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Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas

Grant number: 10/51168-0
Support type:Research Projects - Thematic Grants
Duration: November 01, 2010 - December 31, 2015
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Eloiza Helena Tajara da Silva
Grantee:Eloiza Helena Tajara da Silva
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Co-Principal Investigators:André Lopes Carvalho
Associated scholarship(s):11/21395-8 - Functional analysis of cell signaling involvement in cancer stem cells obtained from oral squamous cell carcinoma cell lines, BP.PD
11/23353-0 - Analysis of glycosylated proteins and metabolites in oral squamous cell carcinomas, BP.PD
11/03281-5 - Evaluation of expression of macrophage migration inhibitory factor (MIF) as prognostic marker in patients with oral squamous cell carcinoma, BP.MS
11/13315-4 - Large-scale study of transcriptional alterations associated with the development of metastasis in oral cancer, BP.DR
10/18581-1 - Molecular profile of oral squamous cell carcinoma with linfonodal mtastasis: microarray and functional analysis, BP.PD

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent neoplasias and its main risk factors are alcohol and tobacco exposure. Despite intense research and recent advances in detection and therapeutic strategies, the five-year survival rate remains low in this group of tumors. Recent publications suggest that HPV infection is related to head and neck tumor genesis and may alter the tumor profile and outcome. Clinical, histopathological and molecular factors have been associated with prognosis of HN cancer, including the presence of lymph node metastasis, abnormal gene methylation and abnormal expression of genes and proteins involved in critical cellular of processes. The present study aims to investigate lifestyle factors, HPV infection, as well as gene and protein expression patterns and clinical, histopathological and molecular factors associated with development and prognosis of HNSCC. After integration of the data, the study also aims to develop a predictive model to identify patients at risk for morbid events, including regional and distant metastasis, low global and disease-free survival and second primary tumors. This project represents the first initiative to obtain financial support to organize a Brazilian research network to study head and neck cancer, which will be integrated into the international network InterCHANGE. (AU)

Articles published in Agência FAPESP about the research grant
Antidiabetic drug is tested against head and neck cancer 
Genetic variants are associated with susceptibility to mouth and throat cancer 
Articles published in Revista Pesquisa FAPESP about the project
The new faces of cancer 

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEONCINI, EMANUELE; VUKOVIC, VLADIMIR; CADONI, GABRIELLA; GIRALDI, LUCA; PASTORINO, ROBERTA; ARZANI, DARIO; PETRELLI, LIVIA; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA NATASHA; MOYSES, RAQUEL AYUB; MATSUO, KEITARO; BOSETTI, CRISTINA; LA VECCHIA, CARLO; SERRAINO, DIEGO; SIMONATO, LORENZO; MERLETTI, FRANCO; BOFFETTA, PAOLO; HASHIBE, MIA; LEE, YUAN-CHIN AMY; BOCCIA, STEFANIA. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. EUROPEAN JOURNAL OF EPIDEMIOLOGY, v. 33, n. 12, p. 1205-1218, DEC 2018. Web of Science Citations: 1.
PERDOMO, SANDRA; ANANTHARAMAN, DEVASENA; FOLL, MATTHIEU; ABEDI-ARDEKANI, BEHNOUSH; DURAND, GEOFFROY; ROSA, LUCIANA ALBINA REIS; HOLMILA, REETTA; LE CALVEZ-KELM, FLORENCE; TAJARA, ELOIZA H.; WUNSCH-FILHO, VICTOR; LEVI, JOSE EDUARDO; VILENSKY, MARTA; POLESEL, JERRY; HOLCATOVA, IVANA; SIMONATO, LORENZO; CANOVA, CRISTINA; LAGIOU, PAGONA; MCKAY, JAMES D.; BRENNAN, PAUL. Genomic analysis of head and neck cancer cases from two high incidence regions. PLoS One, v. 13, n. 1 JAN 29 2018. Web of Science Citations: 1.
GIRALDI, L.; LEONCINI, E.; PASTORINO, R.; WUNSCH-FILHO, V.; DE CARVALHO, M.; LOPEZ, R.; CADONI, G.; ARZANI, D.; PETRELLI, L.; MATSUO, K.; BOSETTI, C.; LA VECCHIA, C.; GARAVELLO, W.; POLESEL, J.; SERRAINO, D.; SIMONATO, L.; CANOVA, C.; RICHIARDI, L.; BOFFETTA, P.; HASHIBE, M.; LEE, Y. C. A.; BOCCIA, S. Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Annals of Oncology, v. 28, n. 11, p. 2843-2851, NOV 2017. Web of Science Citations: 11.
ANANTHARAMAN, DEVASENA; ABEDI-ARDEKANI, BEHNOUSH; BEACHLER, DANIEL C.; GHEIT, TARIK; OLSHAN, ANDREW F.; WISNIEWSKI, KATHY; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; TAJARA, ELOIZA H.; LEVI, JOSE EDUARDO; MOYSES, RAQUEL A.; BOCCIA, STEFANIA; CADONI, GABRIELLA; RINDI, GUIDO; AHRENS, WOLFGANG; MERLETTI, FRANCO; CONWAY, DAVID I.; WRIGHT, SYLVIA; CARREIRA, CHRISTINE; RENARD, HELENE; CHOPARD, PRISCILIA; MCKAY-CHOPIN, SANDRINE; SCELO, GHISLAINE; TOMMASINO, MASSIMO; BRENNAN, PAUL; D'SOUZA, GYPSYAMBER. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, v. 140, n. 9, p. 1968-1975, MAY 1 2017. Web of Science Citations: 22.
LESSEUR, CORINA; DIERGAARDE, BRENDA; OLSHAN, ANDREW F.; WUNSCH-FILHO, VICTOR; NESS, ANDREW R.; LIU, GEOFFREY; LACKO, MARTIN; ELUF-NETO, JOSE; FRANCESCHI, SILVIA; LAGIOU, PAGONA; MACFARLANE, GARY J.; RICHIARDI, LORENZO; BOCCIA, STEFANIA; POLESEL, JERRY; KJAERHEIM, KRISTINA; ZARIDZE, DAVID; JOHANSON, MATTIAS; MENEZES, ANA M.; CURADO, MARIA PAULA; ROBINSON, MAX; AHRENS, WOLFGANG; CANOVA, CRISTINA; ZNAOR, ARIANA; CASTELLSAGUE, XAVIER; CONWAY, DAVID I.; HOLCATOVA, IVANA; MATES, DANA; VIDENSKY, MARTA; HEALY, CLAIRE M.; SZESZENIA-DBROWSKA, NEONILA; FABIANOVA, ELEONORA; LISSOWSKA, JOLANTA; GRANDIS, JENNIFER R.; WEISSLER, MARK C.; TAJARA, ELOIZA H.; NUNES, FABIO D.; DE CARVALHO, MARCOS B.; THOMAS, STEVE; HUNG, RAYJEAN J.; PETERS, WILBERT H. M.; HERRERO, ROLANDO; CADONI, GABRIELLA; BUENO-DE-MESQUITA, H. BAS; STEFFEN, ANNIKA; AGUDO, ANTONIO; SHANGINA, OXANA; XIAO, XIANGJUN; GABORIEAU, VALERIE; CHABRIER, AMELIE; ANANTHARAMAN, DEVASENA; BOFFETTA, PAOLO; AMOS, CHRISTOPHER I.; MCKAY, JAMES D.; BRENNAN, PAUL. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nature Genetics, v. 48, n. 12, p. 1544-1550, DEC 2016. Web of Science Citations: 31.
DE OLIVEIRA FIGUEIREDO, REJANE AUGUSTA; WEIDERPASS, ELISABETE; TAJARA, ELOIZA HELENA; STROM, PETER; CARVALHO, ANDRE LOPES; DE CARVALHO, MARCOS BRASILINO; KANDA, JOSSI LEDO; MOYSES, RAQUEL AJUB; WUNSCH-FILHO, VICTOR. Diabetes mellitus, metformin and head and neck cancer. Oral Oncology, v. 61, p. 47-54, OCT 2016. Web of Science Citations: 5.
BERTHILLER, JULIEN; STRAIF, KURT; AGUDO, ANTONIO; AHRENS, WOLFGANG; DOS SANTOS, ALEXANDRE BEZERRA; BOCCIA, STEFANIA; CADONI, GABRIELLA; CANOVA, CRISTINA; CASTELLSAGUE, XAVIER; CHEN, CHU; CONWAY, DAVID; CURADO, MARIA PAULA; DAL MASO, LUIGINO; DAUDT, ALEXANDER W.; FABIANOVA, ELEONORA; FERNANDEZ, LETICIA; FRANCESCHI, SILVIA; FUKUYAMA, ERICA E.; HAYES, RICHARD B.; HEALY, CLAIRE; HERRERO, ROLANDO; HOLCATOVA, IVANA; KELSEY, KARL; KJAERHEIM, KRISTINA; KOIFMAN, SERGIO; LAGIOU, PAGONA; LA VECCHIA, CARLO; LAZARUS, PHILIP; LEVI, FABIO; LISSOWSKA, JOLANTA; MACFARLANE, TATIANA; MATES, DANA; MCCLEAN, MICHAEL; MENEZES, ANA; MERLETTI, FRANCO; MORGENSTERN, HAL; MUSCAT, JOSHUA; OLSHAN, ANDREW F.; PURDUE, MARK; RAMROTH, HERIBERT; RUDNAI, PETER; SCHWARTZ, STEPHEN M.; SERRAINO, DIEGO; SHANGINA, OXANA; SMITH, ELAINE; STURGIS, ERICH M.; SZESZENIA-DABROWSKA, NEONILA; THOMSON, PETER; VAUGHAN, THOMAS L.; VILENSKY, MARTA; WEI, QINGYI; WINN, DEBORAH M.; WUNSCH-FILHO, VICTOR; ZHANG, ZUO-FENG; ZNAOR, ARIANA; FERRO, GILLES; BRENNAN, PAUL; BOFFETTA, PAOLO; HASHIBE, MIA; LEE, YUAN-CHIN AMY. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis. International Journal of Epidemiology, v. 45, n. 3, p. 835-845, JUN 2016. Web of Science Citations: 11.
HENRIQUE, TIAGO; FREITAS DA SILVEIRA, NELSON JOSE; CUNHA VOLPATO, ARTHUR HENRIQUE; MIOTO, MAYRA MATARUCO; BUZZO STEFANINI, ANA CAROLINA; FARES, ADIL BACHIR; DA SILVA CASTRO ANDRADE, JOAO GUSTAVO; MASSON, CAROLINA; MENDOZA LOPEZ, ROSSANA VERONICA; NUNES, FABIO DAUMAS; KOWALSKI, LUIS PAULO; SEVERINO, PATRICIA; TAJARA, ELOIZA HELENA. u HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, MAR 24 2016. Web of Science Citations: 2.
SEVERINO, PATRICIA; OLIVEIRA, LILIANE SANTANA; ANDREGHETTO, FLAVIA MAZIERO; TORRES, NATALIA; CURIONI, OTAVIO; CURY, PATRICIA MALUF; TOPORCOV, TATIANA NATASHA; PASCHOAL, ALEXANDRE ROSSI; DURHAM, ALAN MITCHELL. Small RNAs in metastatic and non-metastatic oral squamous cell carcinoma. BMC MEDICAL GENOMICS, v. 8, JUN 24 2015. Web of Science Citations: 17.
ARANTES, L. M. R. B.; DE CARVALHO, A. C.; MELENDEZ, M. E.; CENTRONE, C. C.; GOIS-FILHO, J. F.; TOPORCOV, T. N.; CALY, D. N.; TAJARA, E. H.; GOLONI-BERTOLLO, E. M.; CARVALHO, A. L.; GENCAPO. Validation of methylation markers for diagnosis of oral cavity cancer. EUROPEAN JOURNAL OF CANCER, v. 51, n. 5, p. 632-641, MAR 2015. Web of Science Citations: 20.
TOPORCOV, TATIANA NATASHA; ZNAOR, ARIANA; ZHANG, ZUO-FENG; YU, GUO-PEI; WINN, DEBORAH M.; WEI, QINGYI; VILENSKY, MARTA; VAUGHAN, THOMAS; THOMSON, PETER; TALAMINI, RENATO; SZESZENIA-DABROWSKA, NEONILA; STURGIS, ERICH M.; SMITH, ELAINE; SHANGINA, OXANA; SCHWARTZ, STEPHEN M.; SCHANTZ, STIMSON; RUDNAI, PETER; RICHIARDI, LORENZO; RAMROTH, HERIBERT; PURDUE, MARK P.; OLSHAN, ANDREW F.; ELUF-NETO, JOSE; MUSCAT, JOSHUA; MOYSES, RAQUEL AJUB; MORGENSTERN, HAL; MENEZES, ANA; MCCLEAN, MICHAEL; MATSUO, KEITARO; MATES, DANA; MACFARLANE, TATIANA V.; LISSOWSKA, JOLANTA; LEVI, FABIO; LAZARUS, PHILIP; LA VECCHIA, CARLO; LAGIOU, PAGONA; KOIFMAN, SERGIO; KJAERHEIM, KRISTINA; KELSEY, KARL; HOLCATOVA, IVANA; HERRERO, ROLANDO; HEALY, CLAIRE; HAYES, RICHARD B.; FRANCESCHI, SILVIA; FERNANDEZ, LETICIA; FABIANOVA, ELEONORA; DAUDT, ALEXANDER W.; CURIONI, OTAVIO ALBERTO; DAL MASO, LUIGINO; CURADO, MARIA PAULA; CONWAY, DAVID I.; CHEN, CHU; CASTELLSAGUE, XAVIER; CANOVA, CRISTINA; CADONI, GABRIELLA; BRENNAN, PAUL; BOCCIA, STEFANIA; ANTUNES, JOSE LEOPOLDO FERREIRA; AHRENS, WOLFGANG; AGUDO, ANTONIO; BOFFETTA, PAOLO; HASHIBE, MIA; LEE, YUAN-CHIN AMY; WUENSCH FILHO, VICTOR. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. International Journal of Epidemiology, v. 44, n. 1, p. 169-185, FEB 2015. Web of Science Citations: 44.
STEFANINI, ANA CAROLINA B.; DA CUNHA, BIANCA RODRIGUES; HENRIQUE, TIAGO; TAJARA, ELOIZA H. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. DISEASE MARKERS, 2015. Web of Science Citations: 11.
SEVERINO, PATRICIA; OLIVEIRA, LILIANE SANTANA; TORRES, NATALIA; ANDREGHETTO, FLAVIA MAZIERO; GUARIZO KLINGBEIL, MARIA DE FATIMA; MOYSES, RAQUEL; WUENSCH-FILHO, VICTOR; NUNES, FABIO DAUMAS; MATHOR, MONICA BEATRIZ; PASCHOAL, ALEXANDRE ROSSI; DURHAM, ALAN MITCHELL. High-throughput sequencing of small RNA transcriptomes reveals critical biological features targeted by microRNAs in cell models used for squamous cell cancer research. BMC Genomics, v. 14, OCT 26 2013. Web of Science Citations: 11.

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