Advanced search
Start date
Betweenand

Photophysical characterization and anti-inflammatory potential of betalains

Grant number: 19/06391-8
Support Opportunities:Regular Research Grants
Start date: July 01, 2019
End date: June 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Erick Leite Bastos
Grantee:Erick Leite Bastos
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant(s):19/08450-1 - Natural photoredox and photobioredox mediators, AP.R SPRINT

Abstract

Betalains are chromoalkaloids found in plants and fungi that have been used as drugs, redox mediators, antioxidants and safe dyes. In this research project, we propose to: i) optimize the biotechnological production of betalamic acid, the biosynthetic precursor of betalains, ii) produce betalains anti-inflammatories that act at the level of NF-ºB and COX-1/COX-2, iii) develop betalamic rotaxanes that self-assemble in aqueous media, iv) include data on natural betalains in the PhotochemCAD database by invitation of its development group, and v) understand the behavior of electronically excited betalains by employing ultra-fast spectroscopy. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAKASHIMA, KARINA K.; BASTOS, ERICK L.. Rationale on the High Radical Scavenging Capacity of Betalains. ANTIOXIDANTS, v. 8, n. 7, . (13/24964-9, 14/22136-4, 16/21445-9, 19/06391-8)
FERNANDES, ARTHUR B.; PAVLIUK, V, MARIIA; PAUN, CRISTINA; CARVALHO, ALEXANDRINA C.; NOMURA, CASSIANA S.; LEWIN, ERIK; LINDBLAD, REBECKA; CAMARGO, PEDRO H. C.; SA, JACINTO; BASTOS, ERICK L.. Recoverable and Reusable Polymer Microbead-Supported Metal Nanocatalysts for Redox Chemical Transformations. ACS APPLIED NANO MATERIALS, v. 3, n. 2, p. 1722-1730, . (14/22136-4, 17/10346-2, 19/08450-1, 19/06391-8, 15/25629-4)
PIOLI, RENAN MORAES; MATTIOLI, RENAN RODINI; ESTEVES, LARISSA CERRATO; DOCHEV, STEFAN; BASTOS, ERICK LEITE. Comparison of the effect of N-methyl and N-aryl groups on the hydrolytic stability and electronic properties of betalain dyes. DYES AND PIGMENTS, v. 183, p. 7-pg., . (14/22136-4, 16/21445-9, 17/20133-6, 19/06391-8)
PENNA, TATIANA C.; CERVI, GUSTAVO; RODRIGUES-OLIVEIRA, ANDRE F.; YAMADA, BRUNO D.; LIMA, RAFAEL Z. C.; MENEGON, JAIR J.; BASTOS, ERICK L.; CORRERA, THIAGO C.. Development of a photoinduced fragmentation ion trap for infrared multiple photon dissociation spectroscopy. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, . (14/15962-5, 15/08539-1, 16/19698-6, 19/06391-8, 17/20262-0, 18/20592-3)
FREITAS-DORR, B. C.; MACHADO, C. O.; PINHEIRO, A. C.; FERNANDES, A. B.; DORR, F. A.; PINTO, E.; LOPES-FERREIRA, M.; ABDELLAH, M.; SA, J.; RUSSO, L. C.; et al. A metal-free blue chromophore derived from plant pigments. SCIENCE ADVANCES, v. 6, n. 14, . (18/25842-8, 14/10563-5, 16/21445-9, 15/25629-4, 14/22136-4, 19/06391-8, 15/24760-0, 15/18474-4)
DA SILVA, SANDRA M.; LANG, ANDRE P.; DOS SANTOS, ANA PAULA F.; CABELLO, MAIDILEYVIS C.; CISCATO, LUIZ FRANCISCO M. L.; BARTOLONI, FERNANDO H.; BASTOS, ERICK L.; BAADER, WILHELM J.. Cyclic Peroxidic Carbon Dioxide Dimer Fuels Peroxyoxalate Chemiluminescence. Journal of Organic Chemistry, v. 86, n. 17, p. 11434-11441, . (19/06391-8, 14/22136-4)
PINHEIRO, AMANDA CAPISTRANO; FAZZI, RODRIGO BONI; ESTEVES, LARISSA CERRATO; MACHADO, CAROLINE OLIVEIRA; DORR, FELIPE AUGUSTO; PINTO, ERNANI; HATTORI, YOCEFU; SA, JACINTO; FERREIRA, ANA MARIA DA COSTA; BASTOS, ERICK LEITE. A bioinspired nitrone precursor to a stabilized nitroxide radical. Free Radical Biology and Medicine, v. 168, p. 110-116, . (19/06391-8, 15/18474-4, 19/15412-9, 13/07937-8, 14/22136-4)
SOARES, DOUGLAS M. M.; GONCALVES, LETICIA C. P.; MACHADO, CAROLINE O.; ESTEVES, LARISSA C.; STEVANI, CASSIUS, V; OLIVEIRA, CARLA C.; DORR, FELIPE A.; PINTO, ERNANI; ADACHI, FLAVIA M. M.; HOTTA, CARLOS T.; et al. Reannotation of Fly Amanita L-DOPA Dioxygenase Gene Enables Its Cloning and Heterologous Expression. ACS OMEGA, v. 7, n. 18, p. 10-pg., . (19/12605-0, 19/15412-9, 17/22501-2, 18/25842-8, 15/24760-0, 13/07914-8, 19/06391-8)
PENNA, TATIANA C.; CERVI, GUSTAVO; RODRIGUES-OLIVEIRA, ANDRE F.; YAMADA, BRUNO D.; LIMA, RAFAEL Z. C.; MENEGON, JAIR J.; BASTOS, ERICK L.; CORRERA, THIAGO C.. Development of a photoinduced fragmentation ion trap for infrared multiple photon dissociation spectroscopy. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, p. 12-pg., . (18/20592-3, 17/20262-0, 16/19698-6, 19/06391-8, 15/08539-1, 14/15962-5)