It would be scientifically permissible abandon the use of a drug without being exhausted all resources available for its evaluation, as a compound useful for producing anesthesia in a variety of applications? It seems to be the case of thiopental, which has been abandoned instead of propofol, from the beginning of its clinical use, even in the last century, mid of 70th years. Recent studies have shown that the barbiturate induces a higher respiratory stability and better hemogasometry values, as compared to propofol in dogs with pulmonary hypertension. On the other hand, the effect of thiopental in leporina species (Oryctolagus cuniculus) are not known in depth.Thus, this study will assess comparatively thiopental and propofol in rabbits subjected to spontaneous breathing, in order to evaluate many different parameters, to establish reliable values for the species under test and determine the feasibility of replacing propofol by thiopental, over a range of experimental, or not, procedures in leporina species.
News published in Agência FAPESP Newsletter about the scholarship: