Abstract
Until recently, gastrointestinal motility has been studied using invasive methods. On the other hand, work from members of our team has led to the development of harmless, non-invasive biomagnetic techniques and new materials, which have been successfully, applied in gastrointestinal motility studies. Hence, conventional and novel methods could be employed to improve the knowledge on the regulation of gastrointestinal function and, consequently, its dysfunctions. This research project aims at refining current non-invasive methods for the study of gastric motility, to improve biomagnetic techniques developed locally and, particularly, to apply these methodological innovations in the investigation of specific aspects of gastrointestinal physiology and pathophysiology as well as its relationships with drug delivery following the administration of solid dosage forms. This project will be developed into four stages: clinical, experimental models, biopharmaceutical, sensors and materials. A number of specific subprojects involving a range of methodological approaches in different studies in healthy volunteers and patients as well as animal and in vitro studies will be carried out to fulfill the more general objective of expanding the knowledge on the field. (AU)
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