Study of alterations occurred in the adenoma during the process of malignization in ex-adenoma pleomorphic carcinoma

• Grant number: 04/07960-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: January 01, 2005
• End date: December 31, 2008
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Vera Cavalcanti de Araujo
• Grantee: Vera Cavalcanti de Araujo
• Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
• Pesquisadores principais: Albina Messias de Almeida Milani Altemani
• Associated research grant(s): 09/08875-0 - 22nd European Congress of Pathology, AR.EXT

Abstract

Carcinoma ex-pleomorphic adenoma (CXAP) is a salivary gland tumor resulting from a malignant transformation of pleomorphic adenoma, usually recurrent or of long duration. It accounts for 5 to10% of all salivary gland tumors. It is considered a high grade tumor with frequent metastasis and death. Since it is a rare malignant transformation of a benign tumor, the CXAP is an interesting model for studying the events that take place during the malignant transformation, such as the acquired metastasis, the alteration of cellular phenotype, the modification of the environment, the occurrence of anti-invasive and invasive components and the chromosome alteration related to the material loss and gain. The aim of this project is to study the CXPA according to the following subjects: 1) iImmunohistochemical profile of tumoral cells in relation to: 1.1) cytoskeleton proteins; 1.2) adhesion proteins: cadherin and catenin; 1.3) inhibitor of protease: Maspin; 2) immunohistochemical profile of tumoral stroma; 3) study of tumor oncogenes and suppressor genes; 4) analysis of genetic alterations by comparative genomic hybridization. All the results will be analyzed by comparing the benign area with the malignant area and, when it exists, with the transitional area. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LUCYENE MIGUITA; ELIZABETH FERREIRA MARTINEZ; NEY SOARES DE ARAÚJO; VERA CAVALCANTI DE ARAÚJO. FGF-2, TGFβ-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. Journal of Applied Oral Science, v. 18, n. 1, p. 83-91, 2010-02-00. (04/07960-0)

MARTINEZ, ELIZABETH F.; DEMASI, ANA P. D.; MIGUITA, LUCYENE; ALTEMANI, ALBINA; ARAUJO, NEY S.; ARAUJO, VERA C.. FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. ONCOLOGY REPORTS, v. 24, n. 1, p. 155-160, JUL 2010. (04/07960-0)

MIGUITA, LUCYENE; MARTINEZ, ELIZABETH FERREIRA; DE ARAUJO, NEY SOARES; DE ARAUJO, VERA CAVALCANTI. FGF-2, TGF beta-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. Journal of Applied Oral Science, v. 18, n. 1, p. 83-91, JAN-FEB 2010. (04/07960-0)

ALTEMANI, A.; MARTINS, M. T.; FREITAS, L.; SOARES, F.; ARAÚJO, N. S.; ARAÚJO, V. C.. Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology, v. 46, n. 6, p. 635-641, June 2005. (04/07960-0)

MARTINS, M. T.; ALTEMANI, A.; FREITAS, L.; ARAÚJO, V. C.. Maspin expression in carcinoma ex pleomorphic adenoma. Journal of Clinical Pathology, v. 58, n. 12, p. 1311-1314, Dec. 2005. (04/07960-0)

ARAÚJO, VERA CAVALCANTI DE; ALTEMANI, ALBINA; FURUSE, CRISTIANE; MARTINS, MARÍLIA TRIERVEILER; ARAÚJO, NEY SOARES DE. Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncology, v. 42, n. 10, p. 1011-1016, Nov. 2006. (04/07960-0)

SOARES, A. B.; JULIANO, P. B.; ARAUJO, V. C.; METZE, K.; ALTEMANI, A.. Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma. Virchows Archiv, v. 451, n. 1, p. 65-71, July 2007. (04/07960-0)

DE ARAUJO‚ V.C.; FURUSE‚ C.; CURY‚ P.R.; ALTEMANI‚ A.; ALVES‚ V.A.F.; DE ARAÚJO‚ N.S.. Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 16, n. 1, p. 48-53, 2008. (04/07960-0)

FURUSE, CRISTIANE; MIGUITA, LUCYENE; GARCIA ROSA, ANA CLAUDIA; SOARES, ANDRESA BORGES; MARTINEZ, ELIZABETH FERREIRA; ALTEMANI, ALBINA; DE ARAUJO, VERA CAVALCANTI. Study of growth factors and receptors in carcinoma ex pleomorphic adenoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 39, n. 7, p. 540-547, AUG 2010. (04/07960-0)

SOARES, A. B.; PONCHIO, L.; JULIANO, P. B.; ARAÚJO, V. C. DE; ALTEMANI, A.. Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma. Journal of Clinical Pathology, v. 60, n. 9, p. 995-1000, Sept. 2007. (04/07960-0)

DE ARAUJO, VERA CAVALCANTI; FURUSE, CRISTIANE; CURY, PATRICIA RAMOS; ALTEMANI, ALBINA; FERREIRA ALVES, VENANCIO AVANCINI; DE ARAUJO, NEY SOARES. Desmoplasia in Different Degrees of Invasion of Carcinoma Ex-Pleomorphic Adenoma. Head and Neck Pathology, v. 1, n. 2, p. 6-pg., 2007-12-01. (04/07960-0)