Advanced search
Start date
Betweenand

An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain

Grant number: 16/08176-9
Support type:Research Grants - Young Investigators Grants
Duration: May 01, 2017 - April 30, 2020
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Carlos Eduardo de Almeida
Grantee:Carlos Eduardo de Almeida
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:André Victor Lucci Freitas ; Anete Pereira de Souza ; Danilo Ciccone Miguel ; Elaine Folly Ramos ; João Aristeu da Rosa ; Myriam Harry ; Patricia Jacqueline Thyssen ; Paulo Sergio D' Andrea
Associated scholarship(s):18/20814-6 - Eco-epidemiological aspects of Chagas Disease and Trypanosoma cruzi genotyping of vectors from chagasic outbreak sites in Rio Grande do Norte, BP.IC
17/21359-8 - Integrated molecular approaches to elucidate the ecological associations of Triatoma brasiliensis: food sources, microbiota and diversity of Trypanosoma cruzi, BP.DR
18/21214-2 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.TT
+ associated scholarships 18/20053-5 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.TT
17/19420-0 - Molecular tracking of Trypanosoma Cruzi from Chagas Disease vectors in an outbreak area in Rio Grande do Norte, Brazil, BP.PD
18/08795-6 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.TT
18/04098-9 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.TT
18/04594-6 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.DD
18/04205-0 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.MS
17/09088-9 - An integrative approach to morphological and molecular diversity of Triatoma brasiliensis, the main Chagas Disease vector in the Brazilian semiarid: elucidating links along the epidemiological chain, BP.JP - associated scholarships

Abstract

In semi-arid areas of Brazil, Triatoma brasiliensis is the most important Chagas disease vector, with potential to elucidate aspects of other elements of eco-epidemiologic chain. Therefore, we will use an integrative method applied to T. brasiliensis specimens collected in sites with records of high domiciliary infestation pressure and chagasic outbreaks in the State of Rio Grande do Norte, Brazil. The re-infestation foci (via population genetics) and demographic aspects of T. brasiliensis populations under control activities (via Approximate Bayesian Computation - ABC) will be elucidated by using DNA extracted from legs of insects via two molecular markers: cytochrome b (cytb) fragments and single-nucleotide polymorphisms (SNPs-ddRAD/3dRAD), combined with the geometric morphometrics by using the heads and wings. By using next-generation sequencing (NGS) we will explore genes associated to domiciliation process by analyzing transcriptomes from antennae and rostrum. The Trypanosoma cruzi genotyping, T. brasiliensis feeding sources and T. cruzi reservoirs will be identifying by using NGS to the blood meal ingested by the insect through metagenomics/metabarcoding. The landscape genetics will be applied by combining morphological and genotypic information via ecological and spatial data, aiming to detect corridors for population dispersion of insects that invade homes. This project counts with an innovative and synergic model-approach to determine the vector genetic structure, the genetic base related to domiciliation process, the parasite lineages, T. cruzi reservoir and factor that make possible the vector dispersion to domiciles. Finally, an integrated analysis of results will be converted to a comprehensive way to be passed to those involved in the vector control. (AU)

Articles published in other media outlets (13 total):
More itemsLess items
Análise genética do 'barbeiro' pode levar a novo modo de prevenção da doença de Chagas 
Análise genética do 'barbeiro' pode levar a novos modos de prevenção da doença de Chagas 
Análise genética do 'barbeiro' pode levar a novos modos de prevenção da doença de Chagas 
Análise genética do 'barbeiro' pode levar a novos modos de prevenção da doença de Chagas 
Análise genética de vetor da doença de Chagas pode levar a novas estratégias de prevenção 
Análise genética do 'barbeiro' pode levar a novos modos de prevenção da doença de Chagas 
Análise genética do 'barbeiro' pode levar a novos modos de prevenção da doença de Chagas 
Análise genética de vetor da doença de Chagas pode levar a novas estratégias de prevenção 
Análise genética de vetor da doença de Chagas pode levar a novas estratégias de prevenção 
Análise genética de vetor de Doença de Chagas pode levar a novas estratégias de prevenção 
Análise genética de vetor da doença de Chagas pode levar a novas estratégias de prevenção 
Análise genética de vetor da doença de Chagas pode levar a novas estratégias de prevenção 
Análise genética de vetor da doença de Chagas pode levar a novas estratégias de prevenção 

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAFLON-TEIXEIRA, NATALIA FARIA; COUTINHO, CAROLINA; GOMES, TAIS FERREIRA; TOMA, HELENA KEIKO; DUARTE, ROSEMERE; BOIA, MARCIO NEVES; CARVALHO-COSTA, FILIPE ANIBAL; ALMEIDA, CARLOS EDUARDO; LIMA, MARLI MARIA. Multiple Approaches to Address Potential Risk Factors of Chagas Disease Transmission in Northeastern Brazil. American Journal of Tropical Medicine and Hygiene, v. 100, n. 2, p. 296-302, 2019. Web of Science Citations: 0.
DALE, CAROLINA; ALMEIDAZ, CARLOS EDUARDO; MENDONCA, VAGNER JOSE; OLIVERIA, JADER; DA ROSA, JOAO ARISTEU; GALVDOS, CLEBER; COSTA, JANE. An updated and illustrated dichotomous key for the Chagas disease vectors of Triatoma brasiliensis species complex and their epidemiologic importance. ZOOKEYS, n. 805, p. 33-43, DEC 11 2018. Web of Science Citations: 0.
OLIVEIRA, JADER; MARCET, PAULA L.; TAKIYA, DANIELA M.; MENDONCA, VAGNER J.; BELINTANI, TIAGO; BARGUES, MARIA D.; MATEO, LUCIA; CHAGAS, VIVIAN; FOLLY-RAMOS, ELAINE; CORDEIRO-ESTRELA, PEDRO; GURGEL-GONCALVES, RODRIGO; COSTA, JANE; DA ROSA, JOAO A.; ALMEIDA, CARLOS E. Combined phylogenetic and morphometric information to delimit and unify the Triatoma brasiliensis species complex and the Brasiliensis subcomplex. Acta Tropica, v. 170, p. 140-148, JUN 2017. Web of Science Citations: 10.
LILIOSO, MAURICIO; FOLLY-RAMOS, ELAINE; ROCHA, FABIANA LOPES; RABINOVICH, JORGE; CAPDEVIELLE-DULAC, CLAIRE; HARRY, MYRIAM; MARCET, PAULA L.; COSTA, JANE; ALMEIDA, CARLOS EDUARDO. High Triatoma brasiliensis Densities and Trypanosoma cruzi Prevalence in Domestic and Peridomestic Habitats in the State of Rio Grande do Norte, Brazil: The Source for Chagas Disease Outbreaks?. American Journal of Tropical Medicine and Hygiene, v. 96, n. 6, p. 1456-1459, 2017. Web of Science Citations: 4.
MARCHANT, AXELLE; MOUGEL, FLORENCE; JACQUIN-JOLY, EMMANUELLE; COSTA, JANE; ALMEIDA, CARLOS EDUARDO; HARRY, MYRIAM. Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis. PLoS Neglected Tropical Diseases, v. 10, n. 10 OCT 2016. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.