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Effects of beta-alanine supplementation combined or not with sodium bicarbonate on intermittent anaerobic performance

Grant number: 11/17059-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2012
Effective date (End): January 31, 2014
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Antonio Herbert Lancha Junior
Grantee:Guilherme Giannini Artioli
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Evidences indicate that muscle acidosis is one of the major causes of fatigue in high-intensity exercises. A variety of mechanisms regulates muscle pH, including extracellular buffers, intracellular buffers and dynamic buffering (i.e., efflux of H+ ions to outside the cell). Bicarbonate is the most important extracellular system for the immediate control of pH. Recent studies indicate that carnosine, a dipeptide endogenously sinthesized in muscle from the aminoacids L-histidine and ²-alanine, plays a very important role as an intracellular buffer. The rate-limiting point of carnosine synthesis seems to be the availablility of ²-alanine in muscle. Therefore, ²-alanine supplementation is able to significantly increase intramuscular content of carnosine. Studies show that both ²-alanine (which increases an intracellular buffer) and sodium bicarbonate (an extracelular buffer) are capable of improving performance in exercises of short-duration and high-intensity, is special the intermitent exercises. The purpose of the present study is to investigate whether ²-alanine supplementation has additive ergogenic effects to sodium bicarbonate. Secondary objectives are to explore underlying mechanisms that are possibly involved with the effects of supplementation. About 40 male athletes will take part in the study. They will be randomly allocated into one of 4 groups: ²-alanine + NaHCO3, ²-alanine + placebo, NaHCO3 + placebo, placebo + placebo. All athletes will be assessed PRE and POST the supplementation period (4 weeks of ²-alanine; 1 week of sodium bicarbonate). Performance will be evaluated through 4 bouts of the lower-limbs Wingate Test (30 s of duration at 7.7 kp . kg-1 interspersed by a 3-min recovery period). A familiarization session will take place before the beginning of the study. Before (at rest) and immediately after the 4th bout, blood and muscle samples (from vastus lateralis, using the percutaneous biopsy technique) will be collected, processed and further analyzed. It will be determined: blood pH, plasma lactate and bicarbonate, as well as muscle lactate, glycogen, carnosine and total buffering capacity. We will also determine the expression of the ²-alanine transporter, the carnosine synthetase enzyme and the MCT1 and MCT4. The data obtained will be analyzed with mixed-models ANOVA (proc mixed, SAS v. 9.0). (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCHINI, EMERSON; BRITO, CIRO JOSE; FUKUDA, DAVID H.; ARTIOLI, GUILHERME G.. The Physiology of Judo-Specific Training Modalities. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 28, n. 5, p. 1474-1481, . (11/17059-2)
MENDES, SANDRO H.; TRITTO, ALINE C.; GUILHERME, JOAO PAULO L. F.; SOLIS, MARINA Y.; VIEIRA, DOUGLAS E.; FRANCHINI, EMERSON; LANCHA, JR., ANTONIO H.; ARTIOLI, GUILHERME G.. Effect of rapid weight loss on performance in combat sport male athletes: does adaptation to chronic weight cycling play a role?. BRITISH JOURNAL OF SPORTS MEDICINE, v. 47, n. 18, p. 1155+, . (11/17059-2, 12/22516-6)
LOTURCO, IRINEU; ARTIOLI, GUILHERME GIANNINI; KOBAL, RONALDO; GIL, SAULO; FRANCHINI, EMERSON. PREDICTING PUNCHING ACCELERATION FROM SELECTED STRENGTH AND POWER VARIABLES IN ELITE KARATE ATHLETES: A MULTIPLE REGRESSION ANALYSIS. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 28, n. 7, p. 1826-1832, . (11/17059-2)
PASQUA, LEONARDO A.; BUENO, SALOMAO; ARTIOLI, GUILHERME G.; LANCHA, ANTONIO H.; MATSUDA, MONIQUE; MARQUEZINI, MONICA V.; LIMA-SILVA, ADRIANO E.; SALDIVA, PAULO H. N.; BERTUZZI, ROMULO. Influence of ACTN3 R577X polymorphism on ventilatory thresholds related to endurance performance. JOURNAL OF SPORTS SCIENCES, v. 34, n. 2, p. 163-170, . (11/17059-2, 10/13913-6, 12/07319-0)
PAINELLI, VITOR DE SALLES; ROSCHEL, HAMILTON; DE JESUS, FLAVIA; SALE, CRAIG; HARRIS, ROGER CHARLES; SOLIS, MARINA YAZIGI; BENATTI, FABIANA BRAGA; GUALANO, BRUNO; LANCHA, JR., ANTONIO HERBERT; ARTIOLI, GUILHERME GIANNINI. The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 38, n. 5, p. 525-532, . (11/17059-2, 10/11221-0)
PAINELLI, VITOR DE SALLES; DA SILVA, RAFAEL PIRES; DE OLIVEIRA JUNIOR, ODILON MARQUES; DE OLIVEIRA, LUANA FARIAS; BENATTI, FABIANA BRAGA; RABELO, TOBIAS; LIMONGI FRANCA GUILHERME, JOAO PAULO; LANCHA JUNIOR, ANTONIO HERBERT; ARTIOLI, GUILHERME GIANNINI. The Effects of Two Different Doses of Calcium Lactate on Blood pH, Bicarbonate, and Repeated High-Intensity Exercise Performance. INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, v. 24, n. 3, p. 286-295, . (11/17059-2, 10/11221-0, 12/22516-6, 13/04806-0)
TOBIAS, GABRIEL; BENATTI, FABIANA BRAGA; PAINELLI, VITOR DE SALLES; ROSCHEL, HAMILTON; GUALANO, BRUNO; SALE, CRAIG; HARRIS, ROGER C.; LANCHA, JR., ANTONIO HERBERT; ARTIOLI, GUILHERME GIANINNI. Additive effects of beta-alanine and sodium bicarbonate on upper-body intermittent performance. Amino Acids, v. 45, n. 2, p. 309-317, . (11/17059-2, 10/11221-0, 10/12302-3)
LANCHA JUNIOR, ANTONIO HERBERT; PAINELLI, VITOR DE SALLES; SAUNDERS, BRYAN; ARTIOLI, GUILHERME GIANNINI. Nutritional Strategies to Modulate Intracellular and Extracellular Buffering Capacity During High-Intensity Exercise. SPORTS MEDICINE, v. 45, n. 1, p. S71-S81, . (11/17059-2, 14/11948-8, 13/04806-0, 10/11221-0)
FRANCHINI, EMERSON; ARTIOLI, GUILHERME GIANNINI; BRITO, CIRO JOSE. Judo combat: time-motion analysis and physiology. INTERNATIONAL JOURNAL OF PERFORMANCE ANALYSIS IN SPORT, v. 13, n. 3, p. 624-641, . (11/17059-2)

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