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Study of the application of B-glucosidase from Aspergillus niger LBA 02 immobilized on PVA-Lentikats® lenses and Sol-Gel in the biotransformation of soy isoflavones and evaluation of biological effects of isoflavones on models of obesity and inflammation

Grant number: 13/13212-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2015
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Hélia Harumi Sato
Grantee:Joelise de Alencar Figueira Angelotti
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Obesity is a chronic disease that affects millions of people in different age groups and socioeconomic groups worldwide. Since the cause is related to multiple factors among then imbalance between physical activity and food intake, endocrine and genetic factors, metabolic disorders, and may be associated or not. The disease is characterized by excessive accumulation of fat in various anatomical sites being called whole organ or tissue. In recent years find out that, contrary to what was thought, the adipose tissue has not only heat isolation function, protection against shock and energy reserves. Researchs have shown that adipose tissue plays an important endocrine and is responsible for the secretion by adipocytes of various substances such as hormones, cytokines and acute phase proteins relevant to the metabolism. The cytokines and acute phase proteins are related to inflammatory processes and are consistently found in high levels in obese individuals. Table of obesity is characterized by a chronic inflammatory process and of low intensity, which seems to act as a promoter of chronic non-infectious diseases. Countless studies have linked soy isoflavones to biological effects of inhibition of adipogenesis by acting on nuclear factors such as PPAR directly linked to regulatory pathways of adipogenesis. Soy isoflavones also act in the regulation of inflammatory processes associated to that tissue. Studies have shown that these aglycones are bioactive molecules and have beneficial effects on human health. The B-glucosidase is used commercially for the hydrolysis of isoflavone glycosides of soybean isoflavone aglycones in daidzein, genistein and glycitein. This project aims to evaluate the potential of bioactive extracts of soy isoflavones biotransformed obtained by catalysis of ²-glucosidase from Aspergillus niger LBA 02 immobilized (on lenses PVA - Lentikats ® and Sol-Gel), and its ability to regulate adipogenesis and inflammation associated with hypertrophy of adipose tissue, through in vitro models.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANGELOTTI, JOELISE A. F.; DIAS, FERNANDA F. G.; SATO, HELIA H.; FERNANDES, PEDRO; NAKAJIMA, VANIA M.; MACEDO, JULIANA. Improvement of Aglycone Content in Soy Isoflavones Extract by Free and Immobilized Beta-Glucosidase and their Effects in Lipid Accumulation. Applied Biochemistry and Biotechnology, v. 192, n. 3, . (13/13212-6)

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