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In vivo analysis of the inflammatory response of patients with chronic obstructive pulmonary disease (COPD) in orange juice and orange juice with lycopene intake

Grant number: 15/16738-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Sergio Alberto Rupp de Paiva
Grantee:Bruna Paola Murino Rafacho
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a progressive disorder characterized by airflow limitation associated with chronic inflammatory response. It is one of the main causes of mortality in Brazil, representing an important public health problem. On the other hand, consumption of food sources of bioactive compounds (CBAs) as flavonoids, are associated with lower risk of chronic diseases. The orange juice has great consumption in Brazil and in the world and it is the main source of bioactive compounds for the Brazilian population. Several studies have reported that bioactive compounds have antioxidant and anti-inflammatory activity. Previous studies have shown that consumption of compounds present in orange juice can reduce inflammation. However, the molecular mechanisms responsible for this beneficial effect have not been clarified. This work aims to study the inflammatory response and changes in protein expression and microRNA (miRNA) by the consumption of two types of orange juice in patients with COPD. Individuals consume orange juice, orange juice with lycopene or isocaloric control (water with maltodextrin and vitamin C), followed by blood collections at 0, 1, 3 and 5 hours. The inflammatory response and the expression of miRNAs will be evaluated in the blood. Accordingly, from the present study, changes in inflammatory and epigenetic markers resulting from the intake of two types of orange juice in COPD patients can be identified, as well some molecular mechanisms involved in this signaling.