited to one year of interdisciplinary therapy and were divided in two groups, according to the predominant dietary pattern of food intake: high-GI group (H-GI; n = 29) and moderate/low-GI group (M/L-GI; n = 26). Results: The concentration of orexigenic factor AgRP (p < 0.01), visceral fat (p = 0.04) and visceral/subcutaneous ratio (p = 0.03) were higher in the group of H-GI when compared with M/L-GI group. Moreover, the habitual consumption of H-GI foods was an independent predictor to explain changes in AgRP concentrations. After one year of interdisciplinary therapy, the adolescents presented significant reductions in body weight, total body fat (%), visceral and subcutaneous fat and HOMA-IR, as well as a significant increase of fat free mass (%). Conclusions: Our results may suggest that habitual H-GI diet could upregulate orexigenic pathways, contributing to vicious cycle between undesirable diets, deregulates energy balance and predispose to obesity. One the other hand, one year of interdisciplinary therapy can significant improves metabolic profile and central obesity in adolescents. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants
FAPESP's process: 13/04136-4 - Analysis of neuroendocrine regulation of balance energy and inflammatory factors in obese adults submitted to bariatric surgery
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants