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Role of serotonergic receptors of periaqueductal gray on antinociception of mice confined to open arms the elevated plus-maze

Grant number: 09/17938-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2010
Effective date (End): March 31, 2015
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Azair Liane Matos Do Canto de Souza
Grantee:Daniela Baptista de Souza
Home Institution: Centro de Educação e Ciências Humanas (CECH). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):12/06009-7 - Role of serotoninergic neurotransmission on oxaliplatin-induced neuropathy in mice, BE.EP.DD


The pain is an universal experience, and frequently follows anxiety and depression cases. Some specific drugs used in depression and anxiety treatment are also used for the relief of pain. There are evidences showing that exposure to threatening situations can result in pain inhibition. In this way, studies involving pain and anxiety use animal models as tools for potential therapeutic agents screening as well as for enhance the knowledge about the neurobiology of emotions. This study investigated the following effects: acute and chronic fluoxetine treatment; microinjections of 5-HT1A and 5HT2C receptors agonists intra-periaqueductal gray matter (PAG), and the administration combined of these drugs on antinociception induced by the open arms (OAA) of the elevated plus maze (EPM). Furthermore, we investigated the effects of fluoxetine chronic treatment on serotonin, 5-HIAA, 5-HT1A and 5HT2C receptors levels within PAG. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BAPTISTA-DE-SOUZA, DANIELA; PELARIN, VINICIUS; CANTO-DE-SOUZA, LUCAS; NUNES-DE-SOUZA, RICARDO LUIZ; CANTO-DE-SOUZA, AZAIR. Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice. Neuropharmacology, v. 140, p. 100-106, SEP 15 2018. Web of Science Citations: 1.
RODRIGUES TAVARES, LIGIA RENATA; BAPTISTA-DE-SOUZA, DANIELA; CANTO-DE-SOUZA, AZAIR. Activation of 5-HT2C (but not 5-H-1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-H-2C antagonist or systemic fluoxetine. Neuropharmacology, v. 135, p. 376-385, JUN 2018. Web of Science Citations: 1.
BAPTISTA-DE-SOUZA, DANIELA; NUNCIATO, ANA C.; PEREIRA, BARBARA C.; FACHINNI, GABRIEL; ZANIBONI, CAROLINE R.; CANTO-DE-SOUZA, AZAIR. Mice undergoing neuropathic pain induce anxiogenic-like effects and hypernociception in cagemates. Behavioural Pharmacology, v. 26, n. 7, SI, p. 664-672, OCT 2015. Web of Science Citations: 10.
BAPTISTA, DANIELA; NUNES-DE-SOUZA, RICARDO LUIZ; CANTO-DE-SOUZA, AZAIR. Activation of 5-HT2C receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze. Behavioural Brain Research, v. 235, n. 1, p. 42-47, NOV 1 2012. Web of Science Citations: 8.

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