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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids

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Callejon, Daniel R. [1, 2] ; Riul, Thalita B. [3] ; Feitosa, Luis G. P. [1, 2] ; Guaratini, Thais [1] ; Silva, Denise B. [1] ; Adhikari, Achyut [1, 4] ; Shrestha, Ram L. (S) [5] ; Marques, Lucas M. M. [1] ; Baruffi, Marcelo D. [3] ; Lopes, Joao L. C. [1] ; Lopes, Norberto P. [1]
Total Authors: 11
[1] Univ Sao Paulo, FCFRP, NPPNS, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, BR-14030090 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, FCFRP, Dept Anal Clin, BR-14040903 Ribeirao Preto, SP - Brazil
[4] Univ Karachi, ICCBS, HEJ Res Inst Chem, Karachi 75270 - Pakistan
[5] Tribhuvan Univ, Kathmandu - Nepal
Total Affiliations: 5
Document type: Journal article
Source: Molecules; v. 19, n. 5, p. 5692-5703, MAY 2014.
Web of Science Citations: 16

Leishmaniasis is one of the World's most problematic diseases in developing countries. Traditional medicines to treat leishmaniasis have serious side effects, as well as significant parasite resistance problems. In this work, two alkaloids 1 and 2 were obtained from Corydalis govaniana Wall and seven alkaloids 3-9, were obtained from Erythrina verna. The structures of the compounds were confirmed by mass spectrometry and 1D- and 2D-NMR spectroscopy. The leishmanicidal activity of compounds 1-9 against Leishmania amazonensis was tested on promastigote forms and cytotoxicity against J774 (macrophage cell line) was assessed in vitro. Compound 1 showed potent activity (IC50 = 0.18 mu g/mL), compared with the standard amphotericin B (IC50 = 0.20 mu g/mL). The spirocyclic erythrina-alkaloids showed lower leishmanicidal activity than dibenzoquinolizine type alkaloids. (AU)

FAPESP's process: 09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 11/13281-2 - Evaluation of alkaloids metabolism of Erythrina verna
Grantee:Thais Guaratini
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/18031-7 - Application of MALDI-MS/MS in the vicenin-2 and derivatives analyses: Understanding the ionization processes to production of the images
Grantee:Denise Brentan da Silva
Support type: Scholarships in Brazil - Post-Doctorate