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Discovery and development of novel repellents against Aedes aegypti

Grant number: 17/08688-2
Support type:Research Grants - Innovative Research in Small Business - PIPE
Duration: June 01, 2018 - May 31, 2019
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal researcher:Edson Katekawa
Grantee:Edson Katekawa
Company:Chemyunion Ltda
CNAE: Pesquisa e desenvolvimento experimental em ciências físicas e naturais
City: Sorocaba
Assoc. researchers: Bianca da Silva Sufi

Abstract

According to the World Health Organization, vector borne diseases are responsible for over 17% of all infectious diseases and cause over 1 million deaths worldwide each year. Aedes aegypti is one of the most prevalent vectors; it may infect over 2.5 billion humans in over 100 countries. In Brazil, up to the 2016 Epidemiologic Week 49, almost 1% of the Brazilian population had zika, dengue or chikungunya fever, and 774 deaths were recorded.From the personal protection view by use of repellents, Anvisa recommends three chemical substances: DEET, IR3535 and icaridin, besides citronella oil. However, several studies indicate that insects may develop some kind of behavioral adaptation or resistance when exposed to chemical agents. Hence, new repellent development for populational protection against insects has a fundamental role in the public health management.The objective of this project is to discover and develop new substances for use as insect repellent, especially against Aedes aegypti, using molecular modelling and computational simulation methods associated to in vitro efficacy testing. (AU)

Articles published in Pesquisa para Inovação FAPESP about research grant:
Empresas paulistas e mexicanas trocam informações sobre tecnologias de combate a arboviroses 
Entrepreneurs from São Paulo and Mexico exchange information on technology to combat arboviral diseases