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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuropsychological dysfunction related to earlier occupational exposure to mercury vapor

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Author(s):
E.C. Zachi [1] ; D.F. Ventura [2] ; M.A.M. Faria [3] ; A. Taub [4]
Total Authors: 4
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina. Instituto de Psicologia e Núcleo de Neurociências e Comportamento
[2] Universidade de São Paulo. Faculdade de Medicina. Instituto de Psicologia e Núcleo de Neurociências e Comportamento
[3] Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Legal, Ética Médica e Medicina Social e do Trabalho
[4] Universidade de São Paulo. Faculdade de Medicina. Departamento de Psiquiatria - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 40, n. 3, p. 425-433, 2007-03-00.
Abstract

We assessed the neuropsychological test performances of 26 patients (mean age = 41.5 ± 6.1 years; mean years of education = 9.8 ± 1.8; 20 males) diagnosed with chronic occupational mercurialism who were former workers at a fluorescent lamp factory. They had been exposed to elemental mercury for an average of 10.2 ± 3.8 years and had been away from this work for 6 ± 4.7 years. Mean urinary mercury concentrations 1 year after cessation of work were 1.8 ± 0.9 µg/g creatinine. Twenty control subjects matched for age, gender, and education (18 males) were used for comparison. Neuropsychological assessment included attention, inhibitory control, verbal and visual memory, verbal fluency, manual dexterity, visual-spatial function, executive function, and semantic knowledge tests. The Beck Depression Inventory and the State and Trait Inventory were used to assess depression and anxiety symptoms, respectively. The raw score for the group exposed to mercury indicated slower information processing speed, inferior performance in psychomotor speed, verbal spontaneous recall memory, and manual dexterity of the dominant hand and non-dominant hand (P < 0.05). In addition, the patients showed increased depression and anxiety symptoms (P < 0.001). A statistically significant correlation (Pearson) was demonstrable between mean urinary mercury and anxiety trait (r = 0.75, P = 0.03). The neuropsychological performances of the former workers suggest that occupational exposure to elemental mercury has long-term effects on information processing and psychomotor function, with increased depression and anxiety also possibly reflecting the psychosocial context. (AU)

FAPESP's process: 02/12733-8 - Sensory losses caused by mercury intoxication: psychophysical and neurophysiological studies in patients and in animal models
Grantee:Dora Selma Fix Ventura
Support Opportunities: Research Projects - Thematic Grants