Obsessive-Compulsive Disorder: pathogenesis and treatment

• Grant number: 99/12205-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2000
• End date: February 28, 2007
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Eurípedes Constantino Miguel Filho
• Grantee: Eurípedes Constantino Miguel Filho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Geraldo Busatto Filho ; Homero Pinto Vallada Filho
• Associated scholarship(s): 03/07451-6 - A genetic family study of children and adolescents with obsessive-compulsive disorder , BP.DR

Abstract

Obsessive-Compulsive Disease (OCD) is a chronic disorder, affects 2 to 3% of the general population (Karno & Golding, 1991) and appears independently of sex, race, intelligence, civil-state, socio-economic status, religion or nationality. Despite the increasing number of research and publications, OCD remains an enigma. Its pathophysiology and heterogeneity of symptoms and clinical course remains insoluble. On the search for these answers, clinical, psychopathological, genetic, neurophysiological, immunological, pharmacological and neuroimaging studies have been demonstrating that OCD is a heterogeneous disorder which encompasses groups of patients with peculiar characteristics to each subgroup (Miguel et al., 1995). This diversity leads us to determine more homogeneous subtypes of patients and search for predictive factors of response to treatment. We believe that only this way it will be possible to elucidate important factors in the pathogenesis and then develop more specific therapeutic interventions, both pharmacological and non-pharmacological (Coffey et al., 1994).This project intents to study OCD, under many aspects: On module 1, we intent to investigate the heritability of OCD in a sib-pairs study. On module 2, an epidemiological genetic study, we intent to investigate the presence of a genetic relation between OCD and some diseases more commonly associated to it and Rheumatic Fever, a clinical disease that involves a streptococcal infection and lies been associated to OCD and to Tourette Syndrome. On module 3, a pharmacogenetic study, we are going to evaluate if there are genetic differences between responsive or non-responsive groups to clomipramine. On module 4, we are going to study the percentage of expression of D8/17 (a lymphocyte antigen that is found in almost 100% of patients with RF) in normal individuals, with OCD, OCD and RF, and RF alone (patients from module 1, 2 and 6).On module 5, we will investigate the cerebral blood flow of patients with OCD and RF (patients from module 2) to verify if there is any difference between flow patterns in comparison with patients with OCD without RF studied before. On module 6, we are going to investigate predictive factors of response to OCD treatment with clomipramine. This project gives also important emphasis on formation and training of new researchers as wellas on the development of young doctors on the beginning of their careers... (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSELI G SHAVITT; YGOR A FERRÃO; MARIA CLAUDIA BRAVO; CRISTINA BELOTTO; ADEMIR LOPES JUNIOR; EURÍPEDES C MIGUEL. Transtorno obsessivo-compulsivo resistente: conceito e estratégias de tratamento. Revista Brasileira de Psiquiatria, v. 23, p. 52-57, 2001-10-00. (99/12205-7)

HOUNIE‚ A.G.; PAULS‚ D.L.; DO ROSARIO-CAMPOS‚ M.C.; MERCADANTE‚ M.T.; DINIZ‚ J.B.; DE MATHIS‚ M.A.; DE MATHIS‚ M.E.; CHACON‚ P.; SHAVITT‚ R.G.; CURI‚ M.; et al. Obsessive-compulsive spectrum disorders and rheumatic fever: a family study. BIOLOGICAL PSYCHIATRY, v. 61, n. 3, p. 266-272, 2007. (99/12205-7)

MIGUITA, KAREN; CORDEIRO, QUIRINO; SHAVITT, ROSELI GEDANKE; MIGUEL, EURPEDES CONSTANTINO; VALLADA, HOMERO. Estudo de associação entre polimorfismos genéticos monoaminérgicos e resposta à clomipramina no tratamento do TOC. Arquivos de Neuro-Psiquiatria, v. 69, n. 2B, p. 283-287, APR 2011. (99/12205-7)

MORSHED‚ S.A.; PARVEEN‚ S.; LECKMAN‚ J.F.; MERCADANTE‚ M.T.; BITTENCOURT KISS‚ M.H.; MIGUEL‚ E.C.; ARMAN‚ A.; YAZGAN‚ Y.; FUJII‚ T.; PAUL‚ S.; et al. Antibodies against neural‚ nuclear‚ cytoskeletal‚ and streptococcal epitopes in children and adults with Tourette’s syndrome‚ Sydenham’s chorea‚ and autoimmune disorders. BIOLOGICAL PSYCHIATRY, v. 50, n. 8, p. 566-577, 2001. (99/12205-7)

ANTONIO CARLOS LOPES; MARIA EUGÊNIA DE MATHIS; MIGUEL MONTES CANTERAS; JOÃO VICTOR SALVAJOLI; JOSÉ ALBERTO DEL PORTO; EURÍPEDES CONSTANTINO MIGUEL. Atualização sobre o tratamento neurocirúrgico do transtorno obsessivo-compulsivo. Revista Brasileira de Psiquiatria, v. 26, n. 1, p. 62-66, 2004-03-00. (99/12205-7)

J.A.S. CRIPPA; R. UCHIDA; G.F. BUSATTO; F.S. GUIMARÃES; C.M. DEL-BEN; A.W. ZUARDI; A.C. SANTOS; D. ARAÚJO; P.K. MCGUIRE; F.G. GRAEFF. The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder. Brazilian Journal of Medical and Biological Research, v. 37, n. 3, p. 371-374, 2004-03-00. (99/12205-7, 98/10639-7, 02/13197-2)

SEIXAS‚ AA; HOUNIE‚ A.G.; FOSSALUZA‚ V.; CURI‚ M.; ALVARENGA‚ P.G.; DE MATHIS‚ M.A.; DE MATHIS‚ ME; VALLADA‚ H.; PAULS‚ D.; DE BRAGANÇA‚ P.C.A.; et al. Anxiety disorders and rheumatic fever: is there an association?. CNS SPECTRUMS, v. 13, n. 12, p. 1039-46, 2008. (99/12205-7)

CRIPPA‚ J.A.S.; ZUARDI‚ A.W.; BUSATTO‚ G.F.; SANCHES‚ R.F.; SANTOS‚ A.C.; ARAÚJO‚ D.; AMARO‚ E.; HALLAK‚ J.E.C.; NG‚ V.; MCGUIRE‚ P.K.. Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. EUROPEAN PSYCHIATRY, v. 21, n. 5, p. 291-299, 2006. (98/10639-7, 99/12205-7, 02/13197-2)

VALENTE‚ A.A.; MIGUEL‚ E.C.; CASTRO‚ C.C.; AMARO‚ E.; DURAN‚ F.L.S.; BUCHPIGUEL‚ C.A.; CHITNIS‚ X.; MCGUIRE‚ P.K.; BUSATTO‚ G.F.; OTHERS. Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. BIOLOGICAL PSYCHIATRY, v. 58, n. 6, p. 479-487, 2005. (99/12205-7)