Additives, aromatic amines, nitrosamines and metals in baby bottles: analytical methodologies and study of migration

• Grant number: 14/14248-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: February 01, 2015
• End date: September 30, 2017
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Helena Teixeira Godoy
• Grantee: Wellington da Silva Oliveira
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 16/01099-9 - Incidence of NIAS in baby bottles: analytical methodologies and migration studies, BE.EP.DR

Abstract

Plastics are not inert and can interact with food products. Thus, the plastic materials used in manufacturing of baby bottles can interact with food and plastic components can migrate into the product, exposing children to monomers, additives, and other substances. Over 50% of the population uses baby bottles for feeding children between 0 and 12 months, however, there is a lack of data on the migration of substances from baby bottles manufactured from polypropylene and Tritan®, making it necessary to evaluate whether these materials are indeed safe for this purpose. Therefore, the aim of this study is to evaluate in baby bottles, by gas and liquid chromatography coupled to mass spectrometry, and spectroscopy (GC-MS, LC-MS and ICP-OES), the migration of phthalates, antioxidants, aromatic amines, N-nitrosamines and metals. Initially, will be the identification of the material of the baby bottle by Fourier transform infrared spectroscopy (FT-IR), since it is not always indicated on the label. Then, the baby bottles will be submitted to assays total migration and characterization, in which parameters such as height, weight, volume capacity, thickness and diameter are evaluated using ASTM methods. Later, after validation of the GC-MS methods for phthalates and nitrosamines, the LC-MS to aromatic amines and antioxidants, and ICP-OES for metals (Cd, Pb, Hg and Ar) testing of specific migration will be made using ethanol 50%, acetic acid 3% and synthetic saliva as simulant. How baby bottles are repeated use materials, testing should be done three times on the same specimen as recommended by Agência Nacional de Vigilância Sanitária (ANVISA). With the information achieved will be possible support the regulatory agencies regarding approval of use of materials, approval of new additives, as well as for managing the risk to consumer health (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEVES, DANIELA ANDRADE; OLIVEIRA, WELLINGTON DA SILVA; PETRARCA, MATEUS HENRIQUE; RODRIGUES, MARIA ISABEL; GODOY, HELENA TEIXEIRA. A multivariate approach to overcome chlorophyll interferences in the determination of polycyclic aromatic hydrocarbons in jambu (Acmella olerarea (L.) RK Jansen). Journal of Food Composition and Analysis, v. 104, DEC 2021. (14/14248-7)

OLIVEIRA, WELLINGTON DA SILVA; LIMA DE SOUZA, THAIS CRISTINA; PADULA, MARISA; GODOY, HELENA TEIXEIRA. Development of an Extraction Method Using Mixture Design for the Evaluation of Migration of Non-target Compounds and Dibutyl Phthalate from Baby Bottles. FOOD ANALYTICAL METHODS, v. 10, n. 7, p. 2619-2628, JUL 2017. (14/14248-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

OLIVEIRA, Wellington da Silva. Aditivos, aminas aromáticas, metais e nitrosaminas em mamadeiras: metodologias analíticas e estudos de migração. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia de Alimentos Campinas, SP.