Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020

• Grant number: 20/04836-0
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2020
• End date: March 31, 2023
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: Maurício Lacerda Nogueira
• Grantee: Maurício Lacerda Nogueira
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). São José do Rio Preto , SP, Brazil
• City of the host institution: São José do Rio Preto
• Associated researchers: Carolina Colombelli Pacca ; Cássia Fernanda Estofolete
• Associated research grant: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018, AP.TEM
• Associated scholarship(s): 20/07419-0 - Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in SJ Rio Preto, SP, Brazil in 2020, BP.PD

Abstract

In a global context COVID-19 is the biggest health threat in the present days, because, in just over four months, the SARS-CoV-2 has spread to 171 countries reaching a pandemic status. Most patients with COVID-19 have a mild course of the disease, however, approximately 20% develop severe disease with a high mortality rate that is associated with age, comorbidities, and immunosuppression. Epidemiological studies are used to reveal the extent of viral spread in homes, communities, and hospitals. Thus, preventive and control measures can be established by the authorities. This project proposes to use a pre-established population cohort containing four years of data collection on the participants. The cohort is carried out in a restricted neighborhood in the municipality of São José do Rio Preto, located in the northwest region of the state of São Paulo. To this end, active participants in this study will be monitored for the appearance of symptoms related to COVID-19. A quick-access telephone number to the team will be made available in case of acute symptoms and, if necessary, referral to the local health service. Monitoring of hospitalized patients at the Hospital de Base of the Faculty of Medicine of São José do Rio Preto (FAMERP), who are suspected or confirmed by COVID-19, will also be carried out. Samples will be collected for further analysis of pro-inflammatory cytokines, possible biological markers that indicate worsening of the disease. (AU)

Scientific publications

(18)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

CAMPOS, GUILHERME R. F.; ALMEIDA, NATHALIE BONATTI FRANCO; FILGUEIRAS, PRISCILLA SOARES; CORSINI, CAMILA AMORMINO; GOMES, SARAH VIEIRA CONTIN; DE MIRANDA, DANIEL ALVIM PENA; DE ASSIS, JESSICA VIEIRA; SILVA, THAIS BARBARA DE SOUZA; ALVES, PEDRO AUGUSTO; FERNANDES, GABRIEL DA ROCHA; et al. Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant. COMMUNICATIONS MEDICINE, v. 2, n. 1, p. 4-pg., 2022-07-22. (20/07419-0, 20/04836-0)

COSTA, GUILHERME M. J.; LACERDA, SAMYRA M. S. N.; FIGUEIREDO, ANDRE F. A.; WNUK, NATALIA T.; BRENER, MARCOS R. G.; ANDRADE, LIDIA M.; CAMPOLINA-SILVA, GABRIEL H.; KAUFFMANN-ZEH, ANDREA; PACIFICO, LUCILA G. G.; VERSIANI, ALICE F.; et al. High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients. BMC Biology, v. 21, n. 1, p. 24-pg., 2023-02-16. (20/07419-0, 18/17647-0, 20/04836-0, 19/07250-9)

LUSCHER-DIAS, THOMAZ; CONCEICAO, IZABELA MAMEDE; SCHUCH, VIVIANE; MARACAJA-COUTINHO, VINICIUS; AMARAL, PAULO P.; NAKAYA, HELDER I.; HON, CC. Long non-coding RNAs associated with infection and vaccine-induced immunity. NON-CODING GENOME, v. 65, n. 4, p. 13-pg., 2021-01-01. (18/14933-2, 13/08216-2, 20/04836-0, 17/27131-9, 18/21934-5)

BANHO, CECILIA ARTICO; MARQUES, BEATRIZ DE CARVALHO; SACCHETTO, LIVIA; LIMA, ANA KAROLINE SEPEDRO; PARRA, MAISA CARLA PEREIRA; LIMA, ALEX RANIERI JERONIMO; RIBEIRO, GABRIELA; MARTINS, ANTONIO JORGE; BARROS, CLAUDIA RENATA DOS SANTOS; ELIAS, MARIA CAROLINA; et al. Dynamic clade transitions and the influence of vaccination on the spatiotemporal circulation of SARS-CoV-2 variants. NPJ VACCINES, v. 9, n. 1, p. 12-pg., 2024-08-10. (22/03645-1, 20/10127-1, 21/11944-6, 23/14670-0, 20/04836-0)

CUNHA FILHO, ANTONIO AUGUSTO DE ANDRADE; NETO, PERSEU MATHEUS PUGLIESE; PEREIRA, GABRIELA HAMRA; DE LIMA FILHO, NEUDER GOUVEIA; SAKAKISBARA, LUIS ANTONIO; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA; DE MATTOS, LUIZ CARLOS; BRANDAO, CINARA CASSIA. Portable color retinography findings in COVID-19 patients admitted to the ward. Photodiagnosis and Photodynamic Therapy, v. 45, p. 5-pg., 2024-01-16. (20/04836-0)

ESTOFOLETE, CASSIA FERNANDA; FARES, GISLAINE FUSCO; BANHO, CECILIA ARTICO; SACCHETTO, LIVIA; CAMPOS, GUILHERME R. F.; QUEIROZ, FLAVIA; MENDES, LINA DE MOURA; MACHADO SALOMAO, MARIA LUCIA; NEGRI, ANDREIA FRANCESLI; BARCELOS, MICHELA DIAS; et al. Predictors of death in COVID-19 vaccine breakthrough infections in Brazil. Journal of Infection, v. 84, n. 4, p. 3-pg., 2022-04-08. (13/21719-3, 19/06572-2, 20/04836-0)

GIOVANETTI, MARTA; SLAVOV, SVETOSLAV NANEV; FONSECA, VAGNER; WILKINSON, EDUAN; TEGALLY, HOURIIYAH; LEISTER PATANE, JOSE SALVATORE; VIALA, VINCENT LOUIS; SAN, EMMANUEL JAMES; RODRIGUES, EVANDRA STRAZZA; SANTOS, ELAINE VIEIRA; et al. Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil. NATURE MICROBIOLOGY, v. 7, n. 9, p. 14-pg., 2022-08-18. (13/08135-2, 20/10127-1, 20/04836-0, 20/05367-3)

FILHO, ANTONIO AUGUSTO DE ANDRADE CUNHA; PUGLIESE NETO, PERSEU MATHEUS; PEREIRA, GABRIELA HAMRA; FILHO, NEUDER GOUVEIA DE LIMA; SAKAKISBARA, LUIS ANTONIO; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA; DE MATTOS, LUIZ CARLOS; BRANDAO, CINARA CASSIA. Portable color retinography findings in COVID-19 patients admitted to the ward (vol 45, 103965, 2024). Photodiagnosis and Photodynamic Therapy, v. 49, p. 1-pg., 2024-10-17. (20/06471-9, 20/04836-0)

BANHO, CECILIA ARTICO; SACCHETTO, LIVIA; FERNANDES CAMPOS, GUILHERME RODRIGUES; BITTAR, CINTIA; POSSEBON, FABIO SOSSAI; ULLMANN, LEILA SABRINA; MARQUES, BEATRIZ DE CARVALHO; DUTRA DA SILVA, GISLAINE CESLESTINO; MORAES, MARILIA MAZZI; PEREIRA PARRA, MAISA CARLA; et al. Impact of SARS-CoV-2 Gamma lineage introduction and COVID-19 vaccination on the epidemiological landscape of a Brazilian city. COMMUNICATIONS MEDICINE, v. 2, n. 1, p. 11-pg., 2022-07-22. (20/07419-0, 20/04836-0)

LIMA, ANA KAROLINE SEPEDRO; BANHO, CECILIA ARTICO; SACCHETTO, LIVIA; MARQUES, BEATRIZ DE CARVALHO; DOS SANTOS, MARIANA GUEDES; RIBEIRO, MILENE ROCHA; GANDOLFI, FLORA A.; SAKOMURA, TATIANA PISSOLATI; ESTOFOLETE, CASSIA FERNANDA; NOGUEIRA, MAURICIO LACERDA. Seasonal respiratory virus trends in pediatric patients during the COVID-19 pandemic in Brazil. Brazilian Journal of Microbiology, v. N/A, p. 8-pg., 2023-08-17. (20/04836-0)

JIMENEZ, LEANDRO; CODO, ANA CAMPOS; SAMPAIO, VANDERSON DE SOUZA; OLIVEIRA, ANTONIO E. R.; KOBO FERREIRA, LUCAS KAORU; DAVANZO, GUSTAVO GASTAO; MONTEIRO, LAUAR DE BRITO; VIRGILIO-DA-SILVA, JOAO VICTOR; SILVA BORBA, MAYLA GABRIELA; DE SOUZA, GABRIELA FABIANO; et al. Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19. FRONTIERS IN MEDICINE, v. 8, AUG 20 2021. (18/14933-2, 20/04836-0)

BITTAR, CINTIA; POSSEBON, FABIO SOSSAI; ULLMANN, LEILA SABRINA; GERALDINI, DAYLA BOTT; DA COSTA, VIVALDO G.; DE ALMEIDA, LUIZ G. P.; SANCHES, PAULO RICARDO DA S.; NASCIMENTO-JUNIOR, NAILTON M.; CILLI, EDUARDO M.; BANHO, CECILIA ARTICO; et al. The Emergence of the New P.4 Lineage of SARS-CoV-2 With Spike L452R Mutation in Brazil. FRONTIERS IN PUBLIC HEALTH, v. 9, OCT 1 2021. (20/07419-0, 20/04836-0)

CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, SEP 4 2020. (20/04558-0, 16/00194-8, 19/21301-5, 18/14389-0, 18/14933-2, 17/13981-0, 20/04836-0, 18/25468-9, 16/18445-7, 18/09383-3, 18/17176-8, 19/12000-1, 19/07544-2, 19/24251-9)

ESTOFOLETE, CASSIA F.; MACHADO, LUANA F.; ZINI, NATHALIA; LUCKEMEYER, GRAZIELA D.; MORAES, MARILIA M.; DOS SANTOS, THAYSA M. I. L.; DOS SANTOS, BARBARA F.; RUIZ, LEONARDO G. P.; VASILAKIS, NIKOS; LOBO, SUZANA M. A.; et al. Presentation of fatal stroke due to SARS-CoV-2 and dengue virus coinfection. Journal of Medical Virology, v. 93, n. 3, p. 1770-1775, MAR 2021. (20/04836-0)

SACCHETTO, LIVIA; CHAVES, BARBARA APARECIDA; COSTA, EDSON RODRIGUES; DE MENEZES MEDEIROS, ALINE SOUZA; GORDO, MARCELO; ARAUJO, DANIELLE BASTOS; OLIVEIRA, DANIELLE BRUNA LEAL; DA SILVA, ANA PAULA BETARESSI; NEGRI, ANDREIA FRANCESLI; DURIGON, EDISON LUIZ; et al. Lack of Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spillover in Free-Living Neotropical Non-Human Primates, Brazil. Viruses-Basel, v. 13, n. 10, OCT 2021. (20/04836-0)

ESTOFOLETE, CASSIA F.; BANHO, CECILIA A.; CAMPOS, GUILHERME R. F.; MARQUES, BEATRIZ DE C.; SACCHETTO, LIVIA; ULLMANN, LEILA S.; POSSEBON, FABIO S.; MACHADO, LUANA F.; SYRIO, JULIANA D.; ARAUJO JUNIOR, JOAO P.; et al. Case Study of Two Post Vaccination SARS-CoV-2 Infections with P1 Variants in CoronaVac Vaccinees in Brazil. Viruses-Basel, v. 13, n. 7, JUL 2021. (20/04836-0)

AYO, CHRISTIANE MARIA; MAGALHAES, HENRIQUE; MIOLA, MARCOS PAULO; BRANDAO, CINARA CASSIA; NOGUEIRA, MAURICIO LACERDA; ESTOFOLETE, CASSIA FERNANDA; DE SOUZA, VICTOR HUGO; VISENTAINER, JEANE ELIETE LAGUILA; DE MATTOS, LUIZ CARLOS. Asymptomatic SARS-CoV-2 Infection: Association Involving the HLA-B*15 Allele Group in Brazilian Individuals. HLA, v. 105, n. 6, p. 7-pg., 2025-06-01. (20/06471-9, 20/04836-0)

SANTOS, THAYZA M. I. L.; VERSIANI, ALICE F.; CAMPOS, GUILHERME R. F.; MORAES, MARILIA M.; PARRA, MAISA C. P.; MISTRAO, NATALIA F. B.; NEGRI, ANDREIA F.; BAGNO, FLAVIA F.; GALVES, MARINA G.; MORENO, CAMILA M.; et al. Dengue and SARS-CoV-2 co-circulation and overlapping infections in hospitalized patients. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 14, p. 18-pg., 2024-11-08. (22/03645-1, 17/21452-8, 20/04836-0, 22/09229-0)