Diet classic and modified ketogenic: evaluation of the therapeutic potential and impact on the oxidative, lipidomic profile, inflammatory and lipoproteins size in children and adolescents with refractory epilepsy

• Grant number: 14/26094-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2015
• End date: February 05, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Nágila Raquel Teixeira Damasceno
• Grantee: Patricia Azevedo de Lima
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The ketogenic diet is a non-pharmacological treatment prescribed especially for children and indicated in most specialized centers for patients with refractory epilepsy. The composition of the ketogenic diet is based on high-fat, low-carbohydrate, moderate protein content, and the production of ketone bodies the probable mechanism involved in the control of epileptic seizures. The relationship between the treatment of the ketogenic diet and changes in oxidative characteristics, physical and lipid are not well established. Some studies show a significant increase in total cholesterol and triglycerides in children being treated with ketogenic diet, but other studies have shown that changes in the lipid profile in the long term do not appear to be significant, and the influence of these changes on coronary heart disease are unknown. The studies performed in the last two decades have shown that in addition to alterations in lipid profile, oxidative modifications of lipoproteins is essential for the initiation and progression of atherosclerosis and physical properties of lipoproteins also appear to be involved in this process, suggesting that the particle size of lipoproteins, through the analysis of subfractions can provide more details of the cardiovascular risk. Thus, this project compares the effects of classical ketogenic diet with the ketogenic diet modified with lower content of saturated fatty acids and a higher content of monounsaturated and polyunsaturated, in the oxidative changes of LDL in lipidomic profile, concentration of antioxidants, in the production of inflammatory cytokines and the subfractions of LDL and HDL in children and adolescents with refractory epilepsy, the clinical effect on controlling epilepsy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, PATRICIA AZEVEDO; DE BRITO SAMPAIO, LETICIA PEREIRA; TEIXEIRA DAMASCENO, NAGILA RAQUEL. Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress. NUTRITIONAL NEUROSCIENCE, v. 18, n. 8, p. 337-344, NOV 2015. (12/03775-0, 14/26094-4)

DE LIMA, PATRICIA AZEVEDO; PRUDENCIO, MARIANA BALDINI; MURAKAMI, DANIELA KAWAMOTO; DE BRITO SAMPAIO, LETICIA PEREIRA; FIGUEIREDO NETO, ANTONIO MARTINS; TEIXEIRA DAMASCENO, NAGILA RAQUEL. Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy. NUTRITION, v. 33, p. 271-277, JAN 2017. (12/03775-0, 11/13616-4, 14/26094-4, 12/20789-5)

PRUDENCIO, MARIANA BALDINI; DE LIMA, PATRICIA AZEVEDO; MURAKAMI, DANIELA KAWAMOTO; SAMPAIO, LETICIA PEREIRA DE BRITO; DAMASCENO, NAGILA RAQUEL TEIXEIRA. Micronutrient supplementation needs more attention in patients with refractory epilepsy under ketogenic diet treatment. NUTRITION, v. 86, JUN 2021. (15/24928-8, 12/20789-5, 14/26094-4, 14/50983-3)