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Microbiological and endotoxins analysis in primarily infected root canals with apical periodontitis and their antigenic potencial against macrophages to produce IL1-beta e TNF-alfa during endodontic treatment

Grant number: 10/19136-1
Support Opportunities:Regular Research Grants
Start date: July 01, 2011
End date: November 30, 2013
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Brenda Paula Figueiredo de Almeida Gomes
Grantee:Brenda Paula Figueiredo de Almeida Gomes
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINHO, FREDERICO C.; CHIESA, WANDERSON M. M.; LEITE, FABIO R. M.; CIRELLI, JONI A.; GOMES, BRENDA P. F. A.. Correlation between Clinical/Radiographic Features and Inflammatory Cytokine Networks Produced by Macrophages Stimulated with Endodontic Content. JOURNAL OF ENDODONTICS, v. 38, n. 6, p. 740-745, . (10/17877-4, 10/19136-1)
GOMES, BRENDA P. F. A.; ENDO, MARCOS S.; MARTINHO, FREDERICO C.. Comparison of Endotoxin Levels Found in Primary and Secondary Endodontic Infections. JOURNAL OF ENDODONTICS, v. 38, n. 8, p. 1082-1086, . (10/17877-4, 10/19136-1)
SOUSA, EZILMARA L. R.; MARTINHO, FREDERICO C.; LEITE, FABIO R. M.; NASCIMENTO, GUSTAVO G.; GOMES, BRENDA P. F. A.. Macrophage Cell Activation with Acute Apical Abscess Contents Determined by Interleukin-1 Beta and Tumor Necrosis Factor Alpha Production. JOURNAL OF ENDODONTICS, v. 40, n. 11, p. 1752-1757, . (10/19136-1, 10/17877-4, 11/09047-4)
FREDERICO C. MARTINHO; FÁBIO R. M. LEITE; LETÍCIA M.M. NÓBREGA; MARCOS S. ENDO; GUSTAVO G. NASCIMENTO; RICHARD P. DARVEAU; BRENDA P. F. A. GOMES. Comparison of Fusobacterium nucleatum and Porphyromonas gingivalis Lipopolysaccharides Clinically Isolated from Root Canal Infection in the Induction of Pro-Inflammatory Cytokines Secretion. Brazilian Dental Journal, v. 27, n. 2, p. 202-207, . (10/17877-4, 10/19136-1, 11/09047-4)
SALUSTIANO MARINHO, ARIANE CASSIA; MARTINHO, FREDERICO CANATO; ZAIA, ALEXANDRE AUGUSTO; RANDI FERRAZ, CAIO CEZAR; FIGUEIREDO DE ALMEIDA GOMES, BRENDA PAULA. Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. Journal of Applied Oral Science, v. 22, n. 6, p. 490-495, . (13/02402-9, 10/17877-4, 10/19136-1, 11/09047-4, 10/13743-3)
MARINHO, ARIANE C. S.; POLAY, ANA R. O.; GOMES, BRENDA P. F. A.. Accuracy of Turbidimetric Limulus Amebocyte Lysate Assay for the Recovery of Endotoxin Interacted with Commonly Used Antimicrobial Agents of Endodontic Therapy. JOURNAL OF ENDODONTICS, v. 41, n. 10, p. 1653-1659, . (10/19136-1, 13/02402-9, 10/17877-4)
HERRERA, D. R.; SILVA, E. J. N. L.; SANTOS, C. C.; ZAIA, A. A.; FERRAZ, C. C. R.; ALMEIDA, J. F. A.; GOMES, B. P. F. A.. Root canal content from primary endodontic infection and upregulation of gelatinases in fibroblast cells. International Endodontic Journal, v. 48, n. 12, p. 1168-1174, . (10/19136-1, 10/17877-4, 10/13498-9)
MARINHO, ARIANE C. S.; MARTINHO, FREDERIC C.; LEITE, FABIO R. M.; NASCIMENTO, GUSTAVO G.; GOMES, BRENDA P. F. A.. Proinflammatory Activity of Primarily Infected Endodontic Content against Macrophages after Different Phases of the Root Canal Therapy. JOURNAL OF ENDODONTICS, v. 41, n. 6, p. 817-823, . (10/19136-1, 13/02402-9, 10/17877-4)
ARIANE CASSIA SALUSTIANO MARINHO; FREDERICO CANATO MARTINHO; ALEXANDRE AUGUSTO ZAIA; CAIO CEZAR RANDI FERRAZ; BRENDA PAULA FIGUEIREDO DE ALMEIDA GOMES. Influence of the apical enlargement size on the endotoxin level reduction of dental root canals. Journal of Applied Oral Science, v. 20, n. 6, p. 661-666, . (10/17877-4, 10/19136-1)
MARTINHO, FREDERIC C.; LEITE, FABIO R. M.; CHIESA, WANDERSON M. M.; NASCIMENTO, GUSTAVO G.; FERES, MAGDA; GOMES, BRENDA P. F. A.. Signaling Pathways Activation by Primary Endodontic Infectious Contents and Production of Inflammatory Mediators. JOURNAL OF ENDODONTICS, v. 40, n. 4, p. 484-489, . (10/19136-1, 13/02402-9, 10/17877-4)
MARINHO, A. C. S.; MARTINHO, F. C.; GONCALVES, L. M.; RABANG, H. R. C.; GOMES, B. P. F. A.. Does the Reciproc file remove root canal bacteria and endotoxins as effectively as multifile rotary systems?. International Endodontic Journal, v. 48, n. 6, p. 542-548, . (13/02402-9, 10/13498-9, 10/17877-4, 13/17928-6, 10/19136-1, 11/09047-4)
ENDO, M. S.; MARTINHO, F. C.; ZAIA, A. A.; FERRAZ, C. C. R.; ALMEIDA, J. F. A.; GOMES, B. P. F. A.. Quantification of cultivable bacteria and endotoxin in post-treatment apical periodontitis before and after chemo-mechanical preparation. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, v. 31, n. 10, p. 2575-2583, . (10/17877-4, 10/19136-1)