Study of the expression of Vitamin D receptor in peritoneal and alveolar macrophages in healthy and diabetic mice

• Grant number: 13/20904-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2013
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Joilson de Oliveira Martins
• Grantee: Isis Fieri
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 10/02272-0 - Effect of insulin on lung inflammation in animal with sepsis, innate immunit,activation of insulin gene (BGK) and insulin receptors (IR)-A and IR-B, AP.JP

Abstract

Vitamin D is a steroid hormone synthesized in the skin, which is involved in many physiological processes (homeostasis of phosphorus and calcium, modulation of the immune system) and pathological (autoimmune diseases such as type 1 diabetes mellitus). This disease is characterized by destruction of beta cells through the action of pancreatic B lymphocytes, macrophages, T cells, CD4 + and CD8 + T cells that culminates in slow, progressive loss of insulin secretion. Studies have been demonstrated that vitamin D stimulates phagocytosis of the bacteria by macrophages as well as production of interleukin (IL)-1 and prostaglandin (PG)-E2. The aim of this work is to study the relationship between vitamin D supplementation, the expression of the vitamin D receptor (VDR - Western blotting) of peritoneal lavage macrophages (LP) and bronchoalveolar lavage (BAL) and the immune response in diabetic mice (alloxan 60 mg / kg, iv) and healthy. Thus, this project aims to expand the knowledge of the action of vitamin D in immunity, thereby improving the quality of life of diabetic patients, allowing better control of the disease, since this hormone replacement therapy is easy to perform and inexpensive. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELLA, LEONARDO M.; FIERI, ISIS; TESSARO, FERNANDO H. G.; NOLASCO, EDUARDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; AZEVEDO, CAROLINA B.; MARTINS, JOILSON O.. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BIOMED RESEARCH INTERNATIONAL, 2017. (13/20904-1, 12/23998-4, 14/05214-1, 10/02272-0)

BELLA, LEONARDO M.; FIERI, ISIS; TESSARO, FERNANDO H. G.; NOLASCO, EDUARDO L.; NUNES, FERNANDA P. B.; FERREIRA, SABRINA S.; AZEVEDO, CAROLINA B.; MARTINS, JOILSON O.. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BIOMED RESEARCH INTERNATIONAL, v. 2017, p. 10-pg., 2017-01-01. (13/20904-1, 12/23998-4, 10/02272-0, 14/05214-1)