Isolation and identification of secondary metabolites with high and medium polarity and analysis of populational variation of Lychnophora granmongolense (Duarte) Semir & Leitão Filho

• Grant number: 08/02304-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2008
• End date: July 31, 2009
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Norberto Peporine Lopes
• Grantee: Leandro de Santis Ferreira
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The family Asteraceae, that had extensive worldwide distribution, is characterized by its ability to produce variety of secondary metabolites, which are often responsible for the therapeutic or toxic effects of the plants. The species Lychnophora granmongolense (Duarte) Semir & Leitao Filho (Vernonieae, Asteraceae), is known for its trypanocidal effect. This specie has a restricted distribution to the brazilian cerrado. The secondary metabolites are currently targets of studies where hipheneted techniques are applied with the purpose of conducting a dereplication of complex mixtures. These techniques can also be extremely useful in the quality control of phytotherapic medicine, mainly in industrial scale, in an attempt to monitor and ensure the consistency of active ingredients and / or markers characteristic of the plant species. Adding to this, it is also important to highlight the ecological importance of phytochemicals studies in trying to understand the interactions of individuals with their habitat and the differences and similarities between the populations of the same species.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERREIRA, Leandro de Santis. Analysis of populational variation and characterization of secondary metabolites in the leaves of Lychnophora granmongolense (Duarte) Semir & Leitão Filho.. 2010. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.