Prognostic value of the oscillatory pattern of muscle sympathetic nerve activity in patients with heart failure

• Grant number: 13/07651-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2013
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Maria Urbana Pinto Brandão Rondon
• Grantee: Edgar Toschi Dias
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment, AP.TEM
• Associated scholarship(s): 15/17642-0 - A multisystem pathophysiological approach to heart failure with preserved ejection fraction in the elderly: searching for new therapeutic strategies, BE.EP.PD

Abstract

Heart failure (HF) is a complex syndrome, considered as the leading cause of hospitalization in patients over the age of 60 years, and accounts for about 30 to 40% of mortality in patients with severe HF. It is also known that the neurohumoral excitation is a hallmark of HF and independent predictor of mortality in patients suffering from this syndrome. The sympathetic nervous system influence on the cardiovascular control depends on not only its tone, but also its modulation. Thus, both the frequency and the intensity of the sympathetic nerve discharge determine a pattern of oscillation that influences the efficiency of sympathetic effector response. This modulation of sympathetic nerve activity may be evaluated by the balance between the spectral components of low and high frequency of sympathetic nerve activity and represents the intrinsic behavior of the sympathetic nervous system functioning. It has been suggested that the lack of sympathetic modulation in a low frequency band predisposes patients with HF to higher mortality over a period of 12 months follow-up. However, the prognostic value of the oscillatory pattern of muscle sympathetic nerve activity (MSNA) in patients with HF is unknown. The proposal of this study is to test the hypothesis that patients with HF with reduced oscillatory pattern of MSNA present impaired survival and higher rates of hospitalization for a period of clinical follow-up of 12 months when compared with patients with higher oscillatory pattern of MSNA.

Scientific publications

(17)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DUTRA-MARQUES, AKOTHIRENE C.; RODRIGUES, SARA; CEPEDA, FELIPE X.; TOSCHI-DIAS, EDGAR; RONDON, EDUARDO; CARVALHO, JEFFERSON C.; ALVES, MARIA JANIEIRE N. N.; BRAGA, ANA MARIA F. W.; RONDON, MARIA URBANA P. B.; TROMBETTA, IVANI C.. Exaggerated Exercise Blood Pressure as a Marker of Baroreflex Dysfunction in Normotensive Metabolic Syndrome Patients. FRONTIERS IN NEUROSCIENCE, v. 15, JUN 9 2021. (16/16831-7, 11/17533-6, 15/03274-0, 13/07651-7)

TOSCHI-DIAS, EDGAR; TOBALDINI, ELEONORA; SOLBIATI, MONICA; COSTANTINO, GIORGIO; SANLORENZO, ROBERTO; DORIA, STEFANIA; IRTELLI, FLORIANA; MENCACCI, CLAUDIO; MONTANO, NICOLA. Sudarshan Kriya Yoga improves cardiac autonomic control in patients with anxiety-depression disorders. Journal of Affective Disorders, v. 214, p. 74-80, MAY 2017. (15/17642-0, 13/07651-7)

SUFFRITTI, C.; TOBALDINI, E.; SCHIAVON, R.; STRADA, S.; MAGGIONI, L.; MEHTA, S.; SANDRONE, G.; TOSCHI-DIAS, E.; CICARDI, M.; MONTANO, N.. Complement and contact system activation in acute congestive heart failure patients. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v. 190, n. 2, p. 251-257, NOV 2017. (15/17642-0, 13/07651-7)

LOBO, DENISE M. L.; TREVIZAN, PATRICIA F.; TOSCHI-DIAS, EDGAR; OLIVEIRA, PATRICIA A.; PIVETA, RAFAEL B.; ALMEIDA, DIRCEU R.; MADY, CHARLES; BOCCHI, EDIMAR A.; LORENZI-FILHO, GERALDO; MIDDLEKAUFF, HOLLY R.; et al. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure. Circulation-Heart Failure, v. 9, n. 11, NOV 2016. (10/50048-1, 13/07651-7)

GROEHS, RAPHAELA V.; TOSCHI-DIAS, EDGAR; ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; ALVES, MARIA J. N. N.; ALMEIDA, DIRCEU R.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E.. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 9, p. H1096-H1102, MAY 1 2015. (10/50048-1, 13/15651-7, 13/07651-7)

MAKI-NUNES, CRISTIANE; TOSCHI-DIAS, EDGAR; CEPEDA, FELIPE X.; RONDON, MARIA URBANA P. B.; ALVES, MARIA-JANIEIRE N. N.; FRAGA, RAFFAEL F.; BRAGA, ANA MARIA F. W.; AGUILAR, ADRIANA M.; AMARO, ALINE C.; DRAGER, LUCIANO F.; et al. Diet and exercise improve chemoreflex sensitivity in patients with metabolic syndrome and obstructive sleep apnea. OBESITY, v. 23, n. 8, p. 1582-1590, AUG 2015. (08/03714-6, 11/17533-6, 12/02953-2, 13/07651-7)

TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; et al. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, MAR 2019. (08/03714-6, 12/02953-2, 16/16831-7, 13/07651-7, 11/17533-6, 10/50048-1)

TOBALDINI, ELEONORA; TOSCHI-DIAS, EDGAR; TRIMARCHI, PIETRO DAVIDE; BRENA, NICOLA; COMANDUCCI, ANGELA; CASAROTTO, SILVIA; MONTANO, NICOLA; DEVALLE, GUYA. Cardiac autonomic responses to nociceptive stimuli in patients with chronic disorders of consciousness. CLINICAL NEUROPHYSIOLOGY, v. 129, n. 5, p. 1083-1089, MAY 2018. (15/17642-0, 13/07651-7)

TOSCHI-DIAS, EDGAR; MONTANO, NICOLA; TOBALDINI, ELEONORA; TREVIZAN, PATRICIA F.; GROEHS, V, RAPHAELA; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; LOBO, DENISE M.; SALES, ALLAN R. K.; UENO-PARDI, LINDA M.; et al. Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction. FRONTIERS IN NEUROSCIENCE, v. 15, AUG 31 2021. (10/50048-1, 15/17642-0, 13/07651-7, 15/22814-5)

MARCELO R. DOS SANTOS; ANA L.C. SAYEGH; RAFAEL ARMANI; VALÉRIA COSTA-HONG; FRANCIS R. DE SOUZA; EDGAR TOSCHI-DIAS; LUIZ A. BORTOLOTTO; MAURICIO YONAMINE; CARLOS E. NEGRÃO; MARIA-JANIEIRE N.N. ALVES. Resting spontaneous baroreflex sensitivity and cardiac autonomic control in anabolic androgenic steroid users. Clinics, v. 73, 2018-05-21. (12/10527-3, 13/07651-7)

CEPEDA, FELIPE X.; VIRMONDES, LESLIE; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; TOSCHI-DIAS, EDGAR; FERREIRA-CAMARGO, FERNANDA C.; HUSSID, MARIA FERNANDA; RONDON, MARIA URBANA P. B.; ALVES, MARIA JANIEIRE N. N.; TROMBETTA, IVANI C.. Identifying the risk of obstructive sleep apnea in metabolic syndrome patients: Diagnostic accuracy of the Berlin Questionnaire. PLoS One, v. 14, n. 5, MAY 21 2019. (15/03274-0, 16/16831-7, 11/17533-6, 13/15323-0, 13/07651-7)

TOSCHI-DIAS, EDGAR; RONDON, MARIA URBANA P. B.; COGLIATI, CHIARA; PAOLOCCI, NAZARENO; TOBALDINI, ELEONORA; MONTANO, NICOLA. Contribution of Autonomic Reflexes to the Hyperadrenergic State in Heart Failure. FRONTIERS IN NEUROSCIENCE, v. 11, MAR 30 2017. (15/17642-0, 13/07651-7)

RODRIGUES, SARA; CEPEDA, FELIPE X.; TOSCHI-DIAS, EDGAR; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; COSTA-HONG, VALERIA; ALVES, MARIA JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; BORTOLOTTO, LUIZ A.; TROMBETTA, IVANI C.. The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome. JOURNAL OF CLINICAL HYPERTENSION, v. 19, n. 9, p. 840-847, SEP 2017. (11/17533-6, 15/03274-0, 13/15323-0, 13/07651-7)

GROEHS, RAPHAELA V.; NEGRAO, MARCELO V.; HAJJAR, LUDHMILA A.; JORDAO, CAMILA P.; CARVALHO, BRUNA P.; TOSCHI-DIAS, EDGAR; ANDRADE, ANA C.; HODAS, FABIANA P.; ALVES, MARIA J. N. N.; SARMENTO, ADRIANA O.; et al. Adjuvant Treatment with5-Fluorouraciland Oxaliplatin Does Not Influence Cardiac Function, Neurovascular Control, and Physical Capacity in Patients with Colon Cancer. ONCOLOGIST, v. 25, n. 12, AUG 2020. (13/07651-7, 15/22814-5, 15/05427-8, 15/17642-0)

CARVALHO, JEFFERSON CABRAL; CEPEDA, FELIPE XEREZ; RODRIGUES, SARA; BRISOLLA DUTRA-MARQUES, AKOTHIRENE CRISTHINA; TOSCHI-DIAS, EDGAR; PINTO BRANDAO RONDON, MARIA URBANA; NUNES ALVES, MARIA-JANIEIRE NAZARE; FONSECA WANDERLEY BRAGA, ANA MARIA; LORENZI-FILHO, GERALD; TROMBETTA, IVANI CREDIDIO. Oxygen uptake efficiency slope in patients with metabolic syndrome and obstructive sleep apnea. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/07651-7, 15/03274-0, 11/17533-6, 13/15323-0)

CEPEDA, FELIPE XEREZ; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON CABRAL; TOSCHI-DIAS, EDGAR; JORDAO, CAMILA PAIXAO; RONDON, MARIA URBANA; ALVES, MARIA JANIEIRE N. N.; LORENZI-FILHO, GERALDO; TROMBETTA, IVANI CREDIDIO. Obstructive sleep apnea impairs insulin resistance in metabolic syndrome patients with normal levels of glucose. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/07651-7, 15/03274-0, 11/17533-6, 13/15323-0)

VICENTE, WANDA RAFAELA; RODRIGUES, SARA; DUTRA-MARQUES, AKOTHIRENE C. B.; CARVALHO, JEFFERSON C.; JORDAO, CAMILA P.; TOSCHI-DIAS, EDGAR; HUSSID, MARIA FERNANDA; COSTA-HONG, VALERIA; BORTOLOTTO, LUIZ A.; CEPEDA, FELIPE X.; et al. Clustering and combining pattern of metabolic syndrome risk factors and its association with arterial stiffness. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (13/07651-7, 15/03274-0, 11/17533-6, 13/15323-0)