Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation

• Grant number: 12/20141-5
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2013
• End date: January 31, 2015
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Kátia de Angelis Lobo D Avila
• Grantee: Kátia de Angelis Lobo D Avila
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brazil
• Associated researchers: Christiane Malfitano ; Iris Callado Sanches

Abstract

After the menopause there is an increased incidence of hypertension, insulin resistance, type 2 diabetes and morbidity and mortality. On the other hand, the aerobic exercise has been recommended as an important therapy for the prevention and treatment of cardiometabolic disorders, consedering the recognized benefits of this approach in different populations. More recently, resistance exercise training has been recommended in guidelines for cardiovascular and metabolic diseases, however, little is known about the physiological benefits of this approach. Moreover, there are few studies investigating the mechanisms involved in the potential benefits of dynamic aerobic, resistance or combined (aerobic + resistance) exercise training after ovarian hormone deprivation, especially in the presence of cardiometabolic disorders. Thus, the purpose of this study is to evaluate and compare the effects of dynamic aerobic, resistance or combined exercise training in normotensive diabetic ovariectomized rats and in hypertensive ovariectomized rats submitted to a high fructose diet. Four subprojects (SP) will be conducted to investigate parameters of cardiovascular function (blood pressure, blood pressure, and heart rate, HR), cardiovascular autonomic control (HR and BP variability and baroreflex sensitivity), metabolic (body and adipose tissue weight, blood glucose and triglycerides, insulin tolerance) and physical capacity (maximal test and treadmill running test maximum load on ladder), and its relationship to changes in oxidative stress parameters (lipid peroxidation by chemiluninescence, redox balance by oxidized glutathione / reduced glutathione, carbonylated proteins, superoxide anion and hydrogen peroxide, catalase, glutathione peroxidase, superoxide dismutase, total antioxidant capacity), nitric oxide metabolism (plasma nitrite and nitrate concentration) and inflammation (leptin, adiponectin, TNF alpha, IL-6 and IL-10). Female Wistar rats will be evaluated in SP1: euglycemic (CS), streptozotocin (STZ) diabetic (DS), euglycemic ovariectomized (OS) and diabetic ovariectomized (ODS). In the SP2, female diabetic ovariectomized rats will be divided into: sedentary (ODS) or subjected to physical training on a treadmill (ODA), on ladder (ODR) or subjected to physical training combined ladder and treadmill every other day (ODC). The SP3 will evaluated Wistar controls (CS), and spontaneously hypertensive rats (SHR) divided into:sedentary (HS), sedentary ovariecomized (OHS) and sedentary ovariecomized (OHS) submitted to fructose overload (OHFS). In SP4, female SHR ovariectomized rats treated chronically with fructose will be divided into: sedentary (OHFS) or subjected to aerobic (OHFA), resistance (OHFR) or combined (OHFC) exercise training. The results of this study can contribute to a better understanding of the mechanisms involved in the association of risk factors in women, as well as to the knowledge regarding the effects of aerobic, resistance or combined exercise training in animal models involving ovarian hormones deprivation and glycemic control dysfunctions in presence of normotension (STZ diabetes) or hypertension (SHR treated with fructose). (AU)

Scientific publications

(19)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONTI, FILIPE FERNANDES; BRITO, JANAINA DE OLIVEIRA; BERNARDES, NATHALIA; DIAS, DANIELLE DA SILVA; SANCHES, IRIS CALLADO; MALFITANO, CHRISTIANE; FRANCISCA LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause. BMC CARDIOVASCULAR DISORDERS, v. 14, DEC 11 2014. (12/20141-5, 10/17188-4, 11/15828-9)

FILIPE FERNANDES CONTI; IRIS CALLADO SANCHES; NATHALIA BERNARDES; GUILHERME LEMOS SHIMOJO; DIEGO MENDROT TABOAS FIGUEROA; ROGÉRIO BRANDÃO WICHI; KÁTIA DE ANGELIS. Influência dos hormônios sexuais no consumo de oxigênio de ratos. Revista Brasileira de Medicina do Esporte, v. 20, n. 6, p. 421-423, 2014-12-00. (12/20141-5, 11/16441-0)

QUINTEIRO, HUGO; BUZIN, MORGANA; CONTI, FILIPE FERNANDES; DIAS, DANIELLE DA SILVA; FIGUEROA, DIEGO; LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; SANCHES, IRIS CALLADO; DE ANGELIS, KATIA. Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, v. 22, n. 5, p. 534-541, MAY 2015. (12/20141-5)

SANCHES, IRIS C.; CONTI, FILIPE F.; BERNARDES, NATHALIA; BRITO, JANAINA DE O.; GALDINI, ELIA G.; CAVAGLIERI, CLAUDIA R.; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Impact of combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats. Journal of Applied Physiology, v. 119, n. 6, p. 656-662, SEP 15 2015. (12/20141-5)

DA PALMA, RENATA K.; MORAES-SILVA, IVANA C.; DIAS, DANIELLE DA SILVA; SHIMOJO, GUILHERME L.; CONTI, FILIPE F.; BERNARDES, NATHALIA; BARBOZA, CATARINA A.; SANCHES, IRIS C.; DA ROSA ARAUJO, ALEX SANDER; IRIGOYEN, MARIA-CLAUDIA; et al. Resistance or aerobic training decreases blood pressure and improves cardiovascular autonomic control and oxidative stress in hypertensive menopausal rats. Journal of Applied Physiology, v. 121, n. 4, p. 1032-1038, OCT 1 2016. (12/20141-5, 11/16441-0)

SANCHES, I. C.; CONTI, F. F.; SARTORI, M.; IRIGOYEN, M. C.; DE ANGELIS, K.. Standardization of Resistance Exercise Training: Effects in Diabetic Ovariectomized Rats. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 35, n. 4, p. 323-329, APR 2014. (12/20141-5)

MOSTARDA, CRISTIANO T.; RODRIGUES, BRUNO; DE MORAES, OSCAR ALBUQUERQUE; MORAES-SILVA, IVANA C.; OLINTO ARRUDA, PAULA BARROS; CARDOSO, RUYMAR; SCAPINI, KATIA BILHAR; DOS SANTOS, FERNANDO; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA. Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 28, n. 3, p. 273-278, MAY-JUN 2014. (12/20141-5, 07/58942-0)

FERREIRA FREITAS, SARAH CRISTINA; HARTHMANN, ANGELA D'AVILA; RODRIGUES, BRUNO; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats. DIABETOLOGY & METABOLIC SYNDROME, v. 7, DEC 21 2015. (12/20141-5)

MALFITANO, CHRISTIANE; BARBOZA, CATARINA ANDRADE; MOSTARDA, CRISTIANO; DA PALMA, RENATA KELLY; DOS SANTOS, CAMILA PAIXAO; RODRIGUES, BRUNO; FERREIRA FREITAS, SARAH CRISTINA; BELLO-KLEIN, ADRIANE; LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; et al. Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats. CARDIOVASCULAR DIABETOLOGY, v. 13, OCT 10 2014. (12/20141-5, 14/18685-2)

GOLDMEIER, SILVIA; DE ANGELIS, KATIA; CASALI, KARINA RABELLO; VILODRE, CESAR; CONSOLIM-COLOMBO, FERNANDA; KLEIN, ADRIANE BELLO; PLENTZ, RODRIGO; SPRITZER, POLIMARA; IRIGOYEN, MARIA-CLAUDIA. Cardiovascular autonomic dysfunction in primary ovarian insufficiency: clinical and experimental evidence. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, v. 6, n. 1, p. 91-101, 2014. (12/20141-5)

MOSTARDA, CRISTIANO; RODRIGUES, BRUNO; MEDEIROS, ALESSANDRA; MOREIRA, EDSON D.; MORAES-SILVA, IVANA C.; BRUM, PATRICIA C.; DE ANGELIS, KATIA; IRIGOYEN, MARIA-CLAUDIA. Baroreflex deficiency induces additional impairment of vagal tone, diastolic function and calcium handling proteins after myocardial infarction. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, v. 6, n. 3, p. 320-328, 2014. (12/20141-5, 07/58942-0)

BRITO-MONZANI, JANAINA DE O.; SANCHES, IRIS CALLADO; BERNARDES, NATHALIA; PONCIANO, KATIA; MORAES-SILVA, IVANA C.; IRIGOYEN, MARIA-CLAUDIA; LLESUY, SUSANA; DE ANGELIS, KATIA. Hypertension induces additional cardiometabolic impairments and attenuates aerobic exercise training adaptations in fructose-fed ovariectomized rats. HYPERTENSION RESEARCH, v. 41, n. 2, p. 88-95, FEB 2018. (12/20141-5, 10/17188-4, 15/11223-6)

SHIMOJO, G. L.; PALMA, R. K.; BRITO, J. O.; SANCHES, I. C.; IRIGOYEN, M. C.; DE ANGELIS, K.. Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats. Brazilian Journal of Medical and Biological Research, v. 48, n. 6, p. 523-527, JUN 2015. (12/20141-5, 11/16441-0, 12/02023-5, 13/07869-2)

CONTI, FILIPE FERNANDES; BRITO, JANAINA DE OLIVEIRA; BERNARDES, NATHALIA; DIAS, DANIELLE DA SILVA; MALFITANO, CHRISTIANE; MORRIS, MARIANA; FRANCISCA LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evaluations. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 309, n. 12, p. R1532-R1539, DEC 15 2015. (12/20141-5, 11/15828-9)

CASTRO, E. F. S.; MOSTARDA, C. T.; RODRIGUES, B.; MORAES-SILVA, I. C.; FERIANI, D. J.; DE ANGELIS, K.; IRIGOYEN, M. C.. Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome. Brazilian Journal of Medical and Biological Research, v. 48, n. 4, p. 332-338, APR 2015. (12/20141-5, 07/58942-0)

BRITO-MONZANI, JANAINA DE OLIVEIRA; STOYELL-CONTI, FILIPE FERNANDES; SHECAIRA, TANIA PLENS; SILVA, MICHEL PABLO DOS SANTOS FERREIRA; DIAS, DANIELLE DA SILVA; BERNARDES, NATHALIA; DE ANGELIS, KATIA. Aerobic or resistance training improves autonomic control of circulation in oophorectomized rats with cardiometabolic dysfunctions: Impact on renal oxidative stress. Experimental Gerontology, v. 145, MAR 2021. (18/17183-4, 12/20141-5, 10/17188-4)

CONTI, FILIPE F.; BRITO, JANAINA O.; DIAS, DANIELLE S.; BERNARDES, NATHALIA; MALFITANO, CHRISTIANE; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Combined Exercise Training Promotes Additional Benefits Than Aerobic or Resistance Training in a Model of Metabolic Syndrome and Menopause. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (10/17188-4, 12/20141-5, 11/15828-9)

MACHI, JACQUELINE FREIRE; DIAS, DANIELLE DA SILVA; FREITAS, SARAH CRISTINA; DE MORAES, OSCAR ALBUQUERQUE; DA SILVA, MAIKON BARBOSA; CRUZ, PAULA LAZARA; MOSTARDA, CRISTIANO; SALEMI, VERA M. C.; MORRIS, MARIANA; DE ANGELIS, KATIA; et al. Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress. CLINICAL INTERVENTIONS IN AGING, v. 11, p. 341-350, 2016. (12/20141-5)

SANCHES, IRIS CALLADO; BUZIN, MORGANA; CONTI, FILIPE FERNANDES; DIAS, DANIELLE DA SILVA; DOS SANTOS, CAMILA PAIXAO; SIRVENTE, RAQUEL; CURY SALEMI, VERA MARIA; LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause. PLoS One, v. 13, n. 9, SEP 7 2018. (12/20141-5)