Advanced search
Start date
Betweenand

Dynamics of visceral leishmaniasis in populations submitted to different control measures

Abstract

Leishmaniasis is a disease of worldwide distribution and represents a serious public health problem. The natural hosts are foxes, opossums and domestic dog (considered the main reservoir of the disease). The etiologic agent of visceral leishmaniasis is Leishmania chagasi in Americas. The transmission of leishmaniasis occurs primarily by the bite of an infected insect vector. Current control strategies recommended by the Ministry of Health in Brazil are: a) early diagnosis and proper treatment of human cases; b) use of insecticides with residual action and domestic ; c) sanitary measures to reduce the vector density; d) identification and elimination of domestic reservoir. Immunoprophylaxis and use of collars impregnated with deltamethrin in dogs and mosquito nets impregnated with insecticide are also important measures to be followed. Due to the difficulty of controlling this disease, cost and complexity of protocols, it is necessary a re-evaluation of effectiveness and feasibility of these protocols in theoretical studies, such as the use of mathematical modeling. The existing models to assess the dynamics of visceral leishmaniasis consider only dogs as transmitters of the parasite to the vectors in the disease cycle, unlike the model of Burattini and colleagues, that considers man as involved on disease cycle. This model was only used to simulate the elimination of the intermediate host (dogs) and reduction of the vector population. This study aims to evaluate the evolution of visceral leishmaniasis dynamics with the use of collar and vaccine in dogs from endemic areas in Brazil, using as a base the Burattini model and colleagues. The evolution of the disease will be simulated according to the parameters related to the hosts and vector measured in Panorama, São Paulo - Brazil. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SEVA, ANAIA P.; OVALLOS, FREDY G.; AMAKU, MARCUS; CARRILLO, EUGENIA; MORENO, JAVIER; GALATI, EUNICE A. B.; LOPES, ESTELA G.; SOARES, RODRIGO M.; FERREIRA, FERNANDO. Canine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Brazil. PLoS One, v. 11, n. 7, . (12/01442-4)
SEVA, ANAIA DA PAIXAO; FERREIRA, FERNANDO; AMAKU, MARCOS. How much does it cost to prevent and control visceral leishmaniasis in Brazil? Comparing different measures in dogs. PLoS One, v. 15, n. 7, . (12/01442-4)