Multifunctional organic-inorganic hybrids siloxane-polyether used as drug delivery systems

• Grant number: 13/02613-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2013
• End date: August 31, 2014
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Eduardo Ferreira Molina
• Grantee: Beatriz Bernardes Caravieri
• Host Institution: Reitoria. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

The ability to shape materials from organic compounds, inorganic, bioactive and even in one direction is interesting to develop new multifunctional hybrid materials. In these hybrids, the association of the characteristics of organic and inorganic compounds allows for new materials with unique properties such as high mechanical strength, transparency and flexibility and is suitable for application in various fields of science and technology, including human health.This project proposes the use of hybrid class siloxane-polyether systems used for controlled drug delivery. These hybrids are prepared by sol-gel and are based on a network of silica containing an organic subphase which can provide both hydrophobic and hydrophilic domains. Moreover, they are water insoluble and have unique properties such as mechanical strength, transparency and flexibility as well as being a material of great potential for various scientific and technological fields. The main objective is to evaluate the effect of incorporation of a model drug (ibuprofen or sodium diclofenac) with hybrid matrix-based polyether (polyoxopropylene PPO) and thus study the transport mechanism involved in the process of drug release.I this context, various concentrations of drug are incorporated into the matrix.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARAVIERI, BEATRIZ B.; DE OLIVEIRA, POLLYANNA F.; FURTADO, RICARDO A.; TAVARES, DENISE C.; NASSAR, EDUARDO J.; CIUFFI, KATIA J.; MOLINA, EDUARDO F.. Solubility enhancement of ibuprofen using tri-ureasil-PPO hybrid: structural, cytotoxic, and drug release investigation. Journal of Sol-Gel Science and Technology, v. 72, n. 3, p. 627-636, DEC 2014. (13/02613-0)