Assessment of iron status in rats fed high-fat diets

• Grant number: 10/05644-5
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2010
• End date: November 30, 2012
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Célia Colli
• Grantee: Célia Colli
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Alexandre Rodrigues Lobo ; Jorge Mancini Filho ; Lilian Rose Marques de Sá ; Patrícia Gama ; Primavera Borelli Garcia

Abstract

Obesity, is considered as a multifactorial syndrome, influenced by genetic and environmental factors. It is characterized by the expansion of the adipose tissue as a result of a positive energy imbalance. The increase in adiposity may promote a low-intensity chronic inflammatory scenario, which is involved in the etiology of peripheral insulin resistance, thus contributing to increase the cardiovascular risk. The relation between the increase in adiposity and alterations in Fe status was raised from the knowledge about how the genes involved in Fe homeostasis worked. The present project intends to investigate the eventual alterations in Fe homeostasis and its repercussions on the bioavailability of the mineral in a model of obesity in rats fed high-fat diets(comprising a mixture of soybean oil and swine fat [lard]) in different levels, over 60 days. Pair feeding groups will be utilized to correct the amount of energy consumed by the high-fat groups in comparison to the control group (normal level of lipids in the diet). Fe status, assessed through biochemical and gene expression parameters, as well as through the lipid profile and both inflammation and insulin resistance markers, will be analyzed after 15, 30 and 60 days of experimentation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CARLI, EDUARDO; LOBO, ALEXANDRE R.; SALES, CRISTIANE H.; TEIXEIRA, PRYSCILA D. S.; SALES, ANA LINA DE CARVALHO C.; COLLI, CELIA. Short-term dietary magnesium restriction lowers spleen iron concentrations in growing rats fed a high-fat diet. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 59, n. 2, 2, SI, p. 1298-1303, DEC 2014. (09/05624-7, 11/08895-1, 10/05644-5)

DE CARLI, EDUARDO; LOBO, ALEXANDRE R.; SALES, CRISTIANE H.; TEIXEIRA, PRYSCILA D. S.; SALES, ANA LINA DE CARVALHO C.; COLLI, CELIA. Short-term dietary magnesium restriction lowers spleen iron concentrations in growing rats fed a high-fat diet. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 59, n. 2, p. 6-pg., 2014-12-01. (11/08895-1, 09/05624-7, 10/05644-5)

LOBO, ALEXANDRE R.; GAIEVSKI, EDUARDO H. S.; DE MESQUITA, CARLOS HENRIQUE; DE CARLI, EDUARDO; TEIXEIRA, PRYSCILA DRYELLE S.; PEREIRA, ROSA M. R.; BORELLI, PRIMAVERA; DE SA, LILIAN R. M.; COLLI, CELIA. Increased adiposity by feeding growing rats a high-fat diet results in iron decompartmentalisation. BRITISH JOURNAL OF NUTRITION, v. 123, n. 10, p. 1094-1108, MAY 28 2020. (10/05644-5)