Chronic Obstructive Pulmonary Disease (COPD) is a progressive disorder characterized by airflow limitation associated with chronic inflammatory response. It is one of the main causes of mortality in Brazil, representing an important public health problem. On the other hand, consumption of food sources of bioactive compounds (CBAs) as flavonoids, are associated with lower risk of chronic diseases. The orange juice has great consumption in Brazil and in the world and it is the main source of bioactive compounds for the Brazilian population. Several studies have reported that bioactive compounds have antioxidant and anti-inflammatory activity. Previous studies have shown that consumption of compounds present in orange juice can reduce inflammation. However, the molecular mechanisms responsible for this beneficial effect have not been clarified. This work aims to study the inflammatory response and changes in protein expression and microRNA (miRNA) by the consumption of two types of orange juice in patients with COPD. Individuals consume orange juice, orange juice with lycopene or isocaloric control (water with maltodextrin and vitamin C), followed by blood collections at 0, 1, 3 and 5 hours. The inflammatory response and the expression of miRNAs will be evaluated in the blood. Accordingly, from the present study, changes in inflammatory and epigenetic markers resulting from the intake of two types of orange juice in COPD patients can be identified, as well some molecular mechanisms involved in this signaling.
News published in Agência FAPESP Newsletter about the scholarship: