Assessing the potential antioxidant, cytotoxic and sunscreen of extracts and fractions of Hymenaea courbaril L. and Hymenaea stigonocarpa Mart

• Grant number: 11/15430-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2012
• End date: July 31, 2014
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Regildo Márcio Gonçalves da Silva
• Grantee: Patrícia Aparecida Figueiredo
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Free radicals are atoms or molecules that contain an unpaired electron in the last electronic layer, a fact that makes them unstable and highly reactive. The overproduction of these molecules causes oxidative stress, being extremely harmful to essential biological molecules, which can cause many different diseases, including various forms of cancer. Community leaders of Assis / SP have reported the use of jatoba species for the treatment and prevention of skin cancer and prevent premature aging, possibly due to its antioxidant action. Therefore, this project aims the evaluation of the antioxidant potential by sequestering free radicals through the test of DPPH, ORAC and Effect of Iron Chelation; cytotoxicity in cultured melanoma murine cells (B16F10-Nex2) and sun protection factor through in vitro by the spectrophotometric method. In addition, this project aims to quantify the total phenolics and flavonoids, also to conducting the bioassay-guided fractionation and characterization of phytochemical extracts of Hymenaea courbaril and Hymeneae stigonocarpa. The expected results may contribute to increase knowledge about the species known as Jatoba (H. courbaril and H. stigonocarpa), besides elucidating ethnobotanical reports of its uses as an antioxidant, sunscreen, anti-carcinogenic and anti-cancer, thus providing a possible identification of new pharmacological compounds capable of employment and /or nutrition.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIEL, AMANDA MARTINS; SILVA, LUCIANA PEREIRA; MARTINS, GUSTAVO RAFAGNIN; URTREMARI, BETSAIDA; SEKIYA, ALLINE; DOKKEDAL, ANNE LIGIA; DE SOUZA, EDISLANE BARREIROS; CHERICI CAMARGO, ISABEL CRISTINA; GONCALVES SILVA, REGILDO MARCIO. TOXICOLOGICAL, GENOTOXIC AND ANTIOXIDANT POTENTIAL OF PYROSTEGIA VENUSTA. BIOSCIENCE JOURNAL, v. 35, n. 2, p. 570-585, MAR-APR 2019. (11/15430-5)

KAMILLE D. SPERA; PATRÍCIA A. FIGUEIREDO; PAMELA C.E SANTOS; FERNANDO C. BARBOSA; CAIO P. ALVES; ANNE LÍGIA DOKKEDAL; LUIZ LEONARDO SALDANHA; LUCIANA P. SILVA; CARLOS ROGÉRIO FIGUEIREDO; PAULO CESAR FERREIRA; et al. Genotoxicity, anti-melanoma and antioxidant activities of Hymenaea courbaril L. seed extract. Anais da Academia Brasileira de Ciências, v. 91, n. 4, 2019-12-02. (11/15430-5)

VIEL, AMANDA MARTINS; SILVA, LUCIANA PEREIRA; MARTINS, GUSTAVO RAFAGNIN; URTREMARI, BETSAIDA; SEKIYA, ALLINE; DOKKEDAL, ANNE LIGIA; DE SOUZA, EDISLANE BARREIROS; CHERICI CAMARGO, ISABEL CRISTINA; GONCALVES SILVA, REGILDO MARCIO. TOXICOLOGICAL, GENOTOXIC AND ANTIOXIDANT POTENTIAL OF PYROSTEGIA VENUSTA. BIOSCIENCE JOURNAL, v. 35, n. 2, p. 16-pg., 2019-03-01. (11/15430-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FIGUEIREDO, Patrícia Aparecida. Avaliação do potencial antioxidante, citotóxico e fotoprotetor de extratos de Hymenaea courbaril L. e Hymenaea stigonocarpa Mart. ex Hayne. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Letras. Assis Assis.