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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A two-step synthesis of the bioprotective agent JP4-039 from N-Boc-L-leucinal

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Author(s):
Bernardim, Barbara [1] ; Burtoloso, Antonio C. B. [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Tetrahedron; v. 70, n. 20, p. 3291-3296, MAY 20 2014.
Web of Science Citations: 6
Abstract

An expedited synthesis of the bioprotective agent JP4-039 is described from N-Boc-L-leucinal in 50% overall yield. The synthesis involves the use of an alpha,beta-unsaturated diazoketone as the key intermediate, followed by a photochemical Wolff rearrangement in the presence of 4-amino-TEMPO (4-AT). (C) 2013 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/22274-2 - Study in the photochemical Wolff rearrangement from a,b-unsaturated diazoketones. Aplication in diversity synthesis of nitrogen and oxygen heterocycles
Grantee:Barbara Bernardim de Souza
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/54040-8 - Acquisition of a high-resolution Orbitrap mass spectrometer for the discovery and structural analysis of biologically active compounds: applications in proteomics, biomarkers, synthesis, isolation, and characterization of natural products, studies of redox systems in food and enzymatic synthesis
Grantee:Emanuel Carrilho
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 12/04685-5 - New synthetic methodologies for the construction of pyrrolidine, piperidine and indolizidine systems
Grantee:Antonio Carlos Bender Burtoloso
Support Opportunities: Regular Research Grants