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Biomarkers in Alzheimer's Disease and mild cognitive impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers

Grant number: 11/17092-0
Support type:Research Grants - Young Investigators Grants
Duration: April 01, 2013 - March 31, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Marcio Luiz Figueredo Balthazar
Grantee:Marcio Luiz Figueredo Balthazar
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Benito Pereira Damasceno ; Carlos Otávio Brandão ; Felipe Paulo Guazzi Bergo ; Fernando Cendes ; Leonilda Maria Barbosa dos Santos
Associated grant(s):18/15571-7 - Mapping the progression of subjective cognitive decline to mild cognitive impairment and Alzheimer´s disease dementia with multimodal biomarkers, AP.JP2
Associated scholarship(s):14/25429-2 - Association between lobar microbleeds, CSF amyloid-beta, and epsilon-4 APOE allele in patients with dementia due to Alzheimer's Disease and mild cognitive impairment, BP.IC
14/02359-9 - Amnestic mild cognitive impairment with increased risk factor for Alzheimer's Disease: effect of cardiorespiratory training on clinical parameters and functional and structural neuroimaging, BP.DR
13/25857-1 - Relationship between different physiopathological processes in Alzheimer's Disease and amnestic mild cognitive impairment: the roles of inflammation, beta-amyloid, tau protein and APOE4 gene, BP.IC
13/10431-9 - Anatomical and functional connectivity in Default Mode and Salience Networks in mild dementia of Alzheimer's Disease and amnestic mild cognitive impairment, BP.DD
12/19128-4 - Biomarkers in Alzheimer's Disease and mild cognitive impairment: evaluation of functional magnetic resonance imaging methods, plasmatic and cerebrospinal fluid markers, BP.JP

Abstract

Alzheimer's disease (AD) is among the most prevalent clinical conditions, mostly due to the population ageing. Also, among the most prevalent diseases, AD is the only which does not have effective prevention and treatment. One of the most relevant aspects in AD research is the development of biomarkers to characterize this disease in its earlier stage, aiming a better pharmacological management with current and future drugs. The new diagnostic criteria of AD (NIA-Alzheimer's Association 2011) include the use of biomarkers, which makes this study essential in our country. In this project, our main objectives are: 1) To start a new line in our Institution of translational research in AD, which promotes research into various aspects of the disease. Specifically, the study of pathophysiological mechanisms such as determination of beta-amyloid protein and total tau and phosphorylated tau in cerebrospinal fluid (CSF) and inflammatory markers like interleucine (IL) 1, IL-6, IL-10, IL-12, IL-18, Tumoral Necrosis Factor-alpha, alpha1-antichymotrypsin and TGF² in plasma and CSF. 2) To create ideal conditions for our center to take part actively in the Brazilian version of Alzheimer's Disease Neuroimaging Initiative (ADNI - Brazil), under discussion by the Brazilian Academy of Neurology. Specifically, we will study techniques for functional and structural neuroimaging. The functional MRI is a method with high potential to become an image biomarker, by using the method without cognitive tasks (intrinsic functional connectivity), which can identify the integrity of certain neurofunctional networks. We aim to correlate this method with structural neuroimaging (volumetry, voxel-based morphometry, tractography, cortical thickness). All these data will be evaluated in conjunction with cognitive, neuropsychiatric and functional aspects. This project features a new line of research in our Institution and may contribute significantly to the creation of a national network of neuroimaging in dementia, like ADNI, which exists in the U.S., Europe and Japan. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
THAÍS T. HAYATA; FELIPE P. G. BERGO; THIAGO J. REZENDE; ALFREDO DAMASCENO; BENITO P. DAMASCENO; FERNANDO CENDES; FLORINDO STELLA; MARCIO L. F. BALTHAZAR. Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease. Arquivos de Neuro-Psiquiatria, v. 73, n. 7, p. -, Jul. 2015.
HAYATA, THAIS T.; BERGO, FELIPE P. G.; REZENDE, THIAGO J.; DAMASCENO, ALFREDO; DAMASCENO, BENITO P.; CENDES, FERNANDO; STELLA, FLORINDO; BALTHAZAR, MARCIO L. F. Cortical correlates of affective syndrome in dementia due to Alzheimer's disease. Arquivos de Neuro-Psiquiatria, v. 73, n. 7, p. 553-560, JUL 2015. Web of Science Citations: 5.
WEILER, MARINA; DE CAMPOS, BRUNNO MACHADO; NOGUEIRA, MATEUS HENRIQUE; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F. Structural connectivity of the default mode network and cognition in Alzheimer's disease. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 223, n. 1, p. 15-22, JUL 30 2014. Web of Science Citations: 13.
WEILER, MARINA; FUKUDA, AYA; MASSABKI, LILIAN H. P.; LOPES, TATILA M.; FRANCO, ALEXANDRE R.; DAMASCENO, BENITO P.; CENDES, FERNANDO; BALTHAZAR, MARCIO L. F. Default Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease. Current Alzheimer Research, v. 11, n. 3, p. 274-282, MAR 2014. Web of Science Citations: 18.
FIGUEREDO BALTHAZAR, MARCIO LUIZ; DE CAMPOS, BRUNNO MACHADO; FRANCO, ALEXANDRE ROSA; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO. Whole cortical and default mode network mean functional connectivity as potential biomarkers for mild Alzheimer's disease. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 221, n. 1, p. 37-42, JAN 30 2014. Web of Science Citations: 27.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.