Development of analytical and confirmatory methods for multi-class residues of veterinary drugs determination in milk and beef meat using LC-MS/MS

• Grant number: 14/06909-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2014
• Effective date (End): January 31, 2015
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Jonas Augusto Rizzato Paschoal
• Grantee: Isabela Dias Rabelo Pimenta
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 12/18334-0 - Veterinary drug residues in food: multiclass analytical methods employing LC-MS/MS, exposition data and residual depletion study, AP.JP

Abstract

The veterinary pharmaceutical industry market in the world and even in Brazil, has shown significant growth over the last few years, highlighting the importance of using these substances in different animal production systems and advising on the need for inspection of products intended human consumption with regard to the issue of food security. Consistently, researchers have been working to improve the analytical methods in order to obtain reliable results even in trace concentrations of these substances (µg/kg). A major trend in recent analytical methods published in scientific literature search reveals the possibility of determining simultaneously the maximum number of compounds of veterinary drugs as possible from different therapeutic classes (antimicrobial, antiparasitic, etc.) in different food matrices in the same analysis. However, unlike what is already a reality for methods aimed at determination of pesticide residues, there are few multiresidue methods for veterinary drugs from different classes, able to meet the criteria needed for a wide range of different compounds. Brazil has national programs to monitoring of drugs (and possible metabolites) in many different food products of animal origin, but still lacking the availability of analytical methods like multiclass. Against this background, this project is proposed in order to contribute to the development and validation of analytical methods multiresidues, which can be applied for determining the largest number of veterinary drugs as possible in different classes (multiclass) and with the versatility to be used in analyzes of different food matrices, with the aim of contributing to national programs for monitoring these substances in foodstuffs of animal origin.