| Grant number: | 17/08892-9 |
| Support Opportunities: | Regular Research Grants |
| Start date: | November 01, 2017 |
| End date: | October 31, 2019 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Physical-Chemistry |
| Principal Investigator: | Ana Paula Ramos |
| Grantee: | Ana Paula Ramos |
| Host Institution: | Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
| Associated researchers: | Pietro Ciancaglini |
Abstract
The synthesis of highly-ordered nanostructured materials that offer specific responses when submitted to an external stimulus is one of the application of nanotechnology. The ability to investigate substances at the molecular level started the search for materials with improved properties to medical applications. The use of these molecularly-controlled materials gave rise to a new research field named nanobiotechnology that has focus in the diagnosis, drug-delivery and implantable materials. The surface chemistry, physics, and thermodynamics, as well as toxicological effects drive the specific application of these materials. The interconnection between these set of properties direct the applications. In this context, different surface modifications can give rise to new materials with distinct biological properties and functionalities to a specific final application, for example to enhance the solubility in the physiological media.In the special case of implantable materials, the surface properties become more important once the success of the application lies in the guest tissue/material interfacial contact. In these materials, the initial cell contact never occurs on a clean surface. The contact occurs on a surface coated with water molecules, ions, and proteins adsorved from the blood-plasma. So, the interaction with water molecules, adsorption of proteins, and cell adhesion are the first events that take place at the tissue/implant interface. The conditioned surface will dictate the cell adhesion and behavior.In the present project, bioactive surfaces (surfaces able to induce the formation of hydroxyapatite when in contact with physiological media) will be synthesized and characterized, focusing in the titanium (the metal most used for bone repair) surface modifications with Langmuir-Blodgett films containing lipids, proteins, and sterols. Moreover, metal oxide (TiO2, ZrO2) nanoparticles and biominerals (CaCO3 and apatites) with different geometries, structuraly modified using cations or anions substituion, and suface-modified by osteogenic proteins adsorption will be tested. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |