Functional changes of human quadriceps muscle injured by eccentric exercise

Author(s)

F.V. Serrão ^[1] ; B. Foerster ^[2] ; S. Spada ^[3] ; M.M.B. Morales ^[4] ; V. Monteiro-Pedro ^[5] ; A. Tannús ^[6] ; T.F. Salvini ^[7]

Affiliation

^[1] Universidade Federal de São Carlos. Unidade de Plasticidade Muscular. Departamento de Fisioterapia - Brasil

^[2] Universidade de São Paulo. Instituto de Física de São Carlos. Grupo de Ressonância Magnética - Brasil

^[3] Universidade Federal de São Carlos. Unidade de Plasticidade Muscular. Departamento de Fisioterapia - Brasil

^[4] Universidade Federal de São Carlos. Unidade de Plasticidade Muscular. Departamento de Fisioterapia - Brasil

^[5] Universidade Federal de São Carlos. Unidade de Plasticidade Muscular. Departamento de Fisioterapia - Brasil

^[6] Universidade de São Paulo. Instituto de Física de São Carlos. Grupo de Ressonância Magnética - Brasil

^[7] Universidade Federal de São Carlos. Unidade de Plasticidade Muscular. Departamento de Fisioterapia - Brasil

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 36, n. 6, p. 781-786, 2003-06-00.

Abstract

The present study evaluated functional changes of quadriceps muscle after injury induced by eccentric exercise. Maximal isometric torque of quadriceps and the surface electromyography (root mean square, RMS, and median frequency, MDF) of the vastus medialis oblique (VMO) and vastus lateralis (VL) muscles were examined before, immediately after and during the first 7 days after injury. Serum creatine kinase (CK) levels and magnetic resonance imaging (MRI) were used to identify muscle injury. The subject was used as her own control and percent refers to pre-injury data. Experiments were carried out with a sedentary 23-year-old female. Injury was induced by 4 bouts of 15 maximal isokinetic eccentric contractions (angular velocity of 5º/s; range of motion from 40º to 110º of knee flexion). The isometric torque of the quadriceps (knee at 90º flexion) decreased 52% immediately after eccentric exercise and recovered on the 5th day. The highest reduction of RMS occurred on the 2nd day after injury in both VL (63%) and VMO (66%) and only VL recovered to the pre-injury level on the 7th day. Immediately after injury, the MDF decreased by 5 and 3% (VMO and VL, respectively) and recovered one day later. Serum CK levels increased by 109% on the 2nd day and were still increased by 32% on the 7th day. MRI showed large areas of injury especially in the deep region of quadriceps. In conclusion, eccentric exercise decreased the isometric torque and electromyographic signals of quadriceps muscle, which were recovered in one week, despite the muscle regeneration signals. (AU)