Gastroprotective, antioxidant and antidiarreic activity of the ethanolic extracts of Myrcia bella and Bauhinia holophylla

• Grant number: 12/05323-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2012
• End date: May 31, 2013
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Claudia Helena Pellizzon
• Grantee: Daniela Aparecida Silveira Cesar
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The aim of this work is to characterize the gastroprotective, antioxidant and antidiarreic activity of the ethanolic extracts of the plants Myrcia bella and Bauhinia holophylla. We will develop experimental assays using male wistar rats. The ethanol-induced gastric ulcer model will be used to evaluate the gastroprotective effect and choose the lower effective dose of both extracts between the three doses tested 50, 100, 150 mg/kg). The stomachs obtained in this model will be destined to histological and immunohistochemical analyses and to antioxidant assays (SOD and MPO enzymes). The involvement of sulfhydryl compounds, nitric oxide, potassium channels and alfa2 receptors in the gastroprotection will be analysed. The antidiarreic and intestinal motility of the extracts will be also investigated. All results will be statiscally analized by ANOVA followed by Dunnett test with minimum significance of p 0.05

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROZZA, A. L.; CESAR, D. A. S.; PIERONI, L. G.; SALDANHA, L. L.; DOKKEDAL, A. L.; DE-FARIA, F. M.; SOUZA-BRITO, A. R. M.; VILEGAS, W.; TAKAHIRA, R. K.; PELLIZZON, C. H.. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-based Complementary and Alternative Medicine, 2015. (12/05323-0, 09/52237-9)

ROZZA, A. L.; CESAR, D. A. S.; PIERONI, L. G.; SALDANHA, L. L.; DOKKEDAL, A. L.; DE-FARIA, F. M.; SOUZA-BRITO, A. R. M.; VILEGAS, W.; TAKAHIRA, R. K.; PELLIZZON, C. H.. Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract. Evidence-based Complementary and Alternative Medicine, v. 2015, p. 9-pg., 2015-01-01. (09/52237-9, 12/05323-0)