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The role of CD8 T cells on Paraneoplastic cerebellar degeneration

Grant number: 13/22196-4
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Cristoforo Scavone
Grantee:Lidia Mitiko Yshii
Supervisor: Roland S. Liblau
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Institut National de la Santé et de la Recherche Médicale (Inserm), France  
Associated to the scholarship:11/10303-5 - TRAF6 and alfa-synuclein interaction and the subsequent modulation of signaling pathways, BP.PD


The inflammation on central nervous system (CNS) is an important factor in great number of neurological diseases, including autoimmune diseases to neurodegenerative diseases. The type of inflammation on CNS and the participation of cell types of immunological system can differ greatly depending on the disease. An essential role has been assigned to CD8 T lymphocytes in animal models of CNS inflammation and in several other neurological diseases like multiple sclerosis, Rasmussen encephalitis, viral encephalitis and paraneoplastic neurological degeneration. Furthermore, the involvement of CD8 T cells in autoimmune diseases that affect the CNS has received increased attention and complemented through the observation of resident cells on CNS, including neurons, that express the MHC (major histocompatibility complex) molecule class I in constitutive way. However, little is known from literature about the contribution of CD8 T cells in the inflammation and damage to CNS. The general objective of this project is to identify the traffic signaling involved on the recruitment of CD8 T cells to the CNS during the inflammatory disease. For this, we propose to investigate the in vitro migration of CD8 T cells in the CNS using organotypic cerebellar culture from double knock-in L7-HA mice that express the hemagglutinin protein (HA) of influenza virus only in Purkinje cells. Therefore, we purpose to identify the molecular pathways that allow the specific blocking of pathogenic CD8 T cells. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
YSHII, LIDIA; GEBAUER, CHRISTINA; BERNARD-VALNET, RAPHAEL; LIBLAU, ROLAND. Neurons and Tcells: Understanding this interaction for inflammatory neurological diseases. European Journal of Immunology, v. 45, n. 10, p. 2712-2720, . (13/22196-4)
YSHII, LIDIA M.; GEBAUER, CHRISTINA M.; PIGNOLET, BEATRICE; MAURE, EMILIE; QUERIAULT, CLEMENCE; PIERAU, MANDY; SAITO, HIROMITSU; SUZUKI, NOBORU; BRUNNER-WEINZIERL, MONIKA; BAUER, JAN; et al. CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN, v. 139, n. 11, p. 2923-2934, . (13/22196-4)
YSHII, LIDIA M.; MANFIOLLI, ADRIANA O.; DENADAI-SOUZA, ALEXANDRE; KINOSHITA, PAULA F.; GOMES, MARCELO D.; SCAVONE, CRISTOFORO. Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway. IBRO REPORTS, v. 9, p. 218-223, . (12/07784-4, 11/10303-5, 14/24951-7, 09/12375-3, 18/01308-2, 16/07427-8, 19/10044-1, 18/14289-6, 13/22196-4)

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