Cardiorespiratory pattern and awake-sleep state in male and female rats exposed to fluoxetine during prenatal period

• Grant number: 12/19966-0
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2013
• End date: August 31, 2015
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Principal Investigator: Luciane Helena Gargaglioni Batalhão
• Grantee: Luciane Helena Gargaglioni Batalhão
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Serotonin (5-HT) and noradrenaline (NE) are known to play critical roles in neurodevelopment, cardiorespiratory control and sleep-awake state and these roles may be sex-specific. 5-HT is involved in nervous maturational processes even at the fetal stage, being an important modulator of respiratory rhythm. The serotoninergic receptors 5-HT1A and 5-HT2A are found in the respiratory neurons and they play a key role in this process. Additionally, this receptors are related to hypercapnic and hypoxic responses. Early antidepressant exposure that inhibit serotonin re-uptake (SSRI) in male rats results in long-lasting behavioral effects as well as a reduction in expression of the 5-HT synthetic enzyme (tryptophan hydroxylase) in the raphe nuclei and of the 5-HT transporter (SERT) within their cortical efferent fibers. Such exposure to SSRI not only upregulates the 5-HT raphe system, but also downregulates the noradrenergic locus coeruleus (NE-LC) system since 5-HT inhibits LC function. Therefore, the goal of the present study is to evaluate the possible long-lasting effects of an exposure to SSRIs during a critical period of the development, prenatal period, on cardiorespiratory control system and sleep-awake state of male and female rats. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARQUES, DANUZIA A.; DE CARVALHO, DEBORA; DA SILVA, GLAUBER S. F.; SZAWKA, RAPHAEL E.; ANSELMO-FRANCI, JANETE A.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Ventilatory, metabolic, and thermal responses to hypercapnia in female rats: effects of estrous cycle, ovariectomy, and hormonal replacement. Journal of Applied Physiology, v. 119, n. 1, p. 61-68, JUL 1 2015. (13/17606-9, 12/19966-0)

DANTONIO, VALTER; BATALHAO, MARCELO E.; FERNANDES, MARCIA H. M. R.; KOMEGAE, EVILIN N.; BUQUI, GABRIELA A.; LOPES, NORBERTO P.; GARGAGLIONI, LUCIANE H.; CARNIO, EVELIN C.; STEINER, ALEXANDRE A.; BICEGO, KENIA C.. Nitric oxide and fever: immune-to-brain signaling vs. thermogenesis in chicks. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 310, n. 10, p. R896-R905, MAY 15 2016. (14/13586-6, 12/19966-0, 13/13386-4, 12/03831-8, 14/50265-3)

VIZIN, R. C. L.; SCARPELLINI, C. DA S.; ISHIKAWA, D. T.; CORREA, G. M.; DE SOUZA, C. O.; GARGAGLIONI, L. H.; CARRETTIERO, D. C.; BICEGO, K. C.; ALMEIDA, M. C.. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. ACTA PHYSIOLOGICA, v. 214, n. 2, p. 275-289, JUN 2015. (12/19966-0, 11/19131-2, 09/11446-4, 12/11836-0, 11/06528-1)

FONSECA, ELISA M.; DIAS, MIRELA B.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia. Respiratory Physiology & Neurobiology, v. 224, n. SI, p. 90-99, APR 2016. (08/57712-4, 12/19966-0)

SILVA, CARLOS A.; VICENTE, MARIANE C.; TENORIO-LOPES, LUANA; SOLIZ, JORGE; GARGAGLIONI, LUCIANE H.. Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats. Respiratory Physiology & Neurobiology, v. 236, p. 11-18, FEB 2017. (12/19966-0)

BIANCARDI, VIVIAN; PATRONE, LUIS GUSTAVO A.; VICENTE, MARIANE C.; MARQUES, DANUZIA A.; BICEGO, KENIA C.; FUNK, GREGORY D.; GARGAGLIONI, LUCIANE H.. Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats. Journal of Applied Physiology, v. 133, n. 2, p. 19-pg., 2022-08-01. (12/19966-0, 20/01702-2, 12/15298-2)

VICENTE, MARIANE C.; DIAS, MIRELA B.; FONSECA, ELISA M.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 468, n. 5, p. 763-774, MAY 2016. (12/19966-0)

MARQUES, DANUZIA A.; DE CARVALHO, DEBORA; DA SILVA, GLAUBER S. F.; SZAWKA, RAPHAEL E.; ANSELMO-FRANCI, JANETE A.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Influence of estrous cycle hormonal fluctuations and gonadal hormones on the ventilatory response to hypoxia in female rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 469, n. 10, p. 1277-1286, OCT 2017. (14/12190-1, 13/17606-9, 16/04276-9, 12/19966-0)

DE CARVALHO, D.; MARQUES, D. A.; BERNUCI, M. P.; LEITE, C. M.; ARAUJO-LOPES, R.; ANSELMO-FRANCI, J.; BICEGO, K. C.; SZAWKA, R. E.; GARGAGLIONI, L. H.. ROLE OF SEX HORMONES IN HYPERCAPNIA-INDUCED ACTIVATION OF THE LOCUS COERULEUS IN FEMALE AND MALE RATS. Neuroscience, v. 313, p. 36-45, JAN 28 2016. (12/19966-0)

FONSECA, ELISA M.; DIAS, MIRELA B.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia. Respiratory Physiology & Neurobiology, v. 224, p. 10-pg., 2016-04-01. (08/57712-4, 12/19966-0)