Development of new therapeutic strategies for treatment of cardiovascular diseases

• Grant number: 19/24154-3
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2020
• End date: August 31, 2024
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: CONFAP - National Council of State Research Support Foundations
• Principal Investigator: Eduardo Colombari
• Grantee: Eduardo Colombari
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: Adriana Souza Torsoni ; Aline Priscila Pansani ; Carlos Henrique Xavier Custodio ; Daniel Alves Rosa ; Débora Simões de Almeida Colombari ; Diego Basile Colugnati ; Elizabeth Pereira Mendes ; Fernanda Cristina Alcantara dos Santos ; Gustavo Rodrigues Pedrino ; James Oluwagbamigbe Fajemiroye ; Manoel Francisco Biancardi ; Marcio Alberto Torsoni ; Paulo Ricardo Lopes ; Pedro Lourenço Katayama ; Ricardo Menegatti ; Rodrigo Mello Gomes
• Associated research grant(s): 22/00555-1 - Investigation into the mechanisms of neurogenic hypertension induced by peripheral and central inflammation, AP.R SPRINT

Abstract

Cardiovascular diseases (CVDs) present the highest mortality rate in the world and hypertension is one of the main risk factors. Even considering the existing pharmacological strategies, one can still observe the high prevalence of CVDs. The renin-angiotensin system is an important regulator of cardiovascular functions and is involved in the development of several diseases related to this system. The beneficial actions of the Ang-(1-7) are well established. Additionally, it was previously observed that the fragment of this peptide, the Asp1-Arg2 dipeptide, also presented beneficial effects on the cardiovascular system. Thus, it can be considered as a therapeutic target for the treatment of CVDs. Due to limitations in the therapeutic use of peptides, strategies aiming at the development of stable compounds with similar effects of peptides with protective activities are of great relevance. Thus, the objective of this project will be to develop compounds from the Asp1-Arg2 dipeptide through encapsulation, hybridization and molecular simplification strategies that have therapeutic potential for cardiovascular diseases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KATAYAMA, PEDRO L.; LEIRAO, ISABELA P.; KANASHIRO, ALEXANDRE; MENANI, JOSE, V; ZOCCAL, DANIEL B.; COLOMBARI, DEBORA S. A.; COLOMBARI, EDUARDO. The carotid body: A novel key player in neuroimmune interactions. FRONTIERS IN IMMUNOLOGY, v. 13, p. 10-pg., 2022-10-24. (19/11196-0, 19/24154-3, 15/23467-7)