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Proteomic of auto-inducers from Lactobacillus SP. responsible for bacterial communication in the control of Salmonella Heidelberg in broiler chickens

Grant number: 17/17712-4
Support type:Regular Research Grants
Duration: November 01, 2017 - October 31, 2019
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Adriano Sakai Okamoto
Grantee:Adriano Sakai Okamoto
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers:Elisane Lenita Milbradt ; Fabiana Ferreira de Souza ; Raphael Lucio Andreatti Filho


Foodborne diseases have always been considered a problem not only in the production of food of animal origin, but also in public health. But in recent years mainly due to the demands of international bodies on exported products and end consumers for a quality product, has been the focus of discussions in recent years. Salmonella spp. Is the main and most important agent involved in foodborne diseases. In addition to biosecurity, alternative measures should be implemented for control, such as specific vaccinations in hens and broilers, acquisition of free batches of the agent, use of organic acids and probiotics that aid in inhibiting the growth of Salmonella spp. Probiotics are bacteria that are part of the natural microbiota of birds, for example, Lactobacillus spp. Which induce the balance of the intestinal microbiota favoring several beneficial actions for the host, exerted by the complex and dynamic intestinal microenvironment. One such action is the inhibition of Salmonella spp. by Lactobacillus spp. That among others, a form of inhibition is intra and interspecies communication, termed quorum sensing, where bacteria notice changes in the environment through signaling substances secreted by individual cells and are recognized by specific receptors of another bacterium that leads to modification of bacterial behavior, resulting in a collective response. The objective of this work will be to evaluate the capacity of Lactobacillus spp. isolates from chickens inhibit the growth of Salmonella Heidelberg by the quorum sensing mechanism in vitro and in vivo. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OKAMOTO, ADRIAN SAKAI; ANDREATTI FILHO, RAPHAEL LUCIO; MILBRADT, ELISANE LENITA; IZIDORO MORAES, ANA CAROLINA; BASTOS VELLANO, IGOR HENRIQUE; CHALFUN GUIMARAES-OKAMOTO, PRISCYLLA TATIANA. Bacterial communication between Lactobacillus spp. isolated from poultry in the inhibition of Salmonella Heidelberg-proof of concept. POULTRY SCIENCE, v. 97, n. 8, p. 2708-2712, AUG 2018. Web of Science Citations: 0.

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