| Grant number: | 12/01442-4 |
| Support Opportunities: | Regular Research Grants |
| Start date: | June 01, 2012 |
| End date: | May 31, 2014 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine |
| Principal Investigator: | Fernando Ferreira |
| Grantee: | Fernando Ferreira |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated researchers: | Eunice Aparecida Bianchi Galati ; José Soares Ferreira Neto ; Marcos Amaku ; Ricardo Augusto Dias ; Rodrigo Martins Soares |
Abstract
Leishmaniasis is a disease of worldwide distribution and represents a serious public health problem. The natural hosts are foxes, opossums and domestic dog (considered the main reservoir of the disease). The etiologic agent of visceral leishmaniasis is Leishmania chagasi in Americas. The transmission of leishmaniasis occurs primarily by the bite of an infected insect vector. Current control strategies recommended by the Ministry of Health in Brazil are: a) early diagnosis and proper treatment of human cases; b) use of insecticides with residual action and domestic ; c) sanitary measures to reduce the vector density; d) identification and elimination of domestic reservoir. Immunoprophylaxis and use of collars impregnated with deltamethrin in dogs and mosquito nets impregnated with insecticide are also important measures to be followed. Due to the difficulty of controlling this disease, cost and complexity of protocols, it is necessary a re-evaluation of effectiveness and feasibility of these protocols in theoretical studies, such as the use of mathematical modeling. The existing models to assess the dynamics of visceral leishmaniasis consider only dogs as transmitters of the parasite to the vectors in the disease cycle, unlike the model of Burattini and colleagues, that considers man as involved on disease cycle. This model was only used to simulate the elimination of the intermediate host (dogs) and reduction of the vector population. This study aims to evaluate the evolution of visceral leishmaniasis dynamics with the use of collar and vaccine in dogs from endemic areas in Brazil, using as a base the Burattini model and colleagues. The evolution of the disease will be simulated according to the parameters related to the hosts and vector measured in Panorama, São Paulo - Brazil. (AU)
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