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Comparative study of composition of biomolecules of Bothrops jararaca venom snake milked and processed in the Herpetology Laboratory of Instituto Butantan between 1963 and 2009


Belonging to the Viperidae family, the genus Bothrops has more than 30 species and subspecies of snakes distributed between Central America and South America members of this genus are important from a clinical standpoint, accounting for approximately 70% of snakebites in Brazil.The study of snake venoms is an important area of biomedical research, primarily because of their pathophysiological actions, such as neurotoxic, hemorrhagic, coagulant and tissue damage.Concerning the Bothrops venom, there are mainly three pathophysiologic activities: proteolytic, best defined as acute inflammatory, coagulant and hemorrhagic.The elucidation of these activities is important both for research related to poisons, as for the production of antiophidic sera, considering that, if present, the variations can result in the production of sera less effective and inconsistent results in scientific research. In this context, there is no enough information for standardization and stabilization of the different components of snake venoms.There is a clear need for the use of poisons references to national as well as the standardization of testing methods of the biological activities of snake venoms in Brazil to ensure uniformity in ophidian sera. Thus, the Butantan Institute became responsible for the preparation and distribution of poisons, both for the preparation of ophidian sera, and for use in research.In this context, considering the importance of obtaining poisons whose properties are preserved and well determined, and the lack of information about the stability of poisons with respect to collection time, we intend to study the longevity of biological activities and biochemical characteristics of the venom of Bothrops jararaca extracted at the Laboratory of Herpetology of the Instituto Butantan since the 1960s. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HATAKEYAMA, DANIELA M. `; DE MORAIS-ZANI, KAREN; SERINO-SILVA, CAROLINE; GREGO, KATHLEEN F.; SANT'ANNA, SAVIO S.; FERNANDES, WILSON; ANIZ, PATRICIA A. E. A.; TORQUATO, RICARDO J. S.; TANAKA, APARECIDA S.; SANZ, LIBIA; et al. Examination of biochemical and biological activities of Bothrops jararaca (Serpentes: Viperidae; Wied-Neuwied 1824) snake venom after up to 54 years of storage. Toxicon, v. 141, p. 34-42, . (12/10266-5, 14/11108-0, 13/00267-7, 12/12997-7, 14/50510-8, 13/05357-4)

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