SIZE-TUNED POLYMERIC NANOPARTICLES WITH POTENTIAL APPLICATION IN THE CONTROLLED RELEASE OF CHEMOTHERAPEUTIC AGENTS

• Grant number: 12/17841-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2012
• End date: May 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Fernando Carlos Giacomelli
• Grantee: Anderson Marques de Oliveira
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

The proposed project aims the manufacturing of macromolecular nanostructures with potential application in the nanomedicine. Polymeric Nanoparticles will be produced from a library of biodegradable and biocompatible polyesters and copolyesters by using the nanoprecipitation protocol. The experimental conditions will be investigated towards the production of size-tuned nanostructures with potential application in the drug delivery of antitumoral agents via the EPR (Enhanced Permeation and Retention) effect, where dimensions below the cut-off size of ~ 200 nm is a prerequisite. Subsequently, the emphasis will move to the groundbreaking topic of nanobiointerfaces. The investigations will be devoted to the nature of interaction between nanoscale structures and biological environments, especially on the kinetics and thermodynamics of adsorption of proteins onto the surface of nanoparticle and the resulting protein-nanoparticle complexes. The formation of protein-nanoparticle complexes has critical implications in the biodistribution, biocompatibility and biorecognition of nanostructures by the living matter.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, ANDERSON M.; JAEGER, ELIEZER; JAEGER, ALESSANDRO; STEPANEK, PETR; GIACOMELLI, FERNANDO C.. Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 436, p. 1092-1102, SEP 5 2013. (12/14087-8, 12/17841-5)