Acquisition of a high-performance platform for computational analyses applied to the field of medicine

• Grant number: 09/53853-5
• Support Opportunities: Multi-user Equipment Program
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Wilson Araújo da Silva Junior
• Grantee: Wilson Araújo da Silva Junior
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• EMU web page: Página do Equipamento Multiusuário não informada
• Type of equipment: Tipo de Equipamento Multiusuário não informado
• Manufacturer: Fabricante não informado
• Model: Modelo não informado

Abstract

The proposal is aimed at the acquisition and setup of a high-performance platform for computational analyses applied to the field of medicine, with an emphasis on genomics. The availability of various state-of-the-art models of sequencers has resulted in a great volume of raw data. However, data processing capacities have not kept pace with that increase and therefore represent a stumbling block to the computational analysis of the data generated. The groups involved in this proposal have extensive experience with sequencing data, being (and having been) directly involved in various projects in the area of genomics. The data processing power of genomics platforms has also been used in various analyses, including drug design and the modeling of biological systems. The platform requested here will also benefit projects in these areas of knowledge. We expect this platform to have a significant impact on the projects carried out by the groups involved. The proposal also encompasses the organization of two courses on the processing and analysis of genomic data, which will be open to all interested parties within the scientific community. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KROLL, JOSE EDUARDO; GALANTE, PEDRO A. F.; OHARA, DANIEL T.; NAVARRO, FABIO C. P.; OHNO-MACHADO, LUCILA; DE SOUZA, SANDRO J.. A new portal for the analysis of human splicing variants. RNA BIOLOGY, v. 9, n. 11, p. 1339-1343, NOV 2012. (09/53853-5)

QUINTERO, MELISSA; ADAMOSKI, DOUGLAS; DOS REIS, LARISSA MENEZES; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; SOUSA DE OLIVEIRA, KRISHINA RATNA; GONCALVES, KALIANDRA DE ALMEIDA; DIAS, MARILIA MEIRA; CARAZZOLLE, MARCELO FALSARELLA; GOMES DIAS, SANDRA MARTHA. Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer. BMC CANCER, v. 17, NOV 7 2017. (14/17820-3, 15/25832-4, 14/18061-9, 12/09452-9, 12/11577-4, 09/53853-5, 13/23510-4, 14/06512-6, 14/15968-3)

ARAUJO, L. F.; TERRA, JR., A. T.; SARES, C. T. G.; SOBREIRA, C. F. R.; FARIA, E. F.; MACHADO, R. D.; RODRIGUES, JR., A. A.; MUGLIA, V. F.; SILVA, JR., W. A.; REIS, R. B.. Mitochondrial genome analysis in penile carcinoma. MOLECULAR BIOLOGY REPORTS, v. 45, n. 4, p. 591-600, AUG 2018. (13/08135-2, 09/53853-5, 13/25119-0)

MUYS, BRUNA RODRIGUES; SOUSA, JOSANE F.; PLACA, JESSICA RODRIGUES; DE ARAUJO, LUIZA FERREIRA; SARSHAD, AISHE A.; ANASTASAKIS, DIMITRIOS G.; WANG, XIANTAO; LI, XIAO LING; DE MOLFETTA, GREICE ANDREOTTI; RAMAO, ANELISA; et al. miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism. Cancer Research, v. 79, n. 13, p. 3294-3305, JUL 1 2019. (16/22307-9, 13/08135-2, 09/53853-5, 13/25119-0, 13/25326-6)

BARROS, ISABELA I.; LEAO, VITOR; SANTIS, JESSICA O.; ROSA, REGINALDO C. A.; BROTTO, DANIELLE B.; STORTI, CAMILA B.; SIENA, ADAMO D. D.; MOLFETTA, GREICE A.; SILVA, JR., WILSON A.. Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective. NON-CODING RNA, v. 7, n. 1, MAR 2021. (09/53853-5, 13/08135-2)

ARAUJO, LUIZA FERREIRA; MOLFETTA, GREICE ANDREOTTI; VINCENZI, OTAVIO COSTA; HUBER, JAIR; TEIXEIRA, LORENA ALVES; FERRAZ, VICTOR EVANGELISTA; SILVA JR, WILSON ARAUJO. Molecular basis of familial adenomatous polyposis in the southeast of Brazil: identification of six novel mutations. International Journal of Biological Markers, v. 34, n. 1, p. 80-89, MAR 2019. (13/08135-2, 09/53853-5, 11/11456-0, 13/25119-0)

ARAUJO, L. F.; SIENA, A. D. D.; PLACA, J. R.; BROTTO, D. B.; BARROS, I. I.; MUYS, B. R.; BIAGI JR, C. A. O.; PERONNI, K. C.; SOUSA, J. F.; MOLFETTA, G. A.; et al. Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma. SCIENTIFIC REPORTS, v. 8, SEP 21 2018. (18/04017-9, 13/08135-2, 09/53853-5, 15/21940-7, 13/25119-0)

BATISTA, FERNANDA A. H.; TRIVELLA, DANIELA B. B.; BERNARDES, AMANDA; GRATIERI, JOYCE; OLIVEIRA, PAULO S. L.; FIGUEIRA, ANA CAROLINA M.; WEBB, PAUL; POLIKARPOV, IGOR. Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding. PLoS One, v. 7, n. 5, MAY 11 2012. (06/00182-8, 09/53853-5, 10/17048-8)