National Center for Research and Innovation in Mental Health (CISM)

• Grant number: 21/12901-9
• Support Opportunities: Research Grants - Research Centers in Engineering Program
• Start date: November 01, 2022
• End date: October 31, 2027
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Eurípedes Constantino Miguel Filho
• Grantee: Eurípedes Constantino Miguel Filho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais:( Atuais ): Guilherme Vanoni Polanczyk ; Jair de Jesus Mari ; Lislaine Aparecida Fracolli ; Nuno Jorge Carvalho de Sousa ; Paulo Rossi Menezes
• Pesquisadores principais:( Anteriores ): Orestes Vicente Forlenza
• Associated researchers: Alfredo Almeida Pina de Oliveira ; Altair Massaro ; André de Queiroz Constantino Miguel ; Andre Russowsky Brunoni ; Arthur Caye ; Ary Gadelha de Alencar Araripe Neto ; Carolina Cappi ; Celene Aparecida Ferrari Audi ; Daniel Graça Fatori de Sá ; Danielle Soares Teixeira ; Douglas Teixeira Leffa ; Elizabeth Shephard ; Giovanni Abrahão Salum Júnior ; Guilherme Vanoni Polanczyk ; Heloísa Garcia Claro Fernandes ; Ives Cavalcante Passos ; João Ricardo Sato ; Luciana Mori Gomes ; Luis Augusto Paim Rohde ; Luísa Shiguemi Sugaya ; Luiz Roberto Bumbles de Abreu Carvalho ; Luiza Kvitko Axelrud ; Marcelo Camargo Batistuzzo ; Marcelo Jose Abduch Adas Branas ; Marcelo Queiroz Hoexter ; Marco Antonio Bego ; Marcos Leite Santoro ; Marcos Signoretti Croci ; Maria Conceição do Rosário ; Mauricio Scopel Hoffmann ; Milton de Arruda Martins ; Natalia Becker ; Patricia Pinheiro Bado ; Patricia Zen Tempski ; Paulo Rossi Menezes ; Pedro Mario Pan Neto ; Renatha El Rafihi Ferreira ; Rodolfo Furlan Damiano ; Rodrigo Affonseca Bressan ; Roseli Gedanke Shavitt ; Síntia Iole Nogueira Belangero ; Valéria Vernaschi Lima ; Vanessa Kiyomi Ota Kuniyoshi
• Associated research grant(s): 24/14145-5 - Multi-user equipment approved in grant 2021/12901-9: functional Near-Infrared Spectroscopy (fNIRS), AP.EMU; 24/02150-4 - Parent-child trio sequencing study of early-onset Schizophrenia, AP.R; 24/02157-9 - Irritability and family environment in a multigenerational cohort: Brazilian High Risk Cohort Study (BHRCS), AP.R
• Associated scholarship(s): 25/11977-2 - Prediction of suicidal ideation through a facial expression reading algorithm in patients with depression, BP.IC; 24/22680-8 - Establishment, standardization and optimization of molecular laboratory processes of the Brazilian High-Risk Cohort for Mental Disorders, BP.TT; 25/05925-0 - Innovation and Implementation of Technologies for Mental Health Promotion in Public Services of Brazilian Municipalities, BP.PD; + associated scholarships 25/00485-1 - Support for Scientific Research and Communication in Mental Health, BP.TT; 25/06212-7 - Study on the implementation of an interactive technological intervention to improve mental health symptoms in Primary Health Care users (CONEMO Project), BP.PD; 25/02275-4 - PERFORMANCE EVALUATION OF AN ALGORITHM BASED ON INTERPRETATION OF FACIAL EXPRESSIONS (EGO2SAVE) IN IDENTIFYING DEPRESSIVE SYMPTOMS, BP.IC; 25/02251-8 - The combination of NEUROFEEDBACK by HEMOENCEPHALOGRAPHIC (HEG) and MINDFULNESS for the reduction of stress in the workplace: Randomized Clinical Trial., BP.IC; 24/23866-8 - Implementation of a Nursing Home Visit Program in the Municipality of Indaiatuba., BP.IC; 24/23867-4 - Implementation of a Nursing Home Visit Program in the Municipality of Jaguariúna., BP.IC; 24/23883-0 - Implementation of a nursing home visit program in the city of Indaiatuba., BP.IC; 25/01897-1 - Extension project in Scientific Dissemination for the National Center for Research and Innovation in Mental Health (CISM), BP.IC; 24/00918-2 - Pilot study of the viability of a technological intervention for anxiety symptoms in Primary Health Care users., BP.IC; 24/17240-9 - Comparative analysis of the academic performance of university students with and without symptoms of Attention Deficit Hyperactivity Disorder, BP.IC; 24/18430-6 - Adolescent pregnancy, experience and possibilities for intervention: a qualitative evaluation of the Primeiros Laços program, BP.DD; 24/17622-9 - Implementation of the First Ties Program: A Qualitative Approach, BP.DD; 24/15964-0 - TRAINING PSYCHOLOGISTS TO USE INTERNET-BASED PSYCHOTHERAPY IN PRIMARY CARE: AN IMPLEMENTATION STUDY IN THE MUNICIPALITIES OF INDAIATUBA AND JAGUARIÚNA, BP.DD; 24/16607-6 - Pilot study of CONEMO implementation in cases of depression and the difference in outcomes according to social vulnerability., BP.IC; 24/15826-6 - MENTAL HEALTH LITERACY FOR EDUCATORS: TUTORING PROJECT FOR DISTANCE EDUCATION ON ANXIETY DISORDERS AND SUBSTANCE USE PREVENTION, BP.IC; 24/15683-0 - Development of monitoring strategies in an academic research center, BP.TT; 24/13693-9 - Characterization of hazing and its association with mental health in Brazilian university students, BP.IC; 24/09085-3 - Development of an interactive technological intervention to improve mental health symptoms in users of Primary Health Care and analysis of its effectiveness through a community clinical trial., BP.TT; 24/10266-2 - Implementation and validation study of the S-RAP digital tool in Primary Health Care, BP.DD; 24/07304-0 - Investigation of the effects of mental disorders in the family on children and adolescents, BP.IC; 24/10058-0 - Ketamine Versus Crisis Response Plan Versus Enhanced Treatment as Usual for Suicide: A Pragmatic Controlled Trial in Two Brazilian Cities, BP.PD; 24/07370-2 - Prevalence of common mental disorders in primary health care of the city of Indaituba - SP, BP.IC; 24/06731-1 - Genetic variants associated with PTSD and their impact on neuroimaging changes in the amygdala, BP.IC; 24/06577-2 - Association between Genomic Variants and Psychiatric Disorders, Functional Deviations and Age of Onset, BP.IC; 23/14905-7 - Pharmacological and Non-Pharmacological Individual Interventions to Prevent Suicidal Attempt in Individuals Post-Acute Deliberate Self-Harm: Systematic Review and Meta-Analysis, BP.IC - associated scholarships

Abstract

The Center for Research and Innovation in Mental Health (Centro Nacional de Pesquisa e Inovação em Saúde Mental, CISM) represents a partnership between the University of São Paulo (USP), the Federal University of São Paulo (UNIFESP), the Federal University of Rio Grande do Sul (UFRGS), private investors (Banco Industrial do Brasil), and two City Halls from the state of São Paulo (Indaiatuba e Jaguariúna). Our mission is to advance knowledge concerning mental health conditions within the state of São Paulo and outlying regions, by introducing innovative interventions aimed at improving the wellbeing of these communities. The CISM has its embryogenic origin from the National Institute of Developmental Psychiatry (Instituto Nacional de Psiquiatria do Desenvolvimento, INPD). Our partnership with the Banco Industrial do Brasil will allow us to capitalize on private investments in cutting-edge science research. Our interaction with the City Halls of Indaiatuba and Jaguariúna will facilitate fruitful interaction with the Unified Health System (Sistema Único de Saúde, SUS) and will allow for the implementation of state-of-the-art interventions in these two municipalities in São Paulo. The CISM will specifically address three areas where knowledge gaps currently exist in our field. The first will advance research in precision medicine, mental health and population neuroscience. The second will increase the relevance of ongoing research, as an engine for the emergence of new ideas in digital mental health, innovation and entrepreneurship. The third, will increase technology transfer (TT) in mental health to society through a framework of implementation science. Over the next 10 years, CISM will create: (1) a Module for Precision Neuroscience, exponentially expanding the brain and behavior investigations of the Brazilian Transgenerational High Risk Cohort for Mental Conditions (BHRCS), which constitutes a robust database for the training of researchers and students; (2) a Module for the Assessment and Incubation of Digital Interventions in Mental Health, promoting technological innovations that can be accelerated by Banco Industrial do Brasil, to be used within the SUS and the university system; and (3) a Module for the Implementation of Science and Technology Transfer to the Society, bringing evidence-based interventions to society through implementation in the cities of Indaiatuba and Jaguariúna, with the support of their City Halls and a local private university (UniEduK). With the knowledge generated by the proposed work, specifically regarding the barriers and facilitators associated with these implementations, we will be in a position to scale-up these interventions and disseminate them to other cities both in and out of the State of São Paulo. The three modules will be supported by two action plans: the Action Plan for Technology Transfer, which will seek to transpose the results and associated advances of the proposed technological research to the market and society in general; and the Action Plan for Education and Dissemination of Knowledge, which will be responsible for disseminating scientific information to society and implementing new teaching methodologies. The CISM has the potential to transform mental health research in the country by making it more consistent, purposeful and socially oriented. To this end, the present CISM proposal will invest in studies of high added value, solidify partnerships in the public and private sectors in order to develop new ideas with innovative potential, and provide systematic interventions that will have a significant impact in the real world by influencing the lives of people who are in the most need of care in our communities. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DI SANTI, TALITA; NASCIMENTO, ARIANA GOMES; FUKUTI, PEDRO; MARCHISIO, VINNIE; DO AMARAL, GIAN CARLO ARAUJO; VAZ, CAMILLE FIGUEIREDO PETERNELLA; CARRIJO, LUIZ DAVID FINOTTI; DE OLIVEIRA, LILIAN CRISTIE; DA COSTA, LUIZ OCTAVIO; KONIECZNIAK, ELISANGELA MANCINI MARION; et al. Measuring Mental Health in 2 Brazilian University Centers: Protocol for a Cohort Survey. JMIR RESEARCH PROTOCOLS, v. 14, p. 10-pg., 2025-01-01. (21/05332-8, 21/12901-9)

ZUCCOLO, PEDRO F.; BRUNONI, ANDRE R.; BORJA, TATIANE; MATIJASEVICH, ALICIA; POLANCZYK, GUILHERME V.; FATORI, DANIEL. Efficacy of a Standalone Smartphone Application to Treat Postnatal Depression: A Randomized Controlled Trial. PSYCHOTHERAPY AND PSYCHOSOMATICS, v. 93, n. 6, p. 13-pg., 2024-10-23. (16/13451-9, 21/12439-3, 21/12901-9)

GOSLING, CORENTIN J.; CAPAROS, SERGE; PINABIAUX, CHARLOTTE; SCHWARZER, GUIDO; RUECKER, GERTA; AGHA, SHARIFAH S.; ALROUH, HEKMAT; AMBLER, ANTONY; ANDERSON, PETER; ANDIARENA, AINARA; et al. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. LANCET PSYCHIATRY, v. 10, n. 12, p. 12-pg., 2023-11-15. (21/12901-9, 14/50917-0)