Evaluation of hydrodynamic conditions, shear and oxygen transfer of different models in pneumatic bioreactors

• Grant number: 12/17756-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2013
• End date: February 29, 2016
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Alberto Colli Badino Junior
• Grantee: Caroline Eliza Mendes
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The pneumatic reactors have been widely employed in various sectors of the chemical industry, especially where it is required high rates of heat transfer and mass, rapid mixing and appropriate shear rates, such as the cultivation of sensitive cells (fungi and bacteria), so as to produce bioactive compounds by these microorganisms. Thus, in order to evaluate the efficiency or predict the scaling of these reactors, it is of utmost importance the detailed study of the hydrodynamics, mass transfer and shear of this equipment, since these parameters describe its behavior at different operating conditions and working fluids. However, the few studies that analyze how much parameters and especially the few reports of study for this type shear reactor for different operating conditions have led to the preparation of this work, initially aimed at the evaluation of hydrodynamic conditions, shear and mass transfer in bioreactors bubble column, airlift draft tube and airlift split cylinder, ranges from differents scales (5 and 10 L), against different Newtonian and non-Newtonian fluids. Subsequently, in a secondary stage of this projetct, it is proposed to carry out cultivation for a given microorganism test aimed to produce a biocompound from this, using the reactors studied in order to evaluate their behavior and efficiency in relation to the chosen bioprocess. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENDES, CAROLINE E.; BADINO, ALBERTO C.. Oxygen transfer in different pneumatic bioreactors containing viscous Newtonian fluids. CHEMICAL ENGINEERING RESEARCH & DESIGN, v. 94, p. 456-465, FEB 2015. (11/23807-1, 12/17756-8)

MESTRE, JULIA C.; CERRI, MARCEL O.; ESPERANCA, MATEUS N.; PEDROLLI, DANIELLE B.; BADINO, ALBERTO C.. Aeration step method for k(L)a measurement under growth conditions in pneumatic bioreactors. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, v. 94, n. 7, p. 2327-2332, JUL 2019. (11/23807-1, 18/11405-5, 12/17756-8)

ESPERANCA, MATEUS N.; MENDES, CAROLINE E.; RODRIGUEZ, GUILHERME Y.; CERRI, MARCEL O.; BETTEGA, RODRIGO; BADINO, ALBERTO C.. Sparger design as key parameter to define shear conditions in pneumatic bioreactors. Biochemical Engineering Journal, v. 157, APR 15 2020. (11/23807-1, 12/17756-8)

MENDES, CAROLINE E.; BADINO, ALBERTO C.. Hydrodynamics of Newtonian and non-Newtonian liquids in internal-loop airlift reactors. Biochemical Engineering Journal, v. 109, p. 137-152, MAY 15 2016. (11/23807-1, 12/17756-8)

ESPERANCA, MATEUS N.; BUFFO, MARIANE M.; MENDES, CAROLINE E.; RODRIGUEZ, GUILHERME Y.; BETTEGA, RODRIGO; BADINO, ALBERTO C.; CERRI, MARCEL O.. inking maximal shear rate and energy dissipation/circulation function in airlift bioreactor. Biochemical Engineering Journal, v. 178, JAN 2022. (18/11405-5, 20/08699-7, 11/23807-1, 12/17756-8)

ESPERANCA, MATEUS N.; MENDES, CAROLINE E.; RODRIGUEZ, GUILHERME Y.; CERRI, MARCEL O.; BETTEGA, RODRIGO; BADINO, ALBERTO C.. Average shear rate in airlift bioreactors: searching for the true value. Bioprocess and Biosystems Engineering, v. 42, n. 6, p. 995-1008, JUN 2019. (11/23807-1, 12/17756-8)

RODRIGUEZ, G. Y.; VALVERDE-RAMIREZ, M.; MENDES, C. E.; BETTEGA, R.; BADINO, A. C.. Global performance parameters for different pneumatic bioreactors operating with water and glycerol solution: experimental data and CFD simulation. Bioprocess and Biosystems Engineering, v. 38, n. 11, p. 2063-2075, NOV 2015. (11/23807-1, 12/17756-8)

ESPERANCA, MATEUS N.; CERRI, MARCEL O.; MAZZIERO, VITOR T.; BETTEGA, RODRIGO; BADINO, ALBERTO C.. Hydrodynamic comparison of different geometries of square cross-section airlift bioreactor using computational fluid dynamics. INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING, v. N/A, p. 13-pg., 2023-07-07. (12/17756-8, 11/23807-1, 20/08699-7)