Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas

• Grant number: 10/51168-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2010
• End date: December 31, 2015
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Eloiza Helena Tajara da Silva
• Grantee: Eloiza Helena Tajara da Silva
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Pesquisadores principais: André Lopes Carvalho
• Associated scholarship(s): 11/21395-8 - Functional analysis of cell signaling involvement in cancer stem cells obtained from oral squamous cell carcinoma cell lines, BP.PD; 11/23353-0 - Analysis of glycosylated proteins and metabolites in oral squamous cell carcinomas, BP.PD; 11/03281-5 - Evaluation of expression of macrophage migration inhibitory factor (MIF) as prognostic marker in patients with oral squamous cell carcinoma, BP.MS; 11/13315-4 - Large-scale study of transcriptional alterations associated with the development of metastasis in oral cancer., BP.DR; 10/18581-1 - Molecular profile of oral squamous cell carcinoma with linfonodal mtastasis: microarray and functional analysis, BP.PD

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent neoplasias and its main risk factors are alcohol and tobacco exposure. Despite intense research and recent advances in detection and therapeutic strategies, the five-year survival rate remains low in this group of tumors. Recent publications suggest that HPV infection is related to head and neck tumor genesis and may alter the tumor profile and outcome. Clinical, histopathological and molecular factors have been associated with prognosis of HN cancer, including the presence of lymph node metastasis, abnormal gene methylation and abnormal expression of genes and proteins involved in critical cellular of processes. The present study aims to investigate lifestyle factors, HPV infection, as well as gene and protein expression patterns and clinical, histopathological and molecular factors associated with development and prognosis of HNSCC. After integration of the data, the study also aims to develop a predictive model to identify patients at risk for morbid events, including regional and distant metastasis, low global and disease-free survival and second primary tumors. This project represents the first initiative to obtain financial support to organize a Brazilian research network to study head and neck cancer, which will be integrated into the international network InterCHANGE. (AU)

Scientific publications

(30)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

STEFANINI, ANA CAROLINA B.; DA CUNHA, BIANCA RODRIGUES; HENRIQUE, TIAGO; TAJARA, ELOIZA H.. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. DISEASE MARKERS, 2015. (10/51168-0)

HENRIQUE, TIAGO; FREITAS DA SILVEIRA, NELSON JOSE; CUNHA VOLPATO, ARTHUR HENRIQUE; MIOTO, MAYRA MATARUCO; BUZZO STEFANINI, ANA CAROLINA; FARES, ADIL BACHIR; DA SILVA CASTRO ANDRADE, JOAO GUSTAVO; MASSON, CAROLINA; MENDOZA LOPEZ, ROSSANA VERONICA; NUNES, FABIO DAUMAS; et al. u HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, MAR 24 2016. (10/51168-0)

ANANTHARAMAN, DEVASENA; ABEDI-ARDEKANI, BEHNOUSH; BEACHLER, DANIEL C.; GHEIT, TARIK; OLSHAN, ANDREW F.; WISNIEWSKI, KATHY; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; TAJARA, ELOIZA H.; LEVI, JOSE EDUARDO; et al. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, v. 140, n. 9, p. 1968-1975, MAY 1 2017. (10/51168-0, 04/12054-9)

KHETAN, PRERNA; BOFFETTA, PAOLO; LUCE, DANIELE; STUCKER, ISABELLE; CURADO, MARIA PAULA; MENEZES, ANA; WUNSCH-FILHO, VICTOR; AHRENS, WOLFGANG; LAGIOU, PAGONA; SERRAINO, DIEGO; et al. Occupations and the Risk of Head and Neck Cancer A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, v. 61, n. 5, p. 397-404, MAY 2019. (10/51168-0, 04/12054-9)

DE OLIVEIRA FIGUEIREDO, REJANE AUGUSTA; WEIDERPASS, ELISABETE; TAJARA, ELOIZA HELENA; STROM, PETER; CARVALHO, ANDRE LOPES; DE CARVALHO, MARCOS BRASILINO; KANDA, JOSSI LEDO; MOYSES, RAQUEL AJUB; WUNSCH-FILHO, VICTOR. Diabetes mellitus, metformin and head and neck cancer. Oral Oncology, v. 61, p. 47-54, OCT 2016. (10/51168-0, 13/20548-0, 13/21702-3, 14/18893-4)

ARANTES, L. M. R. B.; DE CARVALHO, A. C.; MELENDEZ, M. E.; CENTRONE, C. C.; GOIS-FILHO, J. F.; TOPORCOV, T. N.; CALY, D. N.; TAJARA, E. H.; GOLONI-BERTOLLO, E. M.; CARVALHO, A. L.; et al. Validation of methylation markers for diagnosis of oral cavity cancer. EUROPEAN JOURNAL OF CANCER, v. 51, n. 5, p. 632-641, MAR 2015. (10/51168-0, 11/02864-7)

LEONCINI, EMANUELE; VUKOVIC, VLADIMIR; CADONI, GABRIELLA; GIRALDI, LUCA; PASTORINO, ROBERTA; ARZANI, DARIO; PETRELLI, LIVIA; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA NATASHA; MOYSES, RAQUEL AYUB; et al. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. EUROPEAN JOURNAL OF EPIDEMIOLOGY, v. 33, n. 12, p. 1205-1218, DEC 2018. (10/51168-0, 04/12054-9)

SEVERINO, PATRICIA; OLIVEIRA, LILIANE SANTANA; TORRES, NATALIA; ANDREGHETTO, FLAVIA MAZIERO; GUARIZO KLINGBEIL, MARIA DE FATIMA; MOYSES, RAQUEL; WUENSCH-FILHO, VICTOR; NUNES, FABIO DAUMAS; MATHOR, MONICA BEATRIZ; PASCHOAL, ALEXANDRE ROSSI; et al. High-throughput sequencing of small RNA transcriptomes reveals critical biological features targeted by microRNAs in cell models used for squamous cell cancer research. BMC Genomics, v. 14, OCT 26 2013. (10/51168-0, 09/04166-5)

SEVERINO, PATRICIA; OLIVEIRA, LILIANE SANTANA; ANDREGHETTO, FLAVIA MAZIERO; TORRES, NATALIA; CURIONI, OTAVIO; CURY, PATRICIA MALUF; TOPORCOV, TATIANA NATASHA; PASCHOAL, ALEXANDRE ROSSI; DURHAM, ALAN MITCHELL. Small RNAs in metastatic and non-metastatic oral squamous cell carcinoma. BMC MEDICAL GENOMICS, v. 8, JUN 24 2015. (10/51168-0)

DA CUNHA, BIANCA RODRIGUES; DOMINGOS, CELIA; BUZZO STEFANINI, ANA CAROLINA; HENRIQUE, TIAGO; POLACHINI, GIOVANA MUSSI; CASTELO-BRANCO, PEDRO; TAJARA, ELOIZA HELENA. Cellular Interactions in the Tumor Microenvironment: The Role of Secretome. JOURNAL OF CANCER, v. 10, n. 19, p. 4574-4587, 2019. (13/03839-1, 12/06048-2, 10/51168-0)

DI CREDICO, GIOIA; EDEFONTI, VALERIA; POLESEL, JERRY; PAULI, FRANCESCO; TORELLI, NICOLA; SERRAINO, DIEGO; NEGRI, EVA; LUCE, DANIELE; STUCKER, ISABELLE; MATSUO, KEITARO; et al. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncology, v. 94, p. 47-57, JUL 2019. (10/51168-0, 04/12054-9)

LIU, HONGLIANG; LI, GUOJUN; STURGIS, ERICH M.; SHETE, SANJAY; DAHLSTROM, KRISTINA R.; DU, MULONG; AMOS, CHRISTOPHER, I; CHRISTIANI, DAVID C.; LAZARUS, PHILIP; WEI, QINGYI. Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck. International Journal of Cancer, v. 151, n. 4, p. 12-pg., 2022-05-07. (04/12054-9, 10/51168-0)

GIRALDI, L.; LEONCINI, E.; PASTORINO, R.; WUNSCH-FILHO, V.; DE CARVALHO, M.; LOPEZ, R.; CADONI, G.; ARZANI, D.; PETRELLI, L.; MATSUO, K.; et al. Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Annals of Oncology, v. 28, n. 11, p. 2843-2851, NOV 2017. (10/51168-0, 04/12054-9)

ANANTHARAMAN, DEVASENA; ABEDI-ARDEKANI, BEHNOUSH; BEACHLER, DANIEL C.; GHEIT, TARIK; OLSHAN, ANDREW F.; WISNIEWSKI, KATHY; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; TAJARA, ELOIZA H.; LEVI, JOSE EDUARDO; et al. Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer. International Journal of Cancer, v. 140, n. 9, p. 8-pg., 2017-05-01. (04/12054-9, 10/51168-0)

KACHURI, LINDA; SAARELA, OLLI; BOJESEN, STIG EGIL; SMITH, GEORGE DAVEY; LIU, GEOFFREY; LANDI, MARIA TERESA; CAPORASO, NEIL E.; CHRISTIANI, DAVID C.; JOHANSSON, MATTIAS; PANICO, SALVATORE; et al. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. International Journal of Epidemiology, v. 48, n. 3, p. 751-766, JUN 2019. (10/51168-0, 04/12054-9)

SILVA, ELISANGELA DE PAULA; MARTI, LUCIANA CAVALHEIRO; ANDREGHETTO, FLAVIA MAZIERO; DE SALES, ROMARIO OLIVEIRA; HOBERMAN, MARTIN; DIAS, BARBARA DOS SANTOS; ALVES DINIZ, LARISSA FIGUEIREDO; DOS SANTOS, ALESSANDRO MARINS; MOYSES, RAQUEL AJUB; CURIONI, OTAVIO ALBERTO; et al. Extracellular vesicles cargo from head and neck cancer cell lines disrupt dendritic cells function and match plasma microRNAs. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 17 2021. (10/51168-0)

CHANG, CHUN-PIN; CHANG, SHEN-CHIH; CHUANG, SHU-CHUN; BERTHILLER, JULIEN; FERRO, GILLES; MATSUO, KEITARO; WUNSCH-FILHO, VICTOR; TOPORCOV, TATIANA N.; DE CARVALHO, MARCOS BRASILINO; LA VECCHIA, CARLO; et al. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). CANCER EPIDEMIOLOGY, v. 63, DEC 2019. (10/51168-0)

ARCHANJO, ANDERSON BARROS; EVANGELISTA MONTEIRO DE ASSIS, ARICIA LEONE; DE OLIVEIRA, MAYARA MOTA; MENDES, SUZANNY OLIVEIRA; BORCOI, ALINE RIBEIRO; MAIA, LUCAS DE LIMA; DE SOUZA, RAFAEL PEREIRA; DE CICCO, RAFAEL; SAITO, KELLY CRISTINA; KIMURA, EDNA TERUKO; et al. Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival. SCIENTIFIC REPORTS, v. 10, n. 1, JUN 25 2020. (04/12054-9, 10/51168-0)

BRAVI, FRANCESCA; LEE, YUAN-CHIN AMY; HASHIBE, MIA; BOFFETTA, PAOLO; CONWAY, DAVID I.; FERRARONI, MONICA; LA VECCHIA, CARLO; EDEFONTI, VALERIA; INVESTIGATORS, INHANCE CONSORTIUM. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. ORAL DISEASES, v. 27, n. 1, JUL 2020. (10/51168-0, 04/12054-9)

PERDOMO, SANDRA; ANANTHARAMAN, DEVASENA; FOLL, MATTHIEU; ABEDI-ARDEKANI, BEHNOUSH; DURAND, GEOFFROY; ROSA, LUCIANA ALBINA REIS; HOLMILA, REETTA; LE CALVEZ-KELM, FLORENCE; TAJARA, ELOIZA H.; WUNSCH-FILHO, VICTOR; et al. Genomic analysis of head and neck cancer cases from two high incidence regions. PLoS One, v. 13, n. 1, JAN 29 2018. (10/51168-0, 04/12054-9)

BERTHILLER, JULIEN; STRAIF, KURT; AGUDO, ANTONIO; AHRENS, WOLFGANG; DOS SANTOS, ALEXANDRE BEZERRA; BOCCIA, STEFANIA; CADONI, GABRIELLA; CANOVA, CRISTINA; CASTELLSAGUE, XAVIER; CHEN, CHU; et al. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis. International Journal of Epidemiology, v. 45, n. 3, p. 835-845, JUN 2016. (10/51168-0)

LESSEUR, CORINA; DIERGAARDE, BRENDA; OLSHAN, ANDREW F.; WUNSCH-FILHO, VICTOR; NESS, ANDREW R.; LIU, GEOFFREY; LACKO, MARTIN; ELUF-NETO, JOSE; FRANCESCHI, SILVIA; LAGIOU, PAGONA; et al. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nature Genetics, v. 48, n. 12, p. 1544-1550, DEC 2016. (10/51168-0, 04/12054-9)

TOPORCOV, TATIANA NATASHA; ZNAOR, ARIANA; ZHANG, ZUO-FENG; YU, GUO-PEI; WINN, DEBORAH M.; WEI, QINGYI; VILENSKY, MARTA; VAUGHAN, THOMAS; THOMSON, PETER; TALAMINI, RENATO; et al. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. International Journal of Epidemiology, v. 44, n. 1, p. 169-185, FEB 2015. (10/51168-0, 04/12054-9)

SHETE, SANJAY; LIU, HONGLIANG; WANG, JIAN; YU, ROBERT; STURGIS, ERICH M.; LI, GUOJUN; DAHLSTROM, KRISTINA R.; LIU, ZHENSHENG; AMOS, CHRISTOPHER I.; WEI, QINGYI. A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck. Cancer Research, v. 80, n. 12, p. 2451-2460, JUN 15 2020. (04/12054-9, 10/51168-0)

GORMLEY, MARK; YARMOLINSKY, JAMES; DUDDING, TOM; BURROWS, KIMBERLEY; MARTIN, RICHARD M.; THOMAS, STEVEN; TYRRELL, JESSICA; BRENNAN, PAUL; PRING, MIRANDA; BOCCIA, STEFANIA; et al. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study. PLOS GENETICS, v. 17, n. 4, APR 2021. (10/51168-0)

POLACHINI, GIOVANA MUSSI; DE CASTRO, TIALFI BERGAMIN; SMARRA, LUIS FABIANO SOARES; HENRIQUE, TIAGO; DE PAULA, CARLOS HENRIQUE DINIZ; SEVERINO, PATRICIA; LOPEZ, ROSSANA VERONICA MENDOZA; CARVALHO, ANDRE LOPES; DE MATTOS ZERI, ANA CAROLINA; SILVA, ISMAEL DALE COTRIM GUERREIRO; et al. Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction. SCIENTIFIC REPORTS, v. 13, n. 1, p. 21-pg., 2023-05-26. (19/07293-0, 21/07087-0, 21/03647-1, 11/23353-0, 10/51168-0)

LESSEUR, CORINA; FERREIRO-IGLESIAS, AIDA; MCKAY, JAMES D.; BOSSE, YOHAN; JOHANSSON, MATTIAS; GABORIEAU, VALERIE; LANDI, MARIA TERESA; CHRISTIANI, DAVID C.; CAPORASO, NEIL C.; BOJESEN, STIG E.; et al. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers. PLOS GENETICS, v. 17, n. 3, MAR 2021. (10/51168-0, 04/12054-9)

STEFANINI, ANA CAROLINA B.; DA CUNHA, BIANCA RODRIGUES; HENRIQUE, TIAGO; TAJARA, ELOIZA H.. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. DISEASE MARKERS, v. 2015, p. 17-pg., 2015-01-01. (10/51168-0)

HENRIQUE, TIAGO; FREITAS DA SILVEIRA, NELSON JOSE; CUNHA VOLPATO, ARTHUR HENRIQUE; MIOTO, MAYRA MATARUCO; BUZZO STEFANINI, ANA CAROLINA; FARES, ADIL BACHIR; DA SILVA CASTRO ANDRADE, JOAO GUSTAVO; MASSON, CAROLINA; MENDOZA LOPEZ, ROSSANA VERONICA; NUNES, FABIO DAUMAS; et al. u HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, v. N/A, p. 11-pg., 2016-03-24. (10/51168-0)

GOYAL, NEERAV; HENNESSY, MAX; LEHMAN, ERIK; LIN, WENXUE; AGUDO, ANTONIO; AHRENS, WOLFGANG; BOCCIA, STEFANIA; BRENNAN, PAUL; BRENNER, HERMANN; CADONI, GABRIELLA; et al. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium. ORAL DISEASES, v. N/A, p. 14-pg., 2022-04-08. (04/12054-9, 10/51168-0)