Physical exercise and autonomic control in cardiovascular physiopathology

• Grant number: 05/59740-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2006
• End date: July 31, 2010
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Carlos Eduardo Negrão
• Grantee: Carlos Eduardo Negrão
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The aim of this thematic proposal is to investigate the effects of exercise on the cardiovascular physiopathology, which will be accomplished by studies in five subareas of the exercise cardiology and physiology. 1) Heart failure and acute coronariopathy. In this area of investigation, it will be studied the acute and chronic effects of exercise in a genetic model of heart failure by sympathetic overactivity on the heart and in patients with chronic heart failure, in a clear association between animal and human researches. Our expertise in autonomic control will be also used to study the neurovascular control during the acute phase of the myocardium infarction in humans. 2) Metabolic sindrome. In this area, it will be studied the impact of exercise training associated with hypocaloric diet or hypocaloric diet isolated on the mechanisms underlying the sympathoexcitation in patients with metabolic syndrome. The effects of exercise training and hypocaloric diet on the myocardium calcium transport and, in consequence, the ventricular function in obese rats will also be studied. 3) Effects of exercise training on autonomic control in individuals with polymorphism. In order to improve our understanding about genetic influence on the exercise-mediated cardiovascular adaptation, we will study the effects of acute and chronic exercise on cardiac hypertrophy and muscle vasodilatation in individuals with naturally occurring polymorphism in the angiotensin converting enzyme, angiotensinogen B2-adrenoceptors, and endothelial nitric oxide synthase. 4) Cardiac autonomic control in athletes and patients with neurocardiogenic syncope atrial fibrillation. In this area, we will investigate the autonomic adaptations provoked by chronic exercise during different periods of exercise training in athletes. In addition, we will study the effects of exercise training and postural training in patients with neurocardiogenic syncope. Finally, a new approach during eletrophysiological study in the treatment of atrial fibrillation will be tested. Exercise training, anabolic steroids and cardiovascular system. In this area, we will study the effects of exercise training associated with anabolic steroids on the cardiac remodeling, coronary blood flow, and cardiac and systemic renin-angiotensin system in rats. (AU)

Scientific publications

(26)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA, M. G.; FERREIRA, J. C. B.; BUENO, JR., C. R.; MATTOS, K. C.; ROSA, K. T.; IRIGOYEN, M. C.; OLIVEIRA, E. M.; KRIEGER, J. E.; BRUM, PATRICIA CHAKUR. Exercise training reduces cardiac angiotensin II levels and prevents cardiac dysfunction in a genetic model of sympathetic hyperactivity-induced heart failure in mice. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 105, n. 6, p. 843-850, APR 2009. (05/59740-7)

FERREIRA, JULIO C. B.; MOREIRA, JOSE B. N.; CAMPOS, JULIANE C.; PEREIRA, MARCELO G.; MATTOS, KATT C.; COELHO, MARCELE A.; BRUM, PATRICIA C.. Angiotensin receptor blockade improves the net balance of cardiac Ca2+ handling-related proteins in sympathetic hyperactivity-induced heart failure. Life Sciences, v. 88, n. 13-14, p. 578-585, MAR 28 2011. (05/59740-7, 09/03143-1)

DIAS, RODRIGO G.; ALVES, MARIA-JANIEIRE N. N.; PEREIRA, ALEXANDRE C.; RONDON, MARIA URBANA P. B.; DOS SANTOS, MARCELO R.; KRIEGER, JOSE E.; KRIEGER, MARTA H.; NEGRAO, CARLOS E.. Glu298Asp eNOS gene polymorphism causes attenuation in nonexercising muscle vasodilatation. Physiological Genomics, v. 37, n. 2, p. 99-107, APR 2009. (05/59740-7)

LATERZA, MATEUS C.; MATOS, LUCIANA D. N. J. DE; TROMBETTA, IVANI C.; BRAGA, ANA M. W.; ROVEDA, FABIANA; ALVES, MARIA J. N. N.; KRIEGER, EDUARDO M.; NEGRÃO, CARLOS E.; RONDON, MARIA U. P. B.. Exercise training restores baroreflex sensitivity in never-treated hypertensive patients. Hypertension, v. 49, n. 6, p. 1298-1306, June 2007. (01/00009-0, 05/59740-7)

SILVA, MICHELLE S. M.; BOLANI, WLADIMIR; ALVES, CLEBER R.; BIAGI, DIOGO G.; LEMOS, JR., JOSE R.; DA SILVA, JEFERSON L.; DE OLIVEIRA, PATRICIA A.; ALVES, GUILHERME B.; DE OLIVEIRA, EDILAMAR M.; NEGRAO, CARLOS E.; et al. Elimination of Influences of the ACTN3 R577X Variant on Oxygen Uptake by Endurance Training in Healthy Individuals. INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE, v. 10, n. 5, p. 636-641, JUL 2015. (05/59740-7)

NEGRAO, MARCELO V.; ALVES, CLEBER R.; ALVES, GUILHERME B.; PEREIRA, ALEXANDRE C.; DIAS, RODRIGO G.; LATERZA, MATEUS C.; MOTA, GLORIA F.; OLIVEIRA, EDILAMAR M.; BASSANEZE, VINICIUS; KRIEGER, JOSE E.; et al. Exercise training improves muscle vasodilatation in individuals with T786C polymorphism of endothelial nitric oxide synthase gene. Physiological Genomics, v. 42A, n. 1, p. 71-77, SEP 2010. (05/59740-7)

TROMBETTA, IVANI C.; SOMERS, VIREND K.; MAKI-NUNES, CRISTIANE; DRAGER, LUCIANO F.; TOSCHI-DIAS, EDGAR; ALVES, MARIA JANIEIRE N. N.; FRAGA, RAFFAEL F.; RONDON, MARIA URBANA P. B.; BECHARA, MALTA G.; LORENZI-FILHO, GERADO; et al. Consequences of Comorbid Sleep Apnea in the Metabolic Syndrome-Implications for Cardiovascular Risk. Sleep, v. 33, n. 9, p. 1193-1199, SEP 1 2010. (08/03714-6, 05/59740-7)

ALVES‚ M.J.N.N.; RONDON‚ M.U.P.B.; SANTOS‚ A.C.; DIAS‚ R.G.; BARRETTO‚ A.C.P.; KRIEGER‚ E.M.; MIDDLEKAUFF‚ H.R.; NEGRÃO‚ C.E.. Sympathetic nerve activity restrains reflex vasodilatation in heart failure. CLINICAL AUTONOMIC RESEARCH, v. 17, n. 6, p. 364-369, 2007. (01/00009-0, 05/59740-7)

MEDEIROS, ALESSANDRA; BIAGI, DIOGO G.; SOBREIRA, TIAGO J. P.; DE OLIVEIRA, PAULO SERGIO L.; NEGRAO, CARLOS EDUARDO; MANSUR, ALFREDO J.; KRIEGER, JOSE EDUARDO; BRUM, PATRICIA C.; PEREIRA, ALEXANDRE C.. Mutations in the human phospholamban gene in patients with heart failure. AMERICAN HEART JOURNAL, v. 162, n. 6, p. 1088-U184, DEC 2011. (05/59740-7)

DIAS, RODRIGO GONCALVES; MOREIRA SILVA, MICHELLE SABRINA; DUARTE, NUBIA ESTEBAN; BOLANI, WLADIMIR; ALVES, CLEBER RENE; LEMOS JUNIOR, JOSE RIBEIRO; DA SILVA, JEFERSON LUIS; DE OLIVEIRA, PATRICIA ALVES; ALVES, GUILHERME BARRETO; DE OLIVEIRA, EDILAMAR MENEZES; et al. PBMCs express a transcriptome signature predictor of oxygen uptake responsiveness to endurance exercise training in men. Physiological Genomics, v. 47, n. 2, p. 13-23, FEB 1 2015. (05/59740-7)

MOREIRA, HUMBERTO G.; LAGE, RONY L.; MARTINEZ, DANIEL G.; FERREIRA-SANTOS, LARISSA; RONDON, MARIA U. P. B.; NEGRAO, CARLOS E.; NICOLAU, JOSE C.. Sympathetic nervous activity in patients with acute coronary syndrome: a comparative study of inflammatory biomarkers. Clinical Science, v. 131, n. 9, p. 883-895, MAY 1 2017. (05/59740-7)

BUENO, JR., C. R.; FERREIRA, J. C. B.; PEREIRA, M. G.; BACURAU, A. V. N.; BRUM, P. C.. Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure. Journal of Applied Physiology, v. 109, n. 3, p. 702-709, SEP 2010. (05/59740-7, 09/03143-1)

GOWDAK, MARCIA M. G.; LATERZA, MATEUS C.; RONDON, MARIA URBANA P. B.; TROMBETTA, IVANI C.; PEREIRA, ALEXANDRE C.; KRIEGER, JOSE EDUARDO; NEGRAO, CARLOS EDUARDO. A high-fat meal impairs muscle vasodilatation response to mental stress in humans with Glu27 beta(2)-adrenoceptor polymorphism. LIPIDS IN HEALTH AND DISEASE, v. 9, JUN 2 2010. (05/59740-7)

NAZARE NUNES ALVES, MARIA JANIEIRE; DOS SANTOS, MARCELO RODRIGUES; DIAS, RODRIGO GONCALVES; AKIHO, CESAR ABREU; LATERZA, MATEUS CAMAROTI; PINTO BRANDAO RONDON, MARIA URBANA; DE MORAES MOREAU, REGINA LUCIA; NEGRAO, CARLOS EDUARDO. Abnormal Neurovascular Control in Anabolic Androgenic Steroids Users. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 42, n. 5, p. 865-871, MAY 2010. (05/59740-7)

LEMOS, JR., JOSE R.; ALVES, CLEBER R.; DE SOUZA, SILVIA B. C.; MARSIGLIA, JULIA D. C.; SILVA, MICHELLE S. M.; PEREIRA, ALEXANDRE C.; TEIXEIRA, ANTNIO L.; VIEIRA, ERICA L. M.; KRIEGER, JOSE E.; NEGRAO, CARLOS E.; et al. Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism. Physiological Genomics, v. 48, n. 2, p. 116-123, FEB 1 2016. (05/59740-7)

FERREIRA-SANTOS, LARISSA; MARTINEZ, DANIEL G.; NICOLAU, JOSE CARLOS; MOREIRA, HUMBERTO G.; ALVES, MARIA JANIEIRE; PEREIRA, ALEXANDRE C.; TROMBETTA, IVANI C.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B.. Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism of beta(2)-adrenergic receptor. PLoS One, v. 12, n. 2, FEB 24 2017. (10/50048-1, 05/59740-7)

ANTUNES-CORREA, LIGIA M.; MELO, RUTH C.; NOBRE, THAIS S.; UENO, LINDA M.; FRANCO, FABIO G. M.; BRAGA, ANA M. W.; RONDON, MARIA U. P. B.; BRUM, PATRICIA C.; BARRETTO, ANTONIO C. P.; MIDDLEKAUFF, HOLLY R.; et al. Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure. EUROPEAN JOURNAL OF HEART FAILURE, v. 12, n. 1, p. 58-65, JAN 2010. (05/59740-7)

NEGRAO, CARLOS E.; SANTOS, AMILTON C.; RONDON, MARIA U.; FRANCO, FABIO G.; IANNI, BARBARA; ROCHITTE, CARLOS E.; BRAGA, ANA M. F. W.; OLIVEIRA, JR., MUCIO T.; MADY, CHARLES; BARRETTO, ANTONIO C. P.; et al. Muscle sympathetic nerve activity in patients with Chagas' disease. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 137, n. 3, p. 252-259, NOV-DEC 2009. (05/59740-7)

UENO, LINDA M.; DRAGER, LUCIANO F.; RODRIGUES, ANA C. T.; RONDON, MARIA U. P. B.; BRAGA, ANA M. F. W.; MATHIAS, JR., WILSON; KRIEGER, EDUARDO M.; BARRETTO, ANTONIO C. P.; MIDDLEKAUFF, HOLLY R.; LORENZI-FILHO, GERALDO; et al. Effects of Exercise Training in Patients with Chronic Heart Failure and Sleep Apnea. Sleep, v. 32, n. 5, p. 637-647, MAY 1 2009. (05/59740-7)

MELLO, PRISCILA R.; GUERRA, GRAZI M.; BORILE, SUELLEN; RONDON, MARIA U.; ALVES, MARIA J.; NEGRAO, CARLOS E.; DAL LAGO, PEDRO; MOSTARDA, CRISTIANO; IRIGOYEN, MARIA C.; CONSOLIM-COLOMBO, FERNANDA M.. Inspiratory Muscle Training Reduces Sympathetic Nervous Activity and Improves Inspiratory Muscle Weakness and Quality of Life in Patients With Chronic Heart Failure A CLINICAL TRIAL. Journal of Cardiopulmonary Rehabilitation and Prevention, v. 32, n. 5, p. 255-261, SEP-OCT 2012. (05/59740-7)

MARTINEZ, DANIEL G.; NICOLAU, JOSE C.; LAGE, RONY L.; TOSCHI-DIAS, EDGAR; DE MATOS, LUCIANA D. N. J.; ALVES, MARIA JANIEIRE N. N.; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO J.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E.; et al. Effects of Long-Term Exercise Training on Autonomic Control in Myocardial Infarction Patients. Hypertension, v. 58, n. 6, p. 1049-U152, DEC 2011. (08/03714-6, 05/59740-7)

SILVA, BRUNO M.; NEVES, FABRICIA J.; NEGRAO, MARCELO V.; ALVES, CLEBER R.; DIAS, RODRIGO G.; ALVES, GUILHERME B.; PEREIRA, ALEXANDRE C.; RONDON, MARIA U.; KRIEGER, JOSE E.; NEGRAO, CARLOS E.; et al. Endothelial Nitric Oxide Synthase Polymorphisms and Adaptation of Parasympathetic Modulation to Exercise Training. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 43, n. 9, p. 1611-1618, SEP 2011. (05/59740-7)

BACURAU, ALINE V. N.; JARDIM, MAIRA A.; FERREIRA, JULIO C. B.; BECHARA, LUIZ R. G.; BUENO, JR., CARLOS R.; ALBA-LOUREIRO, TATIANA C.; NEGRAO, CARLOS E.; CASARINI, DULCE E.; CURI, RUI; RAMIRES, PAULO R.; et al. Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training. Journal of Applied Physiology, v. 106, n. 5, p. 1631-1640, MAY 2009. (06/56321-6, 05/59740-7)

ALVES, GUILHERME B.; OLIVEIRA, EDILAMAR M.; ALVES, CLEBER R.; RACHED, HERON R. S.; MOTA, GLORIA F. A.; PEREIRA, ALEXANDRE C.; RONDON, MARIA U.; HASHIMOTO, NARA Y.; AZEVEDO, LUCIENE F.; KRIEGER, JOSE EDUARDO; et al. Influence of angiotensinogen and angiotensin-converting enzyme polymorphisms on cardiac hypertrophy and improvement on maximal aerobic capacity caused by exercise training. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, v. 16, n. 4, p. 487-492, AUG 2009. (05/59740-7)

CASTRO‚ RRT; ANTUNES-CORREA‚ LM; UENO‚ LM; RONDON‚ M.; NEGRAO‚ CE; NÓBREGA‚ ACL. Reversal of periodic breathing after aerobic training in heart failure. European Respiratory Journal, v. 35, n. 6, p. 1409-1411, 2010. (05/59740-7)

NEGRAO‚ C.E.; MIDDLEKAUFF‚ H.R.. Adaptations in autonomic function during exercise training in heart failure. HEART FAILURE REVIEWS, v. 13, n. 1, p. 51-60, 2008. (05/59740-7)