Characterization and quantification of monoalkyl carbonates in aqueous medium employing microfluidic devices coupled to a mass spectrometer

• Grant number: 13/14993-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2013
• End date: May 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Claudimir Lucio Do Lago
• Grantee: Vagner Bezerra dos Santos
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The formation of monoalkyl carbonates (MACs) from carbon dioxide or bicarbonate and alcohols in aqueous medium has been shown in recent works. Among these MACs, those ones from aliphatic alcohols and sugars have been of particular interest. Many metabolites may be included in one of these classes, or they have part of their molecular structure whose reactivity is governed by such groups. Thus, there is an ongoing project (FAPESP 2012/06642-1) about the formation and the properties of MACs with possible biological roles. This new application intends to complement that study by enrolling a new researcher in the group, which will be the head of the development of microfluidic devices for kinetic studies about MACs. Different microfabrication technologies will be combined to produce devices allowing the handling of small volumes of solution containing enzymes and isotopically enriched substrates and introduction into de mass spectrometer through an electrospray ionization source.

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO LAGO, CLAUDIMIR LUCIO; RAJH VIDAL, DENIS TADEU; MENDONCA FRANCISCO, KELLITON JOSE; DOS SANTOS, VAGNER BEZERRA. A simple approach to compensate the suction caused by the electrospray ionization source in capillary electrophoresis-mass spectrometry systems. ELECTROPHORESIS, v. 35, n. 16, SI, p. 2412-2416, AUG 2014. (11/02156-2, 13/14993-1, 12/06642-1)

DOS SANTOS, VAGNER BEZERRA; DANIEL, DANIELA; SINGH, MELINA; DO LAGO, CLAUDIMIR LUCIO. Amphetamine and derivatives in natural weight loss pills and dietary supplements by capillary electrophoresis-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1038, p. 19-25, DEC 1 2016. (13/14993-1, 12/06642-1)

DOS SANTOS, VAGNER B.; VIDAL, DENIS T. R.; FRANCISCO, KELLITON J. M.; DUCATI, LUCAS C.; DO LAGO, CLAUDIMIR L.. Formation of isomers of anionic hemiesters of sugars and carbonic acid in aqueous medium. Carbohydrate Research, v. 428, p. 18-22, JUN 16 2016. (11/02156-2, 13/14993-1, 12/06642-1)

DE OLIVEIRA, DENILSON MENDES; SUAREZ, WILLIAN TOITO; ALVARENGA JUNIOR, BENEDITO ROBERTO; GABRIEL, WESLEY LIRA; DOS SANTOS, VAGNER BEZERRA. Nitroprusside as a Novel Reagent for Flow Injection Spectrophotometric Determination of Captopril. Analytical Letters, v. 49, n. 2, p. 200-207, JAN 22 2016. (13/14993-1)

PESSOA-NETO, OSMUNDO DANTAS; SILVA, TIAGO ALMEIDA; DOS SANTOS, VAGNER BEZERRA; FATIBELLO-FILHO, ORLANDO. A Compact Microcontrolled Microfluidic System for Photometric Determination of Phosphate in Natural Water Samples. AUSTRALIAN JOURNAL OF CHEMISTRY, v. 68, n. 7, p. 1108-1114, 2015. (13/14993-1)

MONTES, RODRIGO H. O.; LIMA, ANA P.; DOS SANTOS, VAGNER B.; VIDAL, DENIS T. R.; DO LAGO, CLAUDIMIR L.; RICHTER, EDUARDO M.; MUNOZ, RODRIGO A. A.. Carbon-nanotube amperometric sensor for selective determination of 4-chloroaniline in commercial chlorhexidine solutions. SENSORS AND ACTUATORS B-CHEMICAL, v. 231, p. 38-44, AUG 2016. (11/02156-2, 13/14993-1, 12/06642-1)

DANIEL, DANIELA; LOPES, FERNANDO SILVA; DOS SANTOS, VAGNER BEZERRA; DO LAGO, CLAUDIMIR LUCIO. Detection of coffee adulteration with soybean and corn by capillary electrophoresis-tandem mass spectrometry. Food Chemistry, v. 243, p. 305-310, MAR 15 2018. (13/14993-1, 12/06642-1)

DANIEL, DANIELA; DOS SANTOS, VAGNER BEZERRA; RAJH VIDAL, DENIS TADEU; DO LAGO, CLAUDIMIR LUCIO. Determination of biogenic amines in beer and wine by capillary electrophoresis-tandem mass spectrometry. Journal of Chromatography A, v. 1416, p. 121-128, OCT 16 2015. (11/02156-2, 13/14993-1, 12/06642-1)

DOS SANTOS, VAGNER BEZERRA; FAVA, ELSON LUIZ; PESSOA-NETO, OSMUNDO DANTAS; BIANCHI, SILMARA ROSSANA; FARIA, RONALDO CENSI; FATIBELLO-FILHO, ORLANDO. A versatile and robust electrochemical flow cell with a boron-doped diamond electrode for simultaneous determination of Zn2+ and Pb2+ ions in water samples. ANALYTICAL METHODS, v. 6, n. 21, p. 8526-8534, NOV 7 2014. (10/11690-0, 13/14993-1)

DO LAGO, CLAUDIMIR LUCIO; MENDONA FRANCISCO, KELLITON JOSE; DANIEL, DANIELA; RAJH VIDAL, DENIS TADEU; DOS SANTOS, VAGNER BEZERRA. A capillary electrophoresis/tandem mass spectrometry approach for the determination of monoalkyl carbonates. RSC ADVANCES, v. 4, n. 38, p. 19674-19679, 2014. (11/02156-2, 13/14993-1, 12/06642-1)

DANIEL, DANIELA; DOS SANTOS, VAGNER BEZERRA; RAJH VIDAL, DENIS TADEU; DO LAGO, CLAUDIMIR LUCIO. Determination of halosulfuron-methyl herbicide in sugarcane juice and tomato by capillary electrophoresis-tandem mass spectrometry. Food Chemistry, v. 175, p. 82-84, MAY 15 2015. (11/02156-2, 13/14993-1, 12/06642-1)

DOS SANTOS, VAGNER BEZERRA; FAVA, ELSON LUIZ; DE MIRANDA CURI, NEWTON SA; FARIA, RONALDO CENSI; GUERREIRO, THIAGO BRITO; FATIBELLO-FILHO, ORLANDO. An electrochemical analyzer for in situ flow determination of Pb(II) and Cd(II) in lake water with on-line data transmission and a global positioning system. ANALYTICAL METHODS, v. 7, n. 7, p. 3105-3112, 2015. (10/11690-0, 13/14993-1)

DOS SANTOS, VAGNER B.; FAVA, ELSON L.; DE MIRANDA CURI, NEWTON S.; FARIA, RONALDO C.; FATIBELLO-FILHO, ORLANDO. A thermostated electrochemical flow cell with a coupled bismuth film electrode for square-wave anodic stripping voltammetric determination of cadmium(II) and lead(II) in natural, wastewater and tap water samples. Talanta, v. 126, p. 82-90, AUG 1 2014. (10/11690-0, 13/14993-1)

DO LAGO, CLAUDIMIR LUCIO; RAJH VIDAL, DENIS TADEU; MENDONCA FRANCISCO, KELLITON JOSE; DOS SANTOS, VAGNER BEZERRA. A simple approach to compensate the suction caused by the electrospray ionization source in capillary electrophoresis-mass spectrometry systems. ELECTROPHORESIS, v. 35, n. 16, p. 5-pg., 2014-08-01. (13/14993-1, 12/06642-1, 11/02156-2)