| Grant number: | 11/51800-1 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | March 01, 2012 |
| End date: | February 28, 2015 |
| Field of knowledge: | Biological Sciences - Biochemistry - Metabolism and Bioenergetics |
| Principal Investigator: | Roger Frigério Castilho |
| Grantee: | Tiago Rezende Figueira |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract Eccentric exercise-induced muscle damage (EIMD) is the most common muscle trauma associated with exercise. EIMD arises when unaccustomed exercise tasks involving eccentric muscle contractions are performed. EIMD generally leads to: i) delayed onset muscle soreness; ii) loss of joint range of motion; iii) muscle edema; iv) contractile dysfunction; v) muscle inflammation; vi) and a variety of metabolic alterations. These changes evolve from myocyte structural injury (sarcomere disarrangement, cell membrane rupture, etc.) that is imposed by eccentric muscle contractions. It was demonstrated that cellular calcium overload is a primary abnormality in EIMD etiology. Also, EIMD promotes calcium accumulation within mitochondria. It is widely appreciated that mitochondrial calcium overload may lead to opening of mitochondrial permeability transition pore (MPT), which can disrupt mitochondrial integrity and function, promote cell death and tissue damage. Our hypothesis is that calcium-induced MPT plays a role in EIMD and in associated abnormalities such as mitochondrial respiratory depression. Therefore, we aim at investigating whether MPT inhibition by means of pharmacological tools (cyclosporin A, an inhibitor of MPT; Ru360, an inhibitor of mitochondrial calcium uptake) can abrogate EIMD and the associated mitochondrial changes in rats. Additionally, we will approach the known harmful interaction (i.e. higher prevalence of statins side effects) between eccentric exercise and statins, a class of drugs that possess mitochondrial and muscular toxicity. (AU) | |
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