Epithelial-mesenchymal transition in breast carcinogenesis

• Grant number: 08/09294-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2009
• End date: August 31, 2011
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Daniel Guimarães Tiezzi
• Grantee: Daniel Guimarães Tiezzi
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The breast cancer is the most common and lethal malignant neoplasm, affecting people worldwide. Studies have showed that the rupture of basal membrane and the myoepithelial cells layer is a precocious sign of a clone cells formation responsible for the process of invasion. To infiltrate the stroma and to access the lymphatic and blood vessels, malignant epithelial cells must deactivate cell-to-cell adhesion mechanisms and acquire locomotive properties. This biological phenomenon has been reported as epithelial-mesenchymal transition (EMT). Genes first described as important in the control of embryogenesis as Twist-1 and Snail-2 (Slug) have been described as important factors of the breast cancer prognostic and progression. The activation of transcription factors Twist and Snail can induce genetic alteration in differentiated mammary epithelial cells leading to a specific phenotype that resembles a primordial cell (CD133+) described as cancer stem cell (CSC). The identification of specific CSC proteins expression as well as the overexpression of Twist transcription factors in areas of initial invasion can supply unknown information about the mechanisms of invasion and metastasis in breast cancer. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DANIEL GUIMARÃES TIEZZI; WILLIAN SIMÕES CLAGNAN; LARISSA RAQUEL MOURO MANDARANO; CHRISTIANI BISINOTO DE SOUSA; HEITOR RICARDO COSISKI MARANA; MARCELO GUIMARÃES TIEZZI; JURANDYR MOREIRA DE ANDRADE. Expression of aldehyde dehydrogenase after neoadjuvant chemotherapy is associated with expression of hypoxia-inducible factors 1 and 2 alpha and predicts prognosis in locally advanced breast cancer. Clinics, v. 68, n. 5, p. 592-598, 2013-05-00. (08/09294-9)

TIEZZI‚ D.G.; VALEJO‚ F.A.M.; MARANA‚ H.R.C.; CARRARA‚ H.H.A.; BENEVIDES‚ L.; ANTONIO‚ H.M.R.; SICCHIERI‚ R.D.; MILANEZI‚ C.M.; SILVA‚ J.S.; DE ANDRADE‚ J.M.. CD44+/CD24- cells and lymph node metastasis in stage I and II invasive ductal carcinoma of the breast. MEDICAL ONCOLOGY, p. 1-7, 2011. (08/09294-9)

ORLANDIN, LEONARDO FLEURY; CANDID DOS REIS, FRANCISCO JOSE; DA SILVEIRA, WILLIAN ABRAHAM; TIEZZI, MARCELO GUIMARAES; DE ANDRADE, JURANDYR MOREIRA; RIBEIRO-SILVA, LFREDO; DEATON, RYAN; BOSLAND, MAARTEN; TIEZZI, ANIEL GUIMARAES. Identification of a Subtype of Poorly Differentiated Invasive Ductal Carcinoma of the Breast Based on Vimentin and E-cadherin Expression. Revista Brasileira de Ginecologia e Obstetrícia, v. 40, n. 12, p. 779-786, DEC 2018. (08/09294-9)

TIEZZI, DANIEL GUIMARAES; MOURAO VALEJO, FERNANDO ANTONIO; COSINSKI MARANA, HEITOR RICARDO; ANGOTTI CARRARA, HELIO HUMBERTO; BENEVIDES, LUCIANA; RIBEIRO ANTONIO, HERITON MARCELO; SICCHIERI, RENATA DANIELLE; MILANEZI, CRISTIANE MARIA; DA SILVA, JOAO SANTANA; DE ANDRADE, JURANDYR MOREIRA. CD44(+)/CD24(-) cells and lymph node metastasis in stage I and II invasive ductal carcinoma of the breast. MEDICAL ONCOLOGY, v. 29, n. 3, p. 1479-1485, SEP 2012. (08/09294-9)