Characterization of the role of dendritic cells in the recrudescence of malaria in pregnancy

• Grant number: 13/00981-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2013
• End date: July 31, 2018
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Cláudio Romero Farias Marinho
• Grantee: Oscar Javier Murillo Gómez
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria, AP.JP

Abstract

Each year at least 50 million pregnant women are exposed to Plasmodium. Malaria during pregnancy (MiP, the English "Malaria in Pregnancy") is characterized by the sequestration of parasites in the placenta, and consequent maternal anemia, intrauterine growth retardation and decreased fetal viability. Frequently is observed a recrudescence of the infection during pregnancy, suggesting a complex pathogenic mechanism linked to an imbalance of the immune response. Despite the great advances made in the understanding of immunological aspects of the disease and its relation to pregnancy, the mechanisms involved in protection, especially those needed to maintain a balance between the beneficial and harmful immune response there still remain unclear. Recent evidence suggests the importance of dendritic cells (DCs) in regulating the immune response during infection of pregnant. This form, this project has the final objective the understanding the role of these cells in the resurgence of malaria in pregnancy. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOZA, RENATO; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; MURILLO, OSCAR JAVIER; MACHADO PEIXOTO, ERIKA PAULA; BANDEIRA, CARLA LETICIA; FOTORAN, WESLEY LUZETTI; SARDINHA, LUIS ROBERTO; WUNDERLICH, GERHARD; BEVILACQUA, ESTELA; et al. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. SCIENTIFIC REPORTS, v. 7, AUG 17 2017. (12/16525-2, 11/17880-8, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 11/19048-8, 13/16417-8, 09/53889-0)

REIS, ARAMYS S.; BARBOZA, RENATO; MURILLO, OSCAR; BARATEIRO, ANDRE; PEIXOTO, ERIKA P. M.; LIMA, FLAVIA A.; GOMES, VINICIUS M.; DOMBROWSKI, JAMILLE G.; LEAL, VINICIUS N. C.; ARAUJO, FRANCIELE; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. SCIENCE ADVANCES, v. 6, n. 10, MAR 2020. (14/09964-5, 15/23395-6, 14/20451-0, 17/03939-7, 11/19048-8, 17/05782-8, 13/16417-8, 16/07030-0, 12/16525-2, 12/04755-3, 15/50650-7, 18/20468-0, 13/00981-1, 11/17880-8, 15/06106-0)

DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; et al. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5, MAY 2019. (14/17766-9, 18/20468-0, 12/04755-3, 13/21728-2, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 16/08204-2, 13/16417-8, 09/53889-0)

ORTOLAN, LUANA DOS SANTOS; SERCUNDES, MICHELLE KLEIN; MOURA, GABRIEL CANDIDO; QUIRINO, THATYANE DE CASTRO; DEBONE, DANIELA; COSTA, DOUGLAS DE SOUSA; MURILLO, OSCAR; FARIAS MARINHO, CLAUDIO ROMERO; EPIPHANIO, SABRINA. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, DEC 4 2019. (14/20451-0, 13/20718-3, 13/00981-1, 17/05782-8, 17/00077-4)

LIMA, FLAVIA AFONSO; BARATEIRO, ANDRE; DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; COSTA, DOUGLAS DE SOUSA; MURILLO, OSCAR; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Plasmodium falciparum infection dysregulates placental autophagy. PLoS One, v. 14, n. 12, DEC 5 2019. (17/03939-7, 17/05782-8, 13/16417-8, 12/04755-3, 16/07030-0, 15/06106-0, 13/00981-1, 18/20468-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GÓMEZ, Oscar Javier Murillo. The Characterization of the Role of Dendritic Cells in the Recrudescence Of Malaria in Pregnancy.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.